Dr. Luis Franco is originally from Brazil and received his PhD in Immunology from the University of São Paulo, Ribeirão Preto, Brazil. Dr. Franco’s research is focused on the study of host-pathogen interactions, with emphasis on innate immunity. Currently, Dr. Franco studies how autophagy protects against infection by M. tuberculosis and works on the development of new therapeutics for tuberculosis treatment. Out of the lab, Dr. Franco’s interests include music, sports and outdoor activities.


University of Sao Paulo (2002), Biological Sciences
Graduate School
University of Sao Paulo (2005), Immunology
Graduate School
University of Sao Paulo (2009), Immunology

Research Interest

  • Autophagy
  • Innate Immunity
  • Tuberculosis


Featured Publications LegendFeatured Publications

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.
Collins AC, Cai H, Li T, Franco LH, Li XD, Nair VR, Scharn CR, Stamm CE, Levine B, Chen ZJ, Shiloh MU Cell Host Microbe 2015 Jun 17 6 820-8
Monocyte Migration Driven by Galectin-3 Occurs through Distinct Mechanisms Involving Selective Interactions with the Extracellular Matrix.
Danella Polli C, Alves Toledo K, Franco LH, Sammartino Mariano V, de Oliveira LL, Soares Bernardes E, Roque-Barreira MC, Pereira-da-Silva G ISRN Inflamm 2013 2013 259256
Protection conferred by heterologous vaccination against tuberculosis is dependent on the ratio of CD4(+) /CD4(+)  Foxp3(+) cells.
Fedatto PF, Sérgio CA, Paula MO, Gembre AF, Franco LH, Wowk PF, Ramos SG, Horn C, Marchal G, Turato WM, Silva CL, da Fonseca DM, Bonato VL Immunology 2012 Nov 137 3 239-48
Innate immune activation and subversion of Mammalian functions by leishmania lipophosphoglycan.
Franco LH, Beverley SM, Zamboni DS J Parasitol Res 2012 2012 165126
Leukotrienes are not essential for the efficacy of a heterologous vaccine against Mycobacterium tuberculosis infection.
Franco LH, Paula MO, Wowk PF, Fonseca DM, Sérgio CA, Fedatto PF, Gembre AF, Ramos SG, Silva CL, Medeiros AI, Faccioli LH, Bonato VL Braz. J. Med. Biol. Res. 2010 Jul 43 7 645-50
Experimental tuberculosis: designing a better model to test vaccines against tuberculosis.
Morais Fonseca D, Rosada RS, e Paula MO, Wowk PF, Franco LH, Soares EG, Silva CL, Deperon Bonato VL Tuberculosis (Edinb) 2010 Mar 90 2 135-42
A DNA vaccine against tuberculosis based on the 65 kDa heat-shock protein differentially activates human macrophages and dendritic cells.
Franco LH, Wowk PF, Silva CL, Trombone AP, Coelho-Castelo AA, Oliver C, Jamur MC, Moretto EL, Bonato VL Genet Vaccines Ther 2008 6 3