Dr. Ge obtained his B.S. in Biochemistry (2000) at East China Normal University and his Ph. D. in Neurobiology (2005) at the Institute of Neuroscience, Chinese Academy of Sciences. His Ph. D. research was on neuron-glia signaling. Postdoctoral research conducted at the University of California, San Francisco was on glial cell generation. Dr. Ge joined the faculty as an Assistant Professor in Children’s Research Institute (CRI) at the UT Southwestern Medical Center in September 2013.
An adult human brain accounts for 2% of total body weight but consumes approximately 20% of the body’s energy. Interactions between the brain vasculature (i.e., blood vessels), glial cells and neurons are critical for brain metabolism. The goal of Ge Lab is to understand the mechanisms underlying the interactions between the brain vasculature and the nervous system. Combining electrophysiology and in vivo imaging with genetic methods, Ge Lab studies how a brain builds the gliovascular and neurovascular network during development or after brain damages, e.g., ischemic stroke. Ultimately, this focus might lead to the development of novel therapeutic targets for treating stroke, which affects about 700,000 Americans each year. In addition, Ge Lab is interested in developing new tools in the study of brain development, brain vasculature, and neurovascular/gliovascular interaction in live animals. See more at http://cri.utsw.edu. or contact firstname.lastname@example.org
- East China Normal University (2000), Biochemistry
- Graduate School
- Chinese Academy of Sciences (2005), Neuroscience
- Development of new tools
- Glial cells
- The interactions between the brain vasculature (blood vessels) and the nervous system (neurons/glia)
- Control of cerebral ischemia with magnetic nanoparticles
- Jia JM, Chowdary PD, Gao X, Ci B, Li W, Mulgaonkar A, Plautz EJ, Hassan G, Kumar A, Stowe AM, Yang SH, Zhou W, Sun X, Cui B, Ge WP. Nat. Methods 2016 doi: 10.1038/nmeth.4105. [Epub ahead of print] Feb. 2017
- Local generation of glia is a major astrocyte source in postnatal cortex.
- Ge WP, Miyawaki A, Gage FH, Jan YN, Jan LY. Nature. 2012 484(7394) 376-80.
- Dividing glial cells maintain differentiated properties including complex morphology and functional synapses.
- Ge WP, Zhou W, Luo Q, Jan LY, Jan YN. Proc Natl Acad Sci U S A. 2009 106(1) 328-33
- Long-term potentiation of neuron-glia synapses mediated by Ca2+-permeable AMPA receptors.
- Ge WP*, Yang XJ*, Zhang Z, Wang HK, Shen W, Deng QD, Duan S.(co-first author) Science 2006 312(5779) 1533-7
- Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.
- Ultanir SK, Hertz NT, Li G, Ge WP, Burlingame AL, Pleasure SJ, Shokat KM, Jan LY, Jan YN. Neuron 2012 73(6) 1127-42
- Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein.
- Lee HY, Ge WP, Huang W, He Y, Wang GX, Rowson-Baldwin A, Smith SJ, Jan YN, Jan LY. Neuron. 2011 72(4)
- G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation.
- Chung HJ*, Ge WP*, Qian X, Wiser O, Jan YN, Jan LY. (co-first author) Proc Natl Acad Sci U S A. 2009 106(2) 635-40
- Persistent enhancement of neuron-glia signaling mediated by increased extracellular K+ accompanying long-term synaptic potentiation.
- Ge WP, Duan S. J Neurophysiol. 2007 97(3) 2564-9
- Identification and two-photon imaging of oligodendrocyte in CA1 region of hippocampal slices.
- Zhou W, Ge WP, Zeng S, Duan S, Luo Q. Biochem Biophys Res Commun. 2007 352(3) 598-602
- A toolbox for light control of Drosophila behaviors through Channelrhodopsin 2-mediated photoactivation of targeted neurons.
- Zhang W, Ge W, Wang Z. Eur J Neurosci. 2007 26(9) 2405-16
Honors & Awards
- NINDS Pathway to Independence Award (K99/R00)
- 100 Excellent Ph.D. theses of China
- China's Top 10 Advances in Basic Research in 2006
- Human Frontier Science Program Long-term Fellowship Award
- Children's Medical Center Research Institute (CRI) (2013)
- Department of Neuroscience (2013)
- Department of Pediatrics (2013)