The focus of my current research is to understand mechanisms of cellular signaling at the level of the primary cilia, and its relevance to human health and disease. My first experience in hands-on research was as a medical student, when I studied the tyrosine kinase signaling pathways important in human platelet activation. During my graduate years, I utilized the model organism C. elegans to study the mechanisms that determine the distinctive ciliary morphology of their sensory neurons. We discovered that the membrane architecture of the olfactory sensory cilia is patterned by coincidental signaling inputs, suggesting that cilia are not just static antennae, but organelles whose structures are remodeled by their signaling activities. Incidentally, this was a very exciting period in ciliary research, because the near-complete parts list of the primary cilia was being discovered by multiple groups. Therefore, in my postdoctoral years, I could not resist the opportunity to use high-confidence proteomic approaches to identify novel effectors of conserved ciliary complexes (such as the IFT-A complex) in compartmentalizing signaling modules. In particular, our identification of the potentially broad role of the IFT-A effector, TULP3, in regulating ciliary GPCR trafficking provides intriguing insights into molecular mechanisms regulating ciliary function in diverse processes, such as in neural tube development and neuronal control of obesity. My current and future research aims at utilizing a variety of biochemical, cell biological and reverse genetic approaches to understanding signaling mediated by cilia, and dissecting their role during cell cycle control and carcinogenesis.
|Medical School||Banaras Hindu University (2002), Biochemistry|
|Graduate School||Brandeis University (2008), Biology|
- Ciliary signaling pathways
- Functional proteomics in ciliary diseases
- Primary cilia in normal development and cancer
- G-protein-coupled receptors, Hedgehog signaling and primary cilia.
- Mukhopadhyay S, Rohatgi R Semin. Cell Dev. Biol. 2014 May
- The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling.
- Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK Cell 2013 Jan 152 1-2 210-223
- Cilia, tubby mice, and obesity.
- Mukhopadhyay S, Jackson PK Cilia 2013 Jan 2 1 1
- The tubby family proteins.
- Mukhopadhyay S, Jackson PK Genome Biol. 2011 12 6 225
- TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.
- Mukhopadhyay S, Wen X, Chih B, Nelson CD, Lane WS, Scales SJ, Jackson PK Genes Dev. 2010 Oct 24 19 2180-93
- G-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning.
- Hwang SH, Mukhopadhyay S Birth Defects Res. Part A Clin. Mol. Teratol. 2014 Jun
- Primary cilium and sonic hedgehog signaling during neural tube patterning Role of GPCRs and Second Messengers.
- Pal K, Mukhopadhyay S Dev Neurobiol 2014 May
- An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.
- Wright KJ, Baye LM, Olivier-Mason A, Mukhopadhyay S, Sang L, Kwong M, Wang W, Pretorius PR, Sheffield VC, Sengupta P, Slusarski DC, Jackson PK Genes Dev. 2011 Nov 25 22 2347-60
- Cis-regulatory mechanisms of gene expression in an olfactory neuron type in Caenorhabditis elegans.
- Nokes EB, Van Der Linden AM, Winslow C, Mukhopadhyay S, Ma K, Sengupta P Dev. Dyn. 2009 Dec 238 12 3080-92
- Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans.
- Mukhopadhyay S, Lu Y, Shaham S, Sengupta P Dev. Cell 2008 May 14 5 762-74
Honors & Awards
- W.W. Caruth, Jr. Scholar in Biomedical Research
Endowed scholar, UT Southwestern (2013)
- CPRIT Scholar in Cancer Research.
- Member, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center. (2013)
- American Society for Cell Biology. (2005)