My interests involve the role of G protein-coupled receptors (GPCR) in development. We have cloned the gene that codes for the largest GPCR known thus far, VLGR1. Presently, we are characterizing the function of VLGR1 to determine its role in development of the mammalian nervous system. Additionally, I am interested in the role steroids in cardiac function. We are currently developing a novel animal model to examine this role.


Graduate School Hermleigh High School (1974), None
Undergraduate Angelo State University (1979), Biology
Graduate School Angelo State University (1982), Biology
Graduate School Texas Tech University (1991), Biochemistry

Research Interest

  • Role of G protein-coupled receptors (GPCR) in development
  • Role of steroids in cardiac function


Featured Publications LegendFeatured Publications

Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice
McMillan DR. Christians E. Forster M. Xiao X. Connell P. Plumier JC. Zuo X. Richardson J. Morgan S. Benjamin IJ Molecular & Cellular Biology November 2002 22(22) 8005-14
Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system
McMillan DR. Kayes-Wandover KM. Richardson JA. White PC. Journal of Biological Chemistry January 2002 277(1) 785-92
Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain
Nikkila H. McMillan DR. Nunez BS. Pascoe L. Curnow KM. White PC. Molecular Endocrinology September 2000 14(9) 1351-64