Michael Jessen, M.D.

Michael E. Jessen, M.D. was born and raised in Canada. After graduating from the University of Manitoba School of Medicine in Winnipeg, Canada, he began residency training in General Surgery at the University of Manitoba in Winnipeg, completing this program in 1986. He then spent two years in the Surgical Research Laboratory of Dr. Andrew Wechsler at Duke University studying myocardial metabolism and the biochemistry of myocardial protection. He was awarded a research fellowship from the Canadian Heart Foundation during this time. In 1988 he was invited to join the Residency Program in Thoracic Surgery at Duke University Medical Center and trained there under the direction of Dr. David C. Sabiston, Jr., completing his residency in 1990. He then joined the faculty of the University of Texas Southwestern Medical Center at Dallas, where he remains today as Professor and Chairman of the Department of Cardiovascular and Thoracic Surgery. He is the holder of The Frank M. Ryburn, Jr., Distinguished Chair in Cardiothoracic Surgery and Transplantation. Dr. Jessen directs an active basic research laboratory that has received funding from the National Institutes of Health, the American Heart Association, and the Texas Advanced Technology Program. His research examines myocardial metabolism, the effects of cardiopulmonary bypass and and a novel technique for long-term cardiac preservation for transplantation. This work has yielded a broad array of publications in the literature. In 1994 he received the Lyndon Baines Johnson Research Award of the Texas Affiliate of the American Heart Association. Dr. Jessen is the Director of the Residency Program in Thoracic Surgery at UT Southwestern and teaches in the Biomedical Engineering Program at Southwestern Graduate School. He has an active clinical practice that focuses on cardiac surgery, surgical electrophysiology, aortic surgery, and cardiac transplantation.

Medical School	University of Manitoba (1981)
Internship	University of Manitoba (1982)
Residency	University of Manitoba (1986)
Fellowship	Duke University Hospital (1988)
Residency	Duke University Hospital (1990)

• Cardiothoracic Surgery
• Heart (Cardiology)
• Surgery
• Thoracic Surgery

• Primary Interests
• Aortic Aneurysm Repair
• Aortic Dissection
• Aortic Stent
• Aortic Valve Disease, Stenosis & Regurgitation
• Arrythmia Surgery
• Atrial Septal Defect (ASD) Closure
• Blocked Artery Surgery
• Cardiac Transplantation
• Cardiac, Cardiothoracic & Cardiovascular Surgery
• Cardiovascular Disease
• Coarctation of the Aorta
• Coronary Artery Bypass Graft (CABG) Surgery
• Heart Bypass Surgery
• Heart Surgery
• Heart Transplant
• Heart Tumor
• Heart Valve Repair
• Heart Valve Surgery
• Maze Procedure
• Minimally Invasive Heart Surgery
• Mitral Valve Disease, Stenosis & Regurgitation
• Mitral Valve Repair
• Open Heart Surgery
• Pacemaker Insertion
• Patent Ductus Arteriosus
• Patent Foramen Ovale (PFO)Closure
• Surgical Arrythmia Ablation
• Surgical Stents
• Thoracic Aortic Surgery
• Tricuspid Atresia
• Tricuspid Valve Disease
• Tricuspid Valve Surgery
• Ventricular Aneurysm

• Biocompatibility of materials for cardiopulmonary bypass and effects of the inflammatory response to extracorporeal circulation
• Dynamic organ preservation with continuous perfusion
• Metabolic mechanisms of myocardial protection and the effects of substrate modifications on organ protective strategies

Featured Publications

Impact of recipient age and procedure type on survival following lung transplantation for interstitial pulmonary fibrosis

Meyer DM, Edwards LB, Torres F, Jessen ME, Novik RJ Ann Thorac Surg 2005 79 950-0

Myocardial oxygen demand and redox state affect fatty acid oxidation in the potassium arrested heart

Peltz M, He TT, Adams GA, Chao RY, Jessen ME Surgery 2004 136 150-159

Antifibrinolytic Therapy During Cardiopulmonary Bypass Reduces Proinflammatory cytokine levels: A randomized, double-blind placebo-controlled study of e-Aminocaproic acid and aprotinin

Greilich PE, Brouse CF, Whitten CW, Chi L, DiMaio JM, Jessen ME J Thorac Cardiovasc Surg 2003 126 1498-1503

Extracorporeal Life Support

Meyer DM, Jessen ME 2001

Effects of amino acids on substrate selection, anaplerosis and left ventricular function in the ischemic reperfused rat heart

Jessen ME, Kovarik TE, Jeffrey FM, Sherry AD, Storey CJ, Chao RY, Ring WS, Malloy CR J Clinical Invest Spring 1993 92 831-839

Perfusion preservation vs. static preservation for cardiac transplantation: Effects on myocardial function and metabolism

Rosenbaum DH, Peltz M, DiMaio JM, Meyer DM, Wait MA, Merritt ME, Brown R, Chao RY, Ring WS, Jessen ME Journal of Heart Lung Transplantation 2008 Volume 27 93-99

Benefits of perfusion preservation in canine hearts stored for short intervals.

Rosenbaum, DH, Peltz, M, Merritt, ME, Thatcher, JE, Sasaki, H, Jessen, ME J Surg Research 2007 140 243-249

Hypothermic circulatory arrest for repair of injuries of the thoracic aorta and great vessels

Peltz M, Douglass D, Meyer DM, Wait MA, DiMaio JM, Ring WS, Jessen ME Interact Cardiovasc Thorac Surg 2006 5 560-565

Pyruvate-modified Perfadex improves lung function after long-term hypothermic storage

Peltz M He TT, Adams GA, Chao RY, Jessen ME, Meyer DM J Heart Lung Transplantation 2005 24 896-903

Perfusion preservation maintains myocardial ATP levels and reduces apoptosis in an ex-vivo rat heart transplantation model

Peltz M, He TT, Adams GA, Koshy S, Burgess SC, Chao RY, Meyer DM, Jessen ME Surgery 2005 138 795-805

• Lyndon Baines Johnson Research Award
  American Heart Association, Texas Affiliate (1994)
• Harold Micay Surgical Resident Award
  University of Manitoba (1985)
• Davis and Geck Surgical Resident Award
  University of Manitoba (1984)
• Maxwell Rady Scholarship
  University of Manitoba (1977)
• Isbister Scholarship
  University of Manitoba (1976)

• American Association for Thoracic Surgery
• American Heart Association, Council on Cardiothoracic and Vascular Surgery
• Royal College of Physicians and Surgeons of Canada
• Society of Thoracic Surgeons
• Thoracic Surgery Directors Association