Gaudenz Danuser, Ph.D. Professor & Chair Endowed Title Patrick E. Haggerty Distinguished Chair in Basic Biomedical Science School Medical School Department Lyda Hill Department of Bioinformatics | Cell Biology Graduate Programs Biomedical Engineering, Cancer Biology Biography Since July 2015, Gaudenz Danuser has been appointed as the inaugural chair of the Lyda Hill Department of Bioinformatics. He holds the Patrick E. Haggerty Distinguished Chair in Basic Biomedical Science and is a Scholar of the Cancer Prevention and Research Institute of Texas (CPRIT). Since March 2021, he is also a member of the Cecil H. and Ida Green Center for Systems Biology. Before moving to UTSW, Danuser directed research laboratories at ETH Zurich (2002 – 2003), at The Scripps Research Institute in La Jolla (2003 – 2009), and at Harvard Medical School (2009 – 2014). Research Interest Causal inference in molecular pathways Cell morphological control of signaling and metabolism Computer vision and machine learning of cell dynamics Roles and regulation of cell morphogenesis in metastasis, especially in pediatric sarcomas Publications Featured Publications Blebs promote cell survival by assembling oncogenic signalling hubs. Weems AD, Welf ES, Driscoll MK, Zhou FY, Mazloom-Farsibaf H, Chang BJ, Murali VS, Gihana GM, Weiss BG, Chi J, Rajendran D, Dean KM, Fiolka R, Danuser G, Nature 2023 Mar 615 7952 517-525 Granger-causal inference of the lamellipodial actin regulator hierarchy by live cell imaging without perturbation. Noh J, Isogai T, Chi J, Bhatt K, Danuser G, Cell Syst 2022 Jun 13 6 471-487.e8 Interpretable deep learning uncovers cellular properties in label-free live cell images that are predictive of highly metastatic melanoma. Zaritsky A, Jamieson AR, Welf ES, Nevarez A, Cillay J, Eskiocak U, Cantarel BL, Danuser G, Cell Syst 2021 May Mechanical regulation of glycolysis via cytoskeleton architecture. Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G, Nature 2020 Feb 578 7796 621-626 Cellular harmonics for the morphology-invariant analysis of molecular organization at the cell surface. Mazloom-Farsibaf H, Zou Q, Hsieh R, Danuser G, Driscoll MK, Nat Comput Sci 2023 Sep 3 9 777-788 SH3BP4 promotes neuropilin-1 and a5-integrin endocytosis and is inhibited by Akt. Burckhardt CJ, Minna JD, Danuser G, Dev Cell 2021 Apr 56 8 1164-1181.e12 Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation. Han SJ, Azarova EV, Whitewood AJ, Bachir A, Guttierrez E, Groisman A, Horwitz AR, Goult BT, Dean KM, Danuser G, Elife 2021 03 10 Actin-Membrane Release Initiates Cell Protrusions. Welf ES, Miles CE, Huh J, Sapoznik E, Chi J, Driscoll MK, Isogai T, Noh J, Weems AD, Pohlkamp T, Dean K, Fiolka R, Mogilner A, Danuser G, Dev Cell 2020 Dec 55 6 723-736.e8 Robust and automated detection of subcellular morphological motifs in 3D microscopy images. Driscoll MK, Welf ES, Jamieson AR, Dean KM, Isogai T, Fiolka R, Danuser G, Nat. Methods 2019 Oct 16 10 1037-1044 Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells. Mohan AS, Dean KM, Isogai T, Kasitinon SY, Murali VS, Roudot P, Groisman A, Reed DK, Welf ES, Han SJ, Noh J, Danuser G, Dev. Cell 2019 May 49 3 444-460.e9 Results 1-10 of 10 1 Honors & Awards Fellow, American Society of Cell Biology (2020) Fellow. American Institute for Medical and Biological Engineering (2018)
