University of Illinois Urbana (1969), Chemistry
Graduate School
Michigan State University (1974), Biochemistry

Research Interest

  • Evolution of developmental programs
  • Organogenesis
  • Transcriptional control of development


Featured Publications LegendFeatured Publications

Dominant and context-specific control of endodermal organ allocation by Ptf1a.
Willet SG, Hale MA, Grapin-Botton A, Magnuson MA, MacDonald RJ, Wright CV Development 2014 Nov 141 22 4385-94
The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell-formation and acinar differentiation during pancreatic organogenesis.
Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, Xue J, MacDonald RJ Development 2014 Jul
Program specificity for Ptf1a in Pancreas versus Neural Tube Development correlates with distinct collaborating cofactors and chromatin accessibility.
Meredith DM, Borromeo MD, Deering TG, Casey B, Savage TK, Mayer PR, Hoang C, Tung KC, Kumar M, Shen C, Swift GH, Macdonald RJ, Johnson JE Mol. Cell. Biol. 2013 Jun
Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells.
Afelik S, Qu X, Hasrouni E, Bukys MA, Deering T, Nieuwoudt S, Rogers W, Macdonald RJ, Jensen J Development 2012 May 139 10 1744-53
Induced MIST1 Expression Promotes Remodeling Of Mouse Pancreatic Acinar Cells.
Direnzo D, Hess DA, Damsz B, Hallet JE, Marshall B, Goswami C, Liu Y, Deering T, Macdonald RJ, Konieczny SF Gastroenterology 2012 Apr
LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.
Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, Kliewer SA, MacDonald RJ Genes Dev. 2011 Aug 25 16 1674-9
Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.
Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsässer HP, Magnuson MA, MacDonald RJ Gastroenterology 2010 Jul 139 1 270-80
PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.
Beres TM, Masui T, Swift GH, Shi L, Henke RM, MacDonald RJ Mol. Cell. Biol. 2006 Jan 26 1 117-30