Daniel Siegwart, Ph.D. Professor Endowed Title W. Ray Wallace Distinguished Chair in Molecular Oncology Research School Medical School Department Biomedical Engineering | Biochemistry | Harold C. Simmons Comprehensive Cancer Center Graduate Programs Organic Chemistry, Biomedical Engineering Biography Daniel J. Siegwart is a Professor in the Department of Biomedical Engineering, Department of Biochemistry, and the Simmons Comprehensive Cancer Center (SCCC) at the University of Texas Southwestern Medical Center. He holds the W. Ray Wallace Distinguished Chair in Molecular Oncology Research and serves as the Director of the Program in Genetic Drug Engineering, Director of the Drug Delivery Program in Biomedical Engineering, and Co-leader of the Chemistry and Cancer Program in the NCI-designated SCCC. He received a B.S. in Biochemistry from Lehigh University (2003), and a Ph.D. in Chemistry from Carnegie Mellon University (2008), studying with Professor Krzysztof Matyjaszewski. He also studied as an NSF EAPSI Research Fellow at the University of Tokyo with Professor Kazunori Kataoka (2006). He then completed an NIH NSRA Postdoctoral Fellowship at MIT with Professor Robert Langer (2008-2012). He has received awards including a CPRIT Scholar Award, an American Cancer Society Research Scholar Award, the Young Innovator Award in Nanobiotechnology, Biomaterials Science Emerging Investigator Award, and election to the Controlled Release Society (CRS) College of Fellows and the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows. His research laboratory utilizes materials chemistry to enable targeted nanoparticle delivery of genomic medicines. Their efforts led to an understanding of the essential physical and chemical properties of synthetic carriers required for therapeutic delivery of siRNA, miRNA, tRNA, pDNA, mRNA, and gene editors. His lab has been at the forefront in the design of synthetic carriers for gene editing and has applied these technologies for correction of genetic diseases and treatment of cancer. They reported the first non-viral system for in vivo CRISPR/Cas gene editing. They developed Selective ORgan Targeting (SORT) lipid nanoparticles (LNPs), which was the first strategy for predictable tissue specific mRNA delivery and gene editing. They ultimately aspire to utilize chemistry and engineering to make a beneficial impact on human health. Education Undergraduate Lehigh University (2003), Biochemistry Graduate School Carnegie Mellon University (2005), Chemistry Graduate School Carnegie Mellon University (2008), Chemistry Publications Featured Publications In vivo editing of lung stem cells for durable gene correction in mice. Sun Y, Chatterjee S, Lian X, Traylor Z, Sattiraju SR, Xiao Y, Dilliard SA, Sung YC, Kim M, Lee SM, Moore S, Wang X, Zhang D, Wu S, Basak P, Wang J, Liu J, Mann RJ, LePage DF, Jiang W, Abid S, Hennig M, Martinez A, Wustman BA, Lockhart DJ, Jain R, Conlon RA, Drumm ML, Hodges CA, Siegwart DJ, Science 2024 Jun 384 6701 1196-1202 On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles. Dilliard SA, Cheng Q, Siegwart DJ, Proc Natl Acad Sci U S A 2021 Dec 118 52 Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing. Liu S, Cheng Q, Wei T, Yu X, Johnson LT, Farbiak L, Siegwart DJ, Nat Mater 2021 May 20 5 701-710 Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing. Wei T, Cheng Q, Min YL, Olson EN, Siegwart DJ, Nat Commun 2020 06 11 1 3232 Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing. Cheng Q, Wei T, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ, Nat Nanotechnol 2020 04 15 4 313-320 Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA. Miller JB, Zhang S, Kos P, Xiong H, Zhou K, Perelman SS, Zhu H, Siegwart DJ Angew. Chem. Int. Ed. Engl. 2016 Dec Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Zhou K, Nguyen LH, Miller JB, Yan Y, Kos P, Xiong H, Li L, Hao J, Minnig JT, Zhu H, Siegwart DJ Proc. Natl. Acad. Sci. U.S.A. 2016 Jan 113 3 520-5 Rapid synthesis of a lipocationic polyester library via ring-opening polymerization of functional valerolactones for efficacious siRNA delivery Jing Hao, Petra Kos, Kejin Zhou, Jason B. Miller, Lian Xue, Yunfeng Yan, Hu Xiong, Sussana Elkassih, and Daniel J. Siegwart* Journal of the American Chemical Society 2015 137 9206-9209 Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells. Lian X, Chatterjee S, Sun Y, Dilliard SA, Moore S, Xiao Y, Bian X, Yamada K, Sung YC, Levine RM, Mayberry K, John S, Liu X, Smith C, Johnson LT, Wang X, Zhang CC, Liu DR, Newby GA, Weiss MJ, Yen JS, Siegwart DJ, Nat Nanotechnol 2024 May Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes. Liu S, Wang X, Yu X, Cheng Q, Johnson LT, Chatterjee S, Zhang D, Lee SM, Sun Y, Lin TC, Liu JL, Siegwart DJ, J Am Chem Soc 2021 Dec 143 50 21321-21330 Results 1-10 of 29 1 2 3 Next Last Honors & Awards National Academy of Medicine (NAM) Emerging Leaders in Health and Medicine (ELHM) Scholar (2024-2024) Controlled Release Society (CRS) College of Fellows (2023-2023) American Institute for Medical and Biological Engineering (AIMBE)College of Fellows (2022-2022) W. Ray Wallace Distinguished Chair in Molecular Oncology Research (2022-2022) Chinese Institute of Engineers Special Recognition Award (2021-2021) Howard Hughes Medical Institute (HHMI) Gilliam Fellow for Advanced Study (advisor-student pair) (2021-2021) Biomaterials Science Emerging Investigator (2019-2019) Young Innovator Award in Nanobiotechnology (2018-2018) American Cancer Society (ACS) Research Scholar (2017-2017) Friends of the Comprehensive Cancer Center Award (2014-2014) Cancer Prevention and Research Institute of Texas (CPRIT) Scholar Award (2012-2016) National Institutes of Health (NIH) Ruth L. Kirschstein National Research Service Award (NRSA) F32 Postdoctoral Fellowship (2010-2012) National Science Foundation (NSF) East Asia and Pacific Summer Institutes (EAPSI) Fellowship (2006-2006) The Joseph S. Solomon Memorial Fellowship in Chemistry, Carnegie Mellon University (2005-2008) Chemistry Department Research Honors, Lehigh University (2003-2003) Professional Associations/Affiliations Chair of Scientific Advisory Board at Recode Therapeutics (2022) Co-Founder Recode Therapeutics (2015-2015) Member of Scientific Advisory Board at Tome Biosciences (2022) NSF EAPSI Research Fellow Department of Materials Engineering (2006-2006) Synthetic Chemistry Intern (2002-2002)
