Download Curriculum Vitae

The Lab of Dr. Zhu seeks to determine the genetic and cellular factors that influence liver regeneration and cancer, and to ask if these factors are common to both processes. Given the liver's potent ability to maintain itself in the face of toxic injury, the lab is also investigating the protective mechanisms that might suppress cancer formation in the liver. 

Dr. Zhu grew up in North Carolina and earned a Bachelor of Science degree in biology from Duke University, followed by an M.D. degree from Harvard Medical School and MIT. After completing his M.D. training, he underwent training in internal medicine at University of California, San Francisco and Medical Oncology at the Dana-Farber Cancer Institute. From 2008 to 2012, Dr. Zhu performed postdoctoral research at Boston Children's Hospital, exploring connections between microRNAs, metabolism and regeneration in mouse models. In 2012, he joined the faculty of UT Southwestern. He is also an attending physician at Parkland Memorial Hospital.


Medical School Harvard Medical School (2005)
Residency University of California, San Francisco (2007), Internal Medicine
Fellowship Dana-Farber Cancer Institute (2011), Hematology & Oncology

Research Interest

  • Liver cancer
  • Mechanisms of organ regeneration
  • RNA biology


Featured Publications LegendFeatured Publications

Fetal Deficiency of Lin28 Programs Life-Long Aberrations in Growth and Glucose Metabolism.
Shinoda G, Shyh-Chang N, de Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ Stem Cells 2013 May
A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.
Nishino J, Kim S, Zhu Y, Zhu H, Morrison SJ Elife 2013 2 0
Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation.
Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC Science 2012 Nov
Identification of adult nephron progenitors capable of kidney regeneration in zebrafish.
Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ Nature 2011 Feb 470 7332 95-100

Honors & Awards

  • Burroughs Wellcome Fund Career Award for Medical Scientists
  • CPRIT Scholar in Cancer Research
  • Forbeck Scholar Award
  • Magna cum laude and James Tolbert Shipley Prize for MD Honors Thesis, Harvard Medical School