Download Curriculum Vitae

The Lab of Dr. Zhu seeks to determine the genetic and cellular factors that influence liver regeneration and cancer, and to ask if these factors are common to both processes. Given the liver's potent ability to maintain itself in the face of toxic injury, the lab is also investigating the protective mechanisms that might suppress cancer formation in the liver. 

Dr. Zhu grew up in North Carolina and earned a Bachelor of Science degree in biology from Duke University, followed by an M.D. degree from Harvard Medical School and MIT. After completing his M.D. training, he underwent training in internal medicine at University of California, San Francisco and Medical Oncology at the Dana-Farber Cancer Institute. From 2008 to 2012, Dr. Zhu performed postdoctoral research at Boston Children's Hospital, exploring connections between microRNAs, metabolism and regeneration in mouse models. In 2012, he joined the faculty of UT Southwestern. He is also an attending physician at Parkland Memorial Hospital.


Medical School
Harvard Medical School (2005)
University of California, San Francisco (2007), Internal Medicine
Dana-Farber Cancer Institute (2011), Hematology Oncology

Research Interest

  • Liver cancer
  • Mechanisms of organ regeneration
  • RNA biology


Featured Publications LegendFeatured Publications

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA.
Miller JB, Zhang S, Kos P, Xiong H, Zhou K, Perelman SS, Zhu H, Siegwart DJ Angew. Chem. Int. Ed. Engl. 2016 Dec
Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model.
Zhou K, Nguyen LH, Miller JB, Yan Y, Kos P, Xiong H, Li L, Hao J, Minnig JT, Zhu H, Siegwart DJ Proc. Natl. Acad. Sci. U.S.A. 2016 Jan 113 3 520-5

Honors & Awards

  • SU2C Innovative Research Grant
  • Burroughs Wellcome Fund Career Award for Medical Scientists
  • CPRIT Scholar in Cancer Research
  • Magna cum laude and James Tolbert Shipley Prize for MD Honors Thesis, Harvard Medical School