Featured Publications
Molecular cloning and expression of PPT2, a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity
Soyombo AA, Hofmann SL J. Biol. Chem. 1997 272 27456-63
Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis
Vesa J, Hellsten E, Verkruyse LA, Camp LA, Rapola J, Santavuori P, Hofmann SL, Peltonen L. Nature 1995 376 584-7
Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras
Camp LA, Hofmann SL. J. Biol. Chem. 1993 268 22566-74
Lysosomal metabolism of lipid-modified proteins
Lu, J-Y and Hofmann, SL J. Lipid Res. , in press.
Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice
Virmani, T, Gupta, P, Liu, X, Kavalali, ET and Hofmann, SL Neurobiol. Dis. November 2005 20 314-323
pdf-1, a palmitoyl protein thioesterase 1 ortholog in Schizosaccharomyces pombe: a yeast model of infantile Batten disease
Cho, SK and Hofmann, SL Eukaryot. Cell April 2004 3 302-10
Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features
Gupta, P, Soyombo, AA, Shelton, JM, Wilkofsky, IG, Wisniewski, KE, Richardson, JA and Hofmann, SL Proc. Natl. Acad. Sci. U.S.A. October 2003 100 12325-30
The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (PPT1 and PPT2)
Calero GA, Gupta P, Nonato MC, Tandel S, Biehl ER, Hofmann SL, Clardy J, J. Biol. Chem. September 2003 278 37957-64
