Yunsun Nam is an Assistant Professor in the Department of Obstetrics and Gynecology and the Department of Biophysics. She is a member of the Cecil H. and Ida Green Center for Reproductive Biology Sciences.

Dr. Nam obtained a BA in Biochemical Sciences from Harvard College. Under the direction of Dr. Stephen C. Blacklow, she obtained her PhD in Biological Chemistry and Molecular Pharmacology. Following this, she completed postdoctoral fellowships at Harvard Medical School in Dr. Tom A. Rapoport’s laboratory in the Department of Cell Biology and then in Dr. Piotr Sliz laboratory in the Department of Biological Chemistry and Molecular Pharmacology.

Dr. Nam studies mechanisms of non-coding RNAs and their role in gene regulation important for development and cancer. A major focus is the molecular mechanism and regulation of microRNA processing. She uses various biochemical and biophysical approaches including X-ray crystallography, NMR spectroscopy, molecular biology, nucleic acid/protein biochemistry, high throughput sequencing, and eukaryotic cell-based studies. Her long term goal is not only to elucidate how ncRNAs work but also to identify new avenues for developing therapeutics.


Graduate School
Harvard University (2006)

Research Interest

  • Biochemistry
  • Gene regulation
  • non-coding RNAs
  • Structure and Function of Macromolecular complexes


Featured Publications LegendFeatured Publications

HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing.
Liu H, Liang C, Kollipara RK, Matsui M, Ke X, Jeong BC, Wang Z, Yoo KS, Yadav GP, Kinch LN, Grishin NV, Nam Y, Corey DR, Kittler R, Liu Q Mol. Cell 2016 Jul
Data publication with the structural biology data grid supports live analysis.
Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Christopher Fromme J, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P Nat Commun 2016 7 10882
A grid-enabled web service for low-resolution crystal structure refinement.
O'Donovan DJ, Stokes-Rees I, Nam Y, Blacklow SC, Schröder GF, Brunger AT, Sliz P Acta Crystallogr. D Biol. Crystallogr. 2012 Mar 68 Pt 3 261-7
Conformational locking upon cooperative assembly of notch transcription complexes.
Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC Structure 2012 Feb 20 2 340-9

Honors & Awards

  • Pew Scholar in the Biomedical Sciences
  • Cancer Prevention Research Institute of Texas
    First Time Faculty Recruitment Award (2013)
  • Packard Fellowship for Science and Engineering
    The David and Lucile Packard Foundation (2013)
  • Southwestern Medical Foundation Scholar in Biomedical Research
    Endowed Scholars Program, The University of Texas Southwestern Medical Center (2013)
  • Charles A. King Trust Postdoctoral Research Fellowship
    Charles A. King Trust, N.A., Bank of America, Co‐Trustee. (2011)
  • Damon Runyon Postdoctoral Fellowship
    Damon Runyon Cancer Research Foundation (2007)
  • The Jane Coffin Childs Postdoctoral Fellowship
    The Jane Coffin Childs Memorial Fund for Medical Research (declined) (2007)