Featured Publications
Retinoblastoma and phosphate and tensin homolog tumor suppressors: impact on ductal carcinoma in situ progression.
Knudsen ES, Pajak TF, Qeenan M, McClendon AK, Armon BD, Schwartz GF, Witkiewicz AK J. Natl. Cancer Inst. 2012 Dec 104 23 1825-36
RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancer.
Witkiewicz AK, Ertel A, McFalls J, Valsecchi ME, Schwartz G, Knudsen ES Clin. Cancer Res. 2012 Sep 18 18 5110-22
RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control.
Bourgo RJ, Thangavel C, Ertel A, Bergseid J, McClendon AK, Wilkens L, Witkiewicz AK, Wang JY, Knudsen ES Mol. Cell 2011 Aug 43 4 663-72
Targeting the RB-pathway in cancer therapy.
Knudsen ES, Wang JY Clin. Cancer Res. 2010 Feb 16 4 1094-9
Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors.
Dean JL, McClendon AK, Hickey TE, Butler LM, Tilley WD, Witkiewicz AK, Knudsen ES Cell Cycle 2012 Jul 11 14 2756-61
Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia.
Knudsen ES, Ertel A, Davicioni E, Kline J, Schwartz GF, Witkiewicz AK Breast Cancer Res. Treat. 2012 Jun 133 3 1009-24
RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage.
McClendon AK, Dean JL, Ertel A, Fu Z, Rivadeneira DB, Reed CA, Bourgo RJ, Witkiewicz A, Addya S, Mayhew CN, Grimes HL, Fortina P, Knudsen ES Gastroenterology 2011 Oct 141 4 1439-50
Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment.
Witkiewicz AK, Rivadeneira DB, Ertel A, Kline J, Hyslop T, Schwartz GF, Fortina P, Knudsen ES Am. J. Pathol. 2011 Sep 179 3 1171-8
Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer.
Thangavel C, Dean JL, Ertel A, Knudsen KE, Aldaz CM, Witkiewicz AK, Clarke R, Knudsen ES Endocr. Relat. Cancer 2011 Jun 18 3 333-45
RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo.
Bourgo RJ, Ehmer U, Sage J, Knudsen ES Mol. Biol. Cell 2011 Apr 22 7 931-9
