Helen Hobbs, M.D. Professor Endowed Title Dallas Heart Ball Chair in Cardiology Research School Medical School Department Eugene McDermott Center for Human Growth and Development | Internal Medicine | Molecular Genetics Graduate Programs Genetics, Development and Disease You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Download Curriculum Vitae Helen H. Hobbs, M.D., is an Investigator of the Howard Hughes Medical Institute and a Professor of Internal Medicine and Molecular Genetics at the University of Texas Southwestern Medical Center. Dr. Hobbs obtained her undergraduate degree from Stanford University prior to attending Case Western Reserve University School of Medicine. After completing an internship in internal medicine at Columbia-Presbyterian Medical Center, she moved to Dallas, Texas, where she finished her clinical training and served as chief resident in internal medicine at Parkland Memorial Hospital. She worked as a postdoctoral fellow in the laboratory of Drs. Michael Brown and Joseph Goldstein before joining the faculty of UT Southwestern in 1987. She is Director of the McDermott Center for Human Growth and Development, which serves as the Center for Human Genetics at UT Southwestern. She established the Dallas Heart Study, a longitudinal, multiethnic, population-based study of Dallas County, which is now supported by the Hoffman Family Center in Genetics and Epidemiology, and by the National Center for Advancing Translational Science (NCATS). Her work focuses on defining the genetic determinants of plasma lipid levels and cardiovascular risk. Most recently, she has identified genetic variations that confer susceptibility to fatty liver disease. Education Medical School Case Western Reserve University School of Medicine (1979) Internship Columbia Presbyterian Medical Center (1980), Internal Medicine Residency Parkland Health & Hospital System (1983), Internal Medicine Fellowship Parkland Health & Hospital System (1986), Endocrinology & Metabolism Research Interest Genetics and Pathogenesis of fatty liver disease LDL Metabolism Triglyceride trafficking and metabolism Publications Featured Publications Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis. BasuRay S., Wang Y., Smagris E., Cohen J.C., Hobbs H.H. Proc Natl Acad Sci U S A. May 2019 116 1310-1312 HSD17B13 and Chronic Liver Disease in Blacks and Hispanics. Kozlitina J, Stender S, Hobbs HH, Cohen JC N. Engl. J. Med. 2018 11 379 19 1876-1877 Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice. Banfi S, Gusarova V, Gromada J, Cohen JC, Hobbs HH Proc. Natl. Acad. Sci. U.S.A. 2018 Jan Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci. Stender S, Kozlitina J, Nordestgaard BG, Tybjærg-Hansen A, Hobbs HH, Cohen JC Nat. Genet. 2017 Apr Crystal structure of the human sterol transporter ABCG5/ABCG8 Lee J.-Y., Kinch L.N., Borek D.M., Wang J., Wang J., Urbatsch I.L., Xie X.-S., Grishin N.V., Cohen J.C., Otwinowski Z., Hobbs H.H., Rosenbaum D.M. Nature 2016 533 Results 1-5 of 5 1 Honors & Awards Anitschkow Prize (2019) Gerald D. Auerbach Award for Outstanding Translational Research (2019) Honorary Doctor of Humane Letters Degree, Johns Hopkins University (2019) Honorary Doctor of Science Degree, Ichan School of Medicine Mount Sinai (2019) Foundation Lefoulon-Delalande Grand Prix Award (2018) Harrington Prize for Innovation in Medicine (2018) Passano Award (with Jonathan Cohen) (2016) Breakthrough Prize in Life Sciences (2015) Pearl Meister Greengard Prize, Rockefeller University (2015) Pasarow Foundation Award in Cardiovascular Research (2013) International Atherosclerosis Society Prize (2012) American Heart Association Distinguished Scientist Award (2007) National Academy of Sciences, 2007 (2007) American Academy of Arts and Sciences (2006) Heinrich Wieland Prize (2005) Institute of Medicine (2004) The Association of American Physicians (1997) American Society of Clinical Investigation (1991) Professional Associations/Affiliations American Society of Clinical Investigation American Society of Human Genetics Arteriosclerosis, Thrombosis and Vascular Disease Council of the American Heart Association The Association of American Physicians
