A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening
Hattori M*, Hibbs RE*, Gouaux E (*Equal contribution) Structure 2012 8 20
Principles of activation and permeation in an anion-selective Cys-loop receptor.
Hibbs RE, Gouaux E Nature 2011 Jun 474 7349 54-60
Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor.
Hibbs RE, Sulzenbacher G, Shi J, Talley TT, Conrod S, Kem WR, Taylor P, Marchot P, Bourne Y EMBO J. 2009 Oct 28 19 3040-51
Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore.
Talley TT, Harel M, Hibbs RE, Radic Z, Tomizawa M, Casida JE, Taylor P Proc. Natl. Acad. Sci. U.S.A. 2008 May 105 21 7606-11
Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes.
Taylor P, Talley TT, Radic' Z, Hansen SB, Hibbs RE, Shi J Biochem. Pharmacol. 2007 Oct 74 8 1164-71
Influence of agonists and antagonists on the segmental motion of residues near the agonist binding pocket of the acetylcholine-binding protein
Hibbs RE, Radic Z, Taylor P, Johnson DA J Biol Chem 2006 51 281 39708-18
Structural dynamics of the alpha-neurotoxin-acetylcholine-binding protein complex: hydrodynamic and fluorescence anisotropy decay analyses.
Hibbs RE, Johnson DA, Shi J, Hansen SB, Taylor P Biochemistry 2005 Dec 44 50 16602-11
Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine-binding protein.
Hibbs RE, Talley TT, Taylor P J. Biol. Chem. 2004 Jul 279 27 28483-91
Contemporary paradigms for cholinergic ligand design guided by biological structure
Taylor P, Hansen SB, Talley TT, Hibbs RE, Radić Z Bioorg Med Chem Lett 2004 8 14 1875-7