John Schoggins, Ph.D.

Assistant Professor

Endowed Title: Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell

Department: Microbiology

Graduate Programs: Molecular Microbiology

Education

Undergraduate University of Rochester (2000), Chemistry
Graduate School Cornell University Medical College (2007), Molecular Cell Biology

Research Interests

  • influence of host genetic variation on viral pathogenesis
  • innate immunity to viral infections
  • screening and fluorescent/luminescent reporter technologies
  • virus-host interactions

Publications

Featured Publications Legend

Featured Publications

MX2 is an interferon-induced inhibitor of HIV-1 infection.

Kane M, Yadav SS, Bitzegeio J, Kutluay SB, Zang T, Wilson SJ, Schoggins JW, Rice CM, Yamashita M, Hatziioannou T, Bieniasz PD Nature 2013 Oct

IFNß-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage.

Cheon H, Holvey-Bates EG, Schoggins JW, Forster S, Hertzog P, Imanaka N, Rice CM, Jackson MW, Junk DJ, Stark GR EMBO J. 2013 Sep

Inhibition of HIV-1 particle assembly by 2',3'-cyclic-nucleotide 3'-phosphodiesterase.

Wilson SJ, Schoggins JW, Zang T, Kutluay SB, Jouvenet N, Alim MA, Bitzegeio J, Rice CM, Bieniasz PD Cell Host Microbe 2012 Oct 12 4 585-97

Mycobacterial disease and impaired IFN-? immunity in humans with inherited ISG15 deficiency.

Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D, Salem S, Radovanovic I, Grant AV, Adimi P, Mansouri N, Okada S, Bryant VL, Kong XF, Kreins A, Velez MM, Boisson B, Khalilzadeh S, Ozcelik U, Darazam IA, Schoggins JW, Rice CM, Al-Muhsen S, Behr M, Vogt G, Puel A, Bustamante J, Gros P, Huibregtse JM, Abel L, Boisson-Dupuis S, Casanova JL Science 2012 Sep 337 6102 1684-8

Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro.

Schoggins JW, Dorner M, Feulner M, Imanaka N, Murphy MY, Ploss A, Rice CM Proc. Natl. Acad. Sci. U.S.A. 2012 Sep 109 36 14610-5

C7L family of poxvirus host range genes inhibits antiviral activities induced by type I interferons and interferon regulatory factor 1.

Meng X, Schoggins J, Rose L, Cao J, Ploss A, Rice CM, Xiang Y J. Virol. 2012 Apr 86 8 4538-47

Multiple interferon stimulated genes synergize with the zinc finger antiviral protein to mediate anti-alphavirus activity.

Karki S, Li MM, Schoggins JW, Tian S, Rice CM, MacDonald MR PLoS ONE 2012 7 5 e37398

Interferon-stimulated genes and their antiviral effector functions.

Schoggins JW, Rice CM Curr Opin Virol 2011 Dec 1 6 519-25

A genetically humanized mouse model for hepatitis C virus infection.

Dorner M, Horwitz JA, Robbins JB, Barry WT, Feng Q, Mu K, Jones CT, Schoggins JW, Catanese MT, Burton DR, Law M, Rice CM, Ploss A Nature 2011 Jun 474 7350 208-11

A diverse range of gene products are effectors of the type I interferon antiviral response.

Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM Nature 2011 Apr 472 7344 481-5

Results 1-10 of 14

Honors/Awards

  • Seymour and Vivian Milstein Young Investigator Award
    (2013)
  • NIH K01 Career Development Award
    (2012)
  • Sidney & Joan Pestka Award for Excellence in Interferon Research
    (2011)