The Lab of Dr. Zhu seeks to determine the genetic and cellular factors that influence liver regeneration and cancer, and to ask if these factors are common to both processes. Given the liver's potent ability to maintain itself in the face of toxic injury, the lab is also investigating the protective mechanisms that might suppress cancer formation in the liver.
Dr. Zhu grew up in North Carolina and earned a Bachelor of Science degree in biology from Duke University, followed by an M.D. degree from Harvard Medical School and MIT. After completing his M.D. training, he underwent training in internal medicine at University of California, San Francisco and Medical Oncology at the Dana-Farber Cancer Institute. From 2008 to 2012, Dr. Zhu performed postdoctoral research at Boston Children's Hospital, exploring connections between microRNAs, metabolism and regeneration in mouse models. In 2012, he joined the faculty of UT Southwestern. He is also an attending physician at Parkland Memorial Hospital.
- Medical School
- Harvard Medical School (2005)
- University of California, San Francisco (2007), Internal Medicine
- Dana-Farber Cancer Institute (2011), Hematology Oncology
- Liver cancer
- Mechanisms of organ regeneration
- RNA biology
- Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment.
- Zhu H, Celen C, Chuang JC, Luo X, Nijem N, Walker AK, Chen F, Zhang S, Chung AS, Nguyen LH, Nassour I, Budhipramono A, Sun X, Bok LA, McEntagart M, Gevers E, Birnbaum SG, Eisch AJ, Powell CM, Ge WP, Santen GW, Chahrour M Elife 2017 Jul 6
- Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration.
- Sun X, Chuang JC, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer RA, Sorouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo YC, Wang Z, Xing C, Zhu H Cell Stem Cell 2016 Mar
- Precise let-7 expression levels balance organ regeneration against tumor suppression.
- Wu L, Nguyen LH, Zhou K, de Soysa TY, Li L, Miller JB, Tian J, Locker J, Zhang S, Shinoda G, Seligson MT, Zeitels LR, Acharya A, Wang SC, Mendell JT, He X, Nishino J, Morrison SJ, Siegwart DJ, Daley GQ, Shyh-Chang N, Zhu H Elife 2015 Oct 4
- Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models.
- Nguyen LH, Robinton DA, Seligson MT, Wu L, Li L, Rakheja D, Comerford SA, Ramezani S, Sun X, Parikh MS, Yang EH, Powers JT, Shinoda G, Shah SP, Hammer RE, Daley GQ, Zhu H Cancer Cell 2014 Aug 26 2 248-61
- TALEN mediated somatic mutagenesis in murine models of cancer.
- Zhang S, Li L, Kendrick SL, Gerard RD, Zhu H Cancer Res. 2014 Jul
- Lin28 enhances tissue repair by reprogramming cellular metabolism.
- Shyh-Chang N, Zhu H, Yvanka de Soysa T, Shinoda G, Seligson MT, Tsanov KM, Nguyen L, Asara JM, Cantley LC, Daley GQ Cell 2013 Nov 155 4 778-92
- The Lin28/let-7 axis regulates glucose metabolism.
- Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI, Altshuler D, Daley GQ Cell 2011 Sep 147 1 81-94
- Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.
- Zhu H, Shah S, Shyh-Chang N, Shinoda G, Einhorn WS, Viswanathan SR, Takeuchi A, Grasemann C, Rinn JL, Lopez MF, Hirschhorn JN, Palmert MR, Daley GQ Nat. Genet. 2010 Jul 42 7 626-30
- Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA.
- Miller JB, Zhang S, Kos P, Xiong H, Zhou K, Perelman SS, Zhu H, Siegwart DJ Angew. Chem. Int. Ed. Engl. 2016 Dec
- Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model.
- Zhou K, Nguyen LH, Miller JB, Yan Y, Kos P, Xiong H, Li L, Hao J, Minnig JT, Zhu H, Siegwart DJ Proc. Natl. Acad. Sci. U.S.A. 2016 Jan 113 3 520-5
Honors & Awards
- SU2C Innovative Research Grant
- Burroughs Wellcome Fund Career Award for Medical Scientists
- CPRIT Scholar in Cancer Research
- Magna cum laude and James Tolbert Shipley Prize for MD Honors Thesis, Harvard Medical School