Hasan Zaki, Ph.D., Assistant Professor of Pathology, studies gastrointestinal inflammation and cancer. His research interests include host-pathogen interaction, the role of pathogen sensors in intestinal inflammation and cancer, pathogenic mechanisms of inflammatory bowel disease and colorectal cancer, and identifying immune checkpoints of gastrointestinal disorders that could be targeted for therapeutic intervention and drug development.
Dr. Zaki earned his undergraduate and master's degrees in microbiology at the University of Dhaka, Bangladesh. He then joined the International Center for Diarrheal Disease Research, Bangladesh, where he studied immune responses against enteric pathogens. He did his doctoral research in the Department of Microbiology at Kumamoto University School of Medicine, Kumamoto, Japan, where he investigated the molecular mechanisms of host defense function of nitric oxide during gastrointestinal infection caused by Salmonella Typhimurium.
Dr. Zaki did postdoctoral research at Kumamoto University and later at St. Jude Children's Research Hospital in Memphis, Tenn. His postdoctoral studies demonstrated how NOD-like receptor (NLR) family members, particularly NLRP3 and NLRP12, suppress intestinal inflammation and cancer, and maintain intestinal homeostasis. His recent study shows that cytosolic DNA sensor AIM2 is a critical regulator of intestinal microbiota and inflamamtion.
- Graduate School
- Kumamoto University - Japan (2007), Microbiology
- Colorectal Cancer
- Host Pathogen Interaction
- Inflammatory Bowel Disease
- NOD-Like Receptors
- The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense
- Shuiqing Hu, Lan Peng, Youn-Tae Kwak, Erin McElvania Tekippe, Chandrashekhar Pasare, James S. Malter, Lora V. Hooper, Md. Hasan Zaki Cell Reports 2015 13 9 1922-1936
- Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection.
- Zaki MH, Man SM, Vogel P, Lamkanfi M, Kanneganti TD Proc. Natl. Acad. Sci. U.S.A. 2014 Jan 111 1 385-90
- The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.
- Zaki MH, Vogel P, Malireddi RK, Body-Malapel M, Anand PK, Bertin J, Green DR, Lamkanfi M, Kanneganti TD Cancer Cell 2011 Nov 20 5 649-60
- The Nlrp3 inflammasome: contributions to intestinal homeostasis.
- Zaki MH, Lamkanfi M, Kanneganti TD Trends Immunol. 2011 Apr 32 4 171-9
- Inflammasomes and Intestinal Tumorigenesis.
- Zaki MH, Lamkanfi M, Kanneganti TD Drug Discov Today Dis Mech 2011 8 3-4 e71-e78
- The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.
- Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD Immunity 2010 Mar 32 3 379-91
- Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.
- Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, Akaike T Nat. Chem. Biol. 2007 Nov 3 11 727-35
- The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells.
- Lukens JR, Gurung P, Shaw PJ, Barr MJ, Zaki MH, Brown SA, Vogel P, Chi H, Kanneganti TD. Immunity 2015
- Drak2 is not required for tumor surveillance and suppression.
- Edwards BA, Harris TL, Floersh H, Lukens JR, Zaki MH, Vogel P, Kanneganti TD, Bui JD, McGargill MA. 2015
- Role of inflammasomes in host defense against Citrobacter rodentium infection.
- Liu Z, Zaki MH, Vogel P, Gurung P, Finlay BB, Deng W, Lamkanfi M, Kanneganti TD J. Biol. Chem. 2012 May 287 20 16955-64
Honors & Awards
- Career Development Award, Crohn's and Colitis Foundation of America (2012)
- MEXT Scholarship (2002)
- Trainee Award, American Association for Immunologists (2011)
- Travel Award, Keystone Meeting (2012)
- American Association for Advancement of Schience (2012)
- American Association of Immunologists (2012)
- Chron's and Colitis Foundation of America (2012)