Dr. David J. Mangelsdorf received his BS in Biology and Chemistry from Northern Arizona University in Flagstaff (1981) and his PhD in Biochemistry from the University of Arizona in Tucson (1987). He did his postdoctoral studies at The Salk Institute for Biological Studies. Since 1993 he has been at UT Southwestern, where he currently is Professor and Chair of the Department of Pharmacology, and an Investigator of the Howard Hughes Medical Institute. He holds the Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology, in Honor of Harold B. Crasilneck, PhD and the Alfred G. Gilman Distinguished Chair in Pharmacology, and he is a member of the National Academy of Sciences.
Dr. Mangelsdorf runs a joint laboratory with Dr. Steven Kliewer, and together their research team is focused on nuclear receptor regulation of metabolism. Their early work identifying the ligands and physiologic functions of a number of orphan nuclear receptors led them to discover two new signaling pathways mediated by the endocrine factors FGF19 and FGF21, which govern nutrient metabolism during feeding and fasting. Together, this work has uncovered potential therapeutic targets for diseases such as cholestasis, type 2 diabetes, and obesity. The Mangelsdorf/Kliewer lab also discovered the existence of a nuclear receptor pathway in parasitic nematodes, and has shown that pharmacophores that target this pathway may represent a new class of anthelmintic agents.
- Northern Arizona University , Aquatic Biology
- Graduate School
- University of Arizona (1987)
- Molecular biology of orphan nuclear receptors
- Nutrient metabolsim and regulation of energy expenditure
- The role of nuclear receptors in physiology and disease
- FGF21 Regulates Sweet and Alcohol Preference.
- Talukdar S, Owen BM, Song P, Hernandez G, Zhang Y, Zhou Y, Scott WT, Paratala B, Turner T, Smith A, Bernardo B, Müller CP, Tang H, Mangelsdorf DJ, Goodwin B, Kliewer SA Cell Metab. 2015 Dec
- The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes.
- Wang Z, Stoltzfus J, You YJ, Ranjit N, Tang H, Xie Y, Lok JB, Mangelsdorf DJ, Kliewer SA PLoS Genet. 2015 Mar 11 3 e1005027
- Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21.
- Owen BM, Mangelsdorf DJ, Kliewer SA Trends Endocrinol. Metab. 2015 Jan 26 1 22-29
- Nuclear Receptors, RXR, and the Big Bang.
- Evans RM, Mangelsdorf DJ Cell 2014 Mar 157 1 255-266
- FGF21 regulates metabolism and circadian behavior by acting on the nervous system.
- Bookout AL, de Groot MH, Owen BM, Lee S, Gautron L, Lawrence HL, Ding X, Elmquist JK, Takahashi JS, Mangelsdorf DJ, Kliewer SA Nat. Med. 2013 Aug
- FGF21 contributes to neuroendocrine control of female reproduction.
- Owen BM, Bookout AL, Ding X, Lin VY, Atkin SD, Gautron L, Kliewer SA, Mangelsdorf DJ Nat. Med. 2013 Aug
- FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.
- Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ Science 2011 Mar 331 6024 1621-4
- Endocrine Regulation of the Fasting Response by PPARalpha-mediated Induction of Fibroblast Growth Factor 21.
- Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., Elmquist, J.K., Gerard, R.D., Burgess, S.C., Hammer, R.E., Mangelsdorf, D.J., Kliewer, S.A. Cell Metabolism 2007 5 415-425
- Identification of a nuclear receptor for bile acids.
- Makishima, M., Okamoto, A.Y., Repa, J.J., Tu, H., Learned, R.M., Luk, A., Hull, M.V., Lustig, K.D., Mangelsdorf, D.J., and Shan, B. Science 1999 284 362-365
- Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor, LXRα.
- Peet, D.J., Turley, S.D., Ma, W., Janowski, B.A., Lobaccaro, J.A., Hammer, R.E., and Mangelsdorf, D.J. Cell May 1998 93 693-704
Honors & Awards
- Honorary Doctor of Humane Letters, Northern Arizona University
- The Rolf Luft Award
Karolinska Institutet, for outstanding contributions in endocrinology and diabetes research. (2012)
- Docteur Honoris Causa, Universite Blaise Pascal
- National Academy of Sciences
- Edith and Peter O’Donnell Award in Medicine
The Academy of Medicine, Engineering and Science of Texas (2007)
- Transatlantic Medal
The European Society of Endocrinology (2006)
- Gerald D. Aurbach Award
The Endocrine Society (2004)
- Heinrich Wieland Prize
Boehringer Ingelheim (2003)
- Adolf Windaus Prize
Work in the field of bile acid research (2000)
- John J. Abel Award in Pharmacology
American Society for Pharmacology and Experimental Therapeutics (1997)
- National Academy of Sciences (2008)
- The Academy of Medicine, Engineering and Science of Texas (2008)
- American Association for Cancer Research
- American Society for Pharmacology and Experimental Therapeutics
- The Endocrine Society