Luis Sifuentes-Dominguez, M.D. Titles and Appointments Assistant Professor Schools Medical School Departments Pediatrics You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Dr. Luis Sifuentes-Dominguez is studying basic mechanisms of inflammatory bowel disease. He is supported by a departmental, NIH-sponsored Child Health Research Career Development Award and is working closely with Dr. Ezra Burstein in UT Southwestern’s Department of Internal Medicine’s Division of Gastroenterology to understand the molecular basis of early-onset IBD. Using cutting-edge genomic and proteomic approaches, together they have identified novel genes that play a role in early-onset IBD. Education Medical School Universidad La Salle Medical School (2005) Residency Hospital Infantil de Mexico Federico Gomez (2008), Pediatrics Residency University of Connecticut Health Center (2012), Pediatrics Fellowship UT Southwestern/Children's Medical Center (2015), Pediatric Gastroenterology Research Interest Identifying the genetic causes of early onset Inflammatory Bowel Disease Role of enteroendocrine cells in inflammatory bowel disease pathogenesis Publications Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism Tan S, Santolaya JL, Wright TF, Liu Q, Fujikawa T, Chi S, Bergstrom CP, Lopez A, Chen Q, Vale G, McDonald JG, Schmidt A, Vo N, Kim J, Baniasadi H, Li L, Zhu G, He TC, Zhan X, Obata Y, Jin A, Jia D, Elmquist JK, Sifuentes-Dominguez L, Burstein E Nature Metabolism 2024 Jun 6 1076-1091 Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection Hu Z, Zhang C, Sifuentes-Dominguez L, Zarek CM, Propheter DC, Kuang Z, Wang Y, Pendse M, Ruhn KA, Hassell B, Behrendt CL, Zhang B, Raj P, Harris-Tryon TA, Reese TA, Hooper LV Science 2021 Nov 374 Augmented ustekinumab dosing is needed to achieve clinical response in patients with anti-TNF refractory pediatric Crohn's disease: A retrospective chart review Do P, Andersen J, Patel A, Semrin G, Sifuentes-Dominguez L, Luu P, Gurram B F1000Research 2021 9 Paneth cell-derived growth factors support tumorigenesis in the small intestine Chen Q, Suzuki K, Sifuentes-Dominguez L, Miyata N, Song J, Lopez A, Starokadomskyy P, Gopal P, Dozmorov I, Tan S, Ge B, Burstein E Life Science Alliance 2020 Dec 4 In-vitro GLP-1 Release Assay Using STC-1 Cells Qi L, Shuai T, Da J, Ezra B, Luis SD Bio-protocol 2020 Aug 10 Structural and mechanistic insights into secretagogin-mediated exocytosis Qin J, Liu Q, Liu Z, Pan YZ, Sifuentes-Dominguez L, Stepien KP, Wang Y, Tu Y, Tan S, Wang Y, Sun Q, Mo X, Rizo J, Burstein E, Jia D Proceedings of the National Academy of Sciences of the United States of America 2020 Mar 117 6559-6570 NK cell defects in X-linked pigmentary reticulate disorder Starokadomskyy P, Wilton KM, Krzewski K, Lopez A, Sifuentes-Dominguez L, Overlee B, Chen Q, Ray A, Gil-Krzewska A, Peterson M, Kinch LN, Rohena L, Grunebaum E, Zinn AR, Grishin NV, Billadeau DD, Burstein E JCI Insight 2019 Nov 4 Mosaic tetrasomy 9p associated with inflammatory bowel disease Sifuentes-Dominguez L, Starokadomskyy P, Welch J, Gurram B, Park JY, Koduru P, Burstein E Journal of Crohn's and Colitis 2019 Oct 13 1474-1478 SCGN deficiency results in colitis susceptibility Sifuentes-Dominguez L, Li H, Llano E, Liu Z, Singla A, Patel AS, Kathania M, Khoury A, Norris N, Rios JJ, Starokadomskyy P, Park JY, Gopal P, Liu Q, Tan S, Chan L, Ross T, Harrison S, K V, Baker LA, Jia D, Burstein E eLife 2019 Oct 8 Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer Zhu W, Miyata N, Winter MG, Arenales A, Hughes ER, Spiga L, Kim J, Sifuentes-Dominguez L, Starokadomskyy P, Gopal P, Byndloss MX, Santos RL, Burstein E, Winter SE Journal of Experimental Medicine 2019 216 2378-2393 Results 1-10 of 16 1 2 Next Last Honors & Awards Excellence in Research AwardUTSW Department of Pediatrics Senior Fellows Research Day (2015) W.W. Caruth ScholarChildren's Medical Center Foundation (2015) Endoscopy PrizeNASPGHAN (2014) Teaching Resident AwardUniversity of Connecticut School of Medicine (2012) Professional Associations/Affiliations Crohn's and Colitis Foundation of America, North Texas Dallas Chapter Medical Advisory Committee (2016) Member, Crohn's and Colitis Foundation of America (2014) Member, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (2012)
