Biography

Dr. Daniel J. Siegwart obtained his Ph.D. at Carnegie Mellon University (CMU) under the guidance of Prof. Krzysztof Matyjaszewski, who developed Atom Transfer Radical Polymerization (ATRP), one of the most powerful Controlled/living Radical Polymerization (CRP) techniques.  One of Dan's main projects involved combining ATRP with radical ring-opening polymerization to produce injectable degradable polymers and hydrogels for bone fracture repair.  He also co-developed ATRP in inverse miniemulsion to produce nanogels for drug delivery.  Dan received the Joseph A. Solomon Memorial Fellowship in Chemistry at CMU and was also awarded a National Science Foundation (NSF) East Asia and Pacific Summer Institutes (EAPSI) Fellowship to study at the University of Tokyo with Prof. Kazunori Kataoka in 2006.  

In order to apply his background in polymer chemistry to translational medical applications, Dan conducted NIH NRSA-sponsored postdoctoral research with Prof. Robert Langer at MIT and focused on combinatorial, high-throughput methods in material discovery.  There, he directed a project reporting the first large library of 1,536 structurally defined core-shell nanoparticles that identified key chemical functionalities for designing polymers for siRNA delivery. Dan also worked on the automated synthesis of non-fouling zwitterionic materials for cell encapsulation to treat diabetes, injectable materials to treat spinal cord injuries, and catalyst development for the automated synthesis of thiol-functionalized polymers for siRNA conjugation. 

At the University of Texas Southwestern Medical Center, the Siegwart Research Group’s long-term goals are to develop new materials for therapuetic nucleic acid delivery (siRNA, miRNA, mRNA, CRISPR), develop new polymers to deliver chemotherapeutic drugs to hypovascular tumors, develop theranostic "turn on" probes, and to globally understand how the physical and chemical properties of materials affect interactions with biological systems in vitro and in vivo in the context of improving cancer therapies.  They aspire to utilize chemistry and engineering to make a beneficial impact on human health.

Education

Undergraduate
Lehigh University (2003), Biochemistry
Graduate School
Carnegie Mellon University (2005), Chemistry
Graduate School
Carnegie Mellon University (2008), Chemistry

Publications

Featured Publications LegendFeatured Publications

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model.
Zhou K, Nguyen LH, Miller JB, Yan Y, Kos P, Xiong H, Li L, Hao J, Minnig JT, Zhu H, Siegwart DJ Proc. Natl. Acad. Sci. U.S.A. 2016 Jan 113 3 520-5
Rapid synthesis of a lipocationic polyester library via ring-opening polymerization of functional valerolactones for efficacious siRNA delivery
Jing Hao, Petra Kos, Kejin Zhou, Jason B. Miller, Lian Xue, Yunfeng Yan, Hu Xiong, Sussana Elkassih, and Daniel J. Siegwart* Journal of the American Chemical Society 2015 137 9206-9209
Scalable synthesis and derivation of functional polyesters bearing ene and epoxide side chains
Yunfeng Yan and Daniel J. Siegwart Polymer Chemistry 2014 5
ATRP in the design of functional materials for biomedical applications.
Siegwart DJ, Oh JK, Matyjaszewski K Prog Polym Sci 2012 Jan 37 1 18-37
Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery.
Siegwart DJ, Whitehead KA, Nuhn L, Sahay G, Cheng H, Jiang S, Ma M, Lytton-Jean A, Vegas A, Fenton P, Levins CG, Love KT, Lee H, Cortez C, Collins SP, Li YF, Jang J, Querbes W, Zurenko C, Novobrantseva T, Langer R, Anderson DG Proc. Natl. Acad. Sci. U.S.A. 2011 Aug 108 32 12996-3001