Research Interest

  • Dr. Franco has a long-standing interest in epigenetics, gene regulation and non-coding RNAs, particularly how it pertains to cancer. His research program uses genomic, proteomic and molecular approaches to study how endocrine signaling and inflammatory signaling exacerbate hormone-dependent cancers. In addition, Dr. Franco's studies focus on understanding how regulatory information is encoded in the human genome and how genes become deregulated in cancer.


Featured Publications LegendFeatured Publications

Interplay between inflammatory and estrogen signaling in breast cancer.
Nagari A, Franco HL Cytokine 2015 Dec 76 2 588-90
No driver behind the wheel? Targeting transcription in cancer.
Franco HL, Kraus WL Cell 2015 Sep 163 1 28-30
TNFa signaling exposes latent estrogen receptor binding sites to alter the breast cancer cell transcriptome.
Franco HL, Nagari A, Kraus WL Mol. Cell 2015 Apr 58 1 21-34
Nonsense mutations of the bHLH transcription factor TWIST2 found in Setleis Syndrome patients cause dysregulation of periostin.
Franco HL, Casasnovas JJ, Leon RG, Friesel R, Ge Y, Desnick RJ, Cadilla CL Int. J. Biochem. Cell Biol. 2011 Oct 43 10 1523-31
Redundant or separate entities?--roles of Twist1 and Twist2 as molecular switches during gene transcription.
Franco HL, Casasnovas J, Rodríguez-Medina JR, Cadilla CL Nucleic Acids Res. 2011 Mar 39 4 1177-86
Homozygous nonsense mutations in TWIST2 cause Setleis syndrome.
Tukel T, Šošic D, Al-Gazali LI, Erazo M, Casasnovas J, Franco HL, Richardson JA, Olson EN, Cadilla CL, Desnick RJ Am. J. Hum. Genet. 2010 Aug 87 2 289-96

Honors & Awards

  • K99/R00 National Cancer Institute Pathway to Independence Award
    Mechanisms of FoxA1 Latent Enhancer Formation in Response to Proinflammatory Signaling in Hormone Dependent Cancers (2016-2021)
  • American Cancer Society Postdoctoral Fellowship
    Expression and Function of Novel Long Non-Coding RNAs in Breast Cancer (2013-2016)
  • NIH / NIDDK Postdoctoral Support Award for Minorities in Science
    Activity of Nuclear Receptor Coregulators with Chromatin (2012-2013)