Frederick Grinnell (born 1945 in Philadelphia, Pennsylvania) is an American cell biologist, also known for his work in bioethics. Currently, he is Robert McLemore Professor of Medical Science in the department of cell biology at UT Southwestern Medical Center in Dallas, Texas. He took his undergraduate degree in chemistry at Clark University (1966) and Ph.D. in biochemistry at Tufts University (1970). He joined the faculty at UT Southwestern in 1972 and founded the Ethics in Science and Medicine Program and Ethics Grand Rounds in 1998.
Grinnell's early scientific work contributed to the discovery of the biological adhesion protein fibronectin and helped to establish the importance of fibronectin in biomedical engineering and wound repair. Subsequently, his laboratory helped popularize the use of wound fluid to analyze the human wound environment and made the discovery that chronic wounds contain degraded fibronectin and high levels of proteolytic enzymes. In recent years, his research has focused on the use of three dimensional collagen matrices containing fibroblasts to learn about the mechanics of fibrous connective tissue.
In bioethics, Grinnell engages in cross-disciplinary work at the boundary between science and philosophy. His goal is to inform public policy and to advance science education and public understanding of science. Grinnell's work in bioethics is centered in the sociology of knowledge, an approach developed through his studies with the phenomenologists Richard Zaner and Maurice Natanson. He has published two books: The Scientific Attitude, now is in its second edition; and Everyday Practice of Science: Where Intuition and Passion Meet Objectivity and Logic, which was a finalist in the 2010 Royal Society Book Prize competition.
For publications and additional information see the Grinnell website.
|Undergraduate||Clark University (1966)|
|Graduate School||Tufts University (1970), Biochemistry|
- (a) Cell migration and extracellular matrix organization
- (b) Wound repair
- (c) Tumor cell invasiveness
- (d) Tissue engineering and biomaterials
- (e) Research Integrity
- (f) Genetics and bioethics
- (g) Human research ethics
The Scientific Attitude, 2nd Edition
Frederick Grinnell (1992). New York, Guilford Press
Everyday Practice of Science: Where Intuition and Passion Meet Objectivity and Logic
Frederick Grinnell (2009). New York, Oxford University Press
Honors & Awards
- AAAS Fellow, Section on History and Philosophy of Science
- UT System Regents' Outstanding Teaching Award
- Royal Society (UK) Science Book Prize
Shortlist - Everyday Practice of Science (2010)
- Gordon Research Conference on Science and Technology Policy
- UT Southwestern Faculty Senate
- Gordon Research Conference on Wound Repair
- NIH, NIGMS
Merit Award (1999)
- The Hastings Center, Briarcliff Manor, NY
Visiting Fellow (1990)
- Hebrew University, Jerusalem, Israel
Forchheimer Visiting Professor (1988)
- Weizmann Institute, Rehovot, Israel
Meyerhoff Visiting Professor (1984)