Undergraduate University of Illinois Urbana Campus (1969), Chemistry
Graduate School Michigan State University (1974), Biochemistry

Research Interest

  • Evolution of developmental programs
  • Organogenesis
  • Transcriptional control of development


Featured Publications LegendFeatured Publications

Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells.
Afelik S, Qu X, Hasrouni E, Bukys MA, Deering T, Nieuwoudt S, Rogers W, Macdonald RJ, Jensen J Development 2012 May 139 10 1744-53
Induced MIST1 Expression Promotes Remodeling Of Mouse Pancreatic Acinar Cells.
Direnzo D, Hess DA, Damsz B, Hallet JE, Marshall B, Goswami C, Liu Y, Deering T, Macdonald RJ, Konieczny SF Gastroenterology 2012 Apr
LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.
Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, Kliewer SA, MacDonald RJ Genes Dev. 2011 Aug 25 16 1674-9
Notch-independent functions of CSL.
Johnson JE, Macdonald RJ Curr. Top. Dev. Biol. 2011 97 55-74
Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.
Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsässer HP, Magnuson MA, MacDonald RJ Gastroenterology 2010 Jul 139 1 270-80
Conditional control of the differentiation competence of pancreatic endocrine and ductal cells by Fgf10.
Kobberup S, Schmerr M, Dang ML, Nyeng P, Jensen JN, MacDonald RJ, Jensen J Mech. Dev. 2010 Apr 127 3-4 220-34
Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood.
Masui T, Swift GH, Hale MA, Meredith DM, Johnson JE, Macdonald RJ Mol. Cell. Biol. 2008 Sep 28 17 5458-68
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE Genes Dev. 2008 Jan 22 2 166-78
PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.
Beres TM, Masui T, Swift GH, Shi L, Henke RM, MacDonald RJ Mol. Cell. Biol. 2006 Jan 26 1 117-30
Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn.
Glasgow SM, Henke RM, Macdonald RJ, Wright CV, Johnson JE Development 2005 Dec 132 24 5461-9