Education

Undergraduate
University of Illinois Urbana (1969), Chemistry
Graduate School
Michigan State University (1974), Biochemistry

Research Interest

  • Cellular identity and cancer
  • Organogenesis
  • Transcriptional control of development

Publications

Featured Publications LegendFeatured Publications

Isolated pancreatic aplasia due to a hypomorphic PTF1A mutation.
Houghton JA, Swift GH, Shaw-Smith C, Flanagan SE, de Franco E, Caswell R, Hussain K, Mohamed S, Abdulrasoul M, Hattersley AT, MacDonald RJ, Ellard S Diabetes 2016 Jun
The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.
Krah NM, De La O JP, Swift GH, Hoang CQ, Willet SG, Chen Pan F, Cash GM, Bronner MP, Wright CV, MacDonald RJ, Murtaugh LC Elife 2015 Jul 4
Dominant and context-specific control of endodermal organ allocation by Ptf1a.
Willet SG, Hale MA, Grapin-Botton A, Magnuson MA, MacDonald RJ, Wright CV Development 2014 Nov 141 22 4385-94
Program specificity for Ptf1a in Pancreas versus Neural Tube Development correlates with distinct collaborating cofactors and chromatin accessibility.
Meredith DM, Borromeo MD, Deering TG, Casey B, Savage TK, Mayer PR, Hoang C, Tung KC, Kumar M, Shen C, Swift GH, Macdonald RJ, Johnson JE Mol. Cell. Biol. 2013 Jun
Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells.
Afelik S, Qu X, Hasrouni E, Bukys MA, Deering T, Nieuwoudt S, Rogers W, Macdonald RJ, Jensen J Development 2012 May 139 10 1744-53
Induced MIST1 Expression Promotes Remodeling Of Mouse Pancreatic Acinar Cells.
Direnzo D, Hess DA, Damsz B, Hallet JE, Marshall B, Goswami C, Liu Y, Deering T, Macdonald RJ, Konieczny SF Gastroenterology 2012 Apr
Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.
Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsässer HP, Magnuson MA, MacDonald RJ Gastroenterology 2010 Jul 139 1 270-80