Jer-Tsong Hsieh, Ph.D.

Education: National Taiwan University, Taipei, Taiwan; BS, Plant Pathology; National Yang-Ming Medical School, Taipei, Taiwan; MS, Microbiology and Immunology; University of Wisconsin-Madison, Madison, Wisconsin, PhD, Human Cancer Biology; University of Texas, M.D. Anderson Cancer Center, Houston, Texas, Research Fellow.

Dr. Hsieh is currently an Associate professor and Director of Jean H. and John T. Walter, Jr., Center for Research in Urologic Oncology in the Department of Urology at UT Southwestern. Dr. Hsieh has many years experience in studying tumor biology and cancer progression of urogenital cancers, particularly, prostate and bladder cancers. Currently, his research focuses on translational research with two main topics: one is to identify signal defects leading to androgen-independent prostate cancer progression and bladder cancer metastasis; the other is to develop gene therapeutic modalities. Dr. Hsieh has six nationally funded research grants on these subjects. He is collaborating with Urologists and Medical Oncologists for future clinical trials.

Graduate School	National Yang-ming Medical College ()
Graduate School	University of Wisconsin-madison (1989)

• Bladder cancer gene therapy
• Prostate stem cell
• Signal network defects in prostate cancer
• Small molecular therapy

Featured Publications

Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder

Karam, J. A., Shariat, S.F., Huang, H-Y., Ashfaq, R., Shapiro, E., Lotan, Y., Sagalowsky, A.I., and Hsieh, J.T. Clin. Cancer Res. 2007 13 4400-4406

Mechanism of increased coxsackie and adenovirus receptor gene expression and adenovirus uptake by phytoestrogen and histone deacetykase inhibitor in human bladder cancer cells and the potential clinical application

Pong, R.C., Roark, R., Ou, J., Fan, J., Stanfield, J., Frenkel, E., Sagalowsky, A., and Hsieh, J.T. Cancer Res. 2006 66 8822-8828

The Potential Application of Epigenetic Modifiers in the Treatment of Prostate and Bladder Cancer

Zhang, Z., Karam, J., Frenkel, E.P., Sagalowsky, A., and Hsieh, J.T. Urologic Oncol. 2006 24 152-160

Inhibition of mitogens-elicited signal transduction and growth in prostate cancer with a small peptide derived from the functional domain of DOC-2/DAB2 delivered by a unique vehicle

Zhou, J., Fan, J., and Hsieh, J.T. Cancer Res. 2006 66 8822-8828

Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer

Chen H, Tu SW, Hsieh JT JBC June 2005 280 22437-22444

The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-Azacytidine in human bladder cancer therapy

Karam, J.A., Fan, J., Stanfield, J., Richer, E., Benaim, E.A., Frenkel, E.P., Sagalowsky, A.I., Antich, P.P., Mason, R.P., and Hsieh, J.T. Int. J. Cancer 2007 120 1795-1802

Histone deacetylase inhibitor (FK228) enhances the therapeutic efficacy of docetaxel in androgen independent prostate cancer

Zhang, Z., Stanfield, J., Frenkel, E.P., and Hsieh, J.T. Urol. 2007 In press

A histone deacetylase inhibitor enhances adenoviral infection of renal cancer cells

Okegawa, T., Sayne, J.R., Nutahara, K., Pong, R.C., Saboorian, H., Kabbani, W., Higashihara, E., and Hsieh, J.T. J. Urol. 2007 177 1163-1168

Cloning of mDAB2IP gene, a novel member of the RasGTPase-activating protein family and characterization of its regulatory region

Chen, H, Karam. J.A., Schultz, R., Zhang, Z., Ducan, C., and Hsieh, J.T. DNA and Cell Biol. 2006 25 232-245

The mechanism of antiandrogen effect of DOC-2/DAB2 on androgen receptor-mediated cell growth in androgen independent prostate cancer

Zhou, J., Hernandez, G., Tu, S., Huang, C.L., Tseng, C.P., and Hsieh, J.T. Cancer Res. 2005 65 9906-9913

• Dr. John McConnell Distinguished Chair in Prostate Cancer Research
  (2007)
• Visiting Professor
  Xi?an Jiaotong University (2003)
• Visiting Professor
  The Prostate Center at Vancouver General Hospital (2001)
• SBUR/Merck Young Investigator Award
  (1997)

• American Association for Cancer Research
• American Urological Association
• Phi Tau Phi Scholastic Honor Society
• Society of Basic Urologic Research
• Society of Chinese Bioscientists in America