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Nick Grishin, Ph.D.

Nick Grishin, Ph.D.

Professor

Endowed Title
Cecil H. and Ida M. Green Chair in Biomedical Science; Virginia Murchison Linthicum Scholar in Biomedical Research
School
Medical School
Department
Biophysics | Biochemistry
Graduate Programs
Molecular Biophysics
  • Biography

    Dr. Grishin is HHMI Investigator and Professor of Biochemistry at UT Southwestern. Born and educated in Russia, he received a Diplom (the Russian equivalent of a master’s degree) in biochemistry from the Moscow State University. His doctoral research in molecular biophysics was done with Margaret Phillips at UT Southwestern. After a postdoctoral year with Eugene Koonin at the National Institutes of Health, he joined the faculty at UT Southwestern.

  • Education
    Graduate School
    Moscow State University - Russ (1993)
    Graduate School
    UT Southwestern Medical Center (1998)
  • Research Interest
    • We study proteins by means of computational methods
  • Publications

    Star Featured Publications

    Featured
    PROMALS: towards accurate multiple sequence alignments of distantly related proteins.
    Pei J, Grishin NV. Bioinformatics January 2007 23(7) 802-808
    Featured
    Protein structure prediction for the male-specific region of the human Y chromosome.
    Ginalski K, Rychlewski L, Baker D, Grishin NV. Proc Natl Acad Sci U S A February 2004 101(8) 2305-2310
    Featured
    COMPASS: a tool for comparison of multiple protein alignments with assessment of statistical significance.
    Sadreyev R, Grishin NV J Mol Biol February 2003 326(1) 317-336
    Featured
    Sequence and structure classification of kinases.
    Cheek S, Zhang H, Grishin NV. J Mol Biol July 2002 320(4) 855-881
    Featured
    Fold change in evolution of protein structures.
    Grishin, N.V. J. Struct. Biol. 2001 134 167-185
    A comprehensive system for evaluation of remote sequence similarity detection
    Qi Y, Sadreyev RI, Wang Y, Kim BH, Grishin NV. BMC Bioinformatics August 2007 8(1) 314
    Searching for three-dimensional secondary structural patterns in proteins with ProSMoS.
    Shi S, Zhong Y, Majumdar I, Sri Krishna S, Grishin NV. Bioinformatics June 2007 23(11) 1331-1338
    COMPASS server for remote homology inference
    Sadreyev RI, Tang M, Kim BH, Grishin NV. Nucleic Acids Res May 2007 35(Web Server issue) W653
    MUMMALS: multiple sequence alignment improved by using hidden Markov models with local structural information.
    Pei J, Grishin NV. Nucleic Acids Res August 2006 34(16) 4364-4374
    Structural classification of small, disulfide-rich protein domains.
    Cheek S, Krishna SS, Grishin NV. J Mol Biol. May 2006 359(1) 215-237
  • Honors & Awards
    • Finn World Travel Award
      to attend 12th Symposium of the Protein Society (1998)
    • UT Southwestern Graduate School
      Nominata Award (1998)
    • Department of Pharmacology
      A.G. Gilman award for excellence in research (1997)
    • GSO Travel Award
      to attend XVII Congress of Intl. Union of Crystallography (1996)