The focus of my current research is to understand mechanisms of cellular signaling at the level of the primary cilia, and its relevance to human health and disease. My first experience in hands-on research was as a medical student, when I studied the tyrosine kinase signaling pathways important in human platelet activation. During my graduate years, I utilized the model organism C. elegans to study the mechanisms that determine the distinctive ciliary morphology of their sensory neurons. We discovered that the membrane architecture of the olfactory sensory cilia is patterned by coincidental signaling inputs, suggesting that cilia are not just static antennae, but organelles whose structures are remodeled by their signaling activities. Incidentally, this was a very exciting period in ciliary research, because the near-complete parts list of the primary cilia was being discovered by multiple groups. Therefore, in my postdoctoral years, I could not resist the opportunity to use high-confidence proteomic approaches to identify novel effectors of conserved ciliary complexes (such as the IFT-A complex) in compartmentalizing signaling modules. In particular, our identification of the potentially broad role of the IFT-A effector, TULP3, in regulating ciliary GPCR trafficking provides intriguing insights into molecular mechanisms regulating ciliary function in diverse processes, such as in neural tube development and neuronal control of obesity. My current and future research aims at utilizing a variety of biochemical, cell biological and reverse genetic approaches to understanding signaling mediated by cilia, and dissecting their role during cell cycle control and carcinogenesis.
- (1998), Medicine
- Medical School
- Banaras Hindu University (2002), Medicine
- Graduate School
- Brandeis University (2008), Biology
- Ciliary signaling pathways
- Functional proteomics in ciliary diseases
- Primary cilia in normal development and cancer
- Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
- Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S J. Cell Biol. 2017 Feb
- Tubby proteins prove their adaptability.
- Short B J. Cell Biol. 2017 Feb
- Trafficking to the primary cilium membrane.
- Mukhopadhyay S, Badgandi HB, Hwang SH, Somatilaka B, Shimada IS, Pal K Mol. Biol. Cell 2017 Jan 28 2 233-239
- Smoothened determines ß-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.
- Pal K, Hwang SH, Somatilaka B, Badgandi H, Jackson PK, DeFea K, Mukhopadhyay S J. Cell Biol. 2016 Mar
- G-protein-coupled receptors, Hedgehog signaling and primary cilia.
- Mukhopadhyay S, Rohatgi R Semin. Cell Dev. Biol. 2014 May
- The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling.
- Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK Cell 2013 Jan 152 1-2 210-223
- Cilia, tubby mice, and obesity.
- Mukhopadhyay S, Jackson PK Cilia 2013 Jan 2 1 1
- The tubby family proteins.
- Mukhopadhyay S, Jackson PK Genome Biol. 2011 12 6 225
- TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.
- Mukhopadhyay S, Wen X, Chih B, Nelson CD, Lane WS, Scales SJ, Jackson PK Genes Dev. 2010 Oct 24 19 2180-93
- G-protein-coupled receptor signaling and neural tube closure defects.
- Shimada IS, Mukhopadhyay S Birth Defects Res. Part A Clin. Mol. Teratol. 2016 Oct
Honors & Awards
- Alexs Lemonade Stand Foundation A grant awardee
- W.W. Caruth, Jr. Scholar in Biomedical Research
Endowed scholar, UT Southwestern (2013)
- CPRIT Scholar in Cancer Research.
- Member, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center. (2013)
- American Society for Cell Biology. (2005)