Hao Tang, Ph.D.

Assistant Professor

Department: Department of Clinical Science

Education

Undergraduate (2005), Science
Graduate School University of N C-Chapel Hill (2011), Biochemistry

Research Interests

  • Cancer genetics and Biomarker discovery
  • Cheminformatics tools for Computer-Assisted Drug Design and chemical safety assessments
  • Machine learning
  • Survival analysis and risk prediction

Publications

Featured Publications Legend

Featured Publications

Cytoplasmic TRADD confers a worse prognosis in glioblastoma.

Chakraborty S, Li L, Tang H, Xie Y, Puliyappadamba VT, Raisanen J, Burma S, Boothman DA, Cochran B, Wu J, Habib AA Neoplasia 2013 Aug 15 8 888-97

Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations.

Sato M, Larsen JE, Lee W, Sun H, Shames DS, Dalvi MP, Ramirez RD, Tang H, Dimaio JM, Gao B, Xie Y, Wistuba II, Gazdar AF, Shay JW, Minna JD Mol. Cancer Res. 2013 Feb

A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non-Small-Cell Lung Cancer Patients.

Tang H, Xiao G, Behrens C, Schiller J, Allen J, Chow CW, Suraokar M, Corvalan A, Mao JH, White M, Wistuba II, Minna JD, Xie Y Clin. Cancer Res. 2013 Jan

Do crystal structures obviate the need for theoretical models of GPCRs for structure-based virtual screening?

Tang H, Wang XS, Hsieh JH, Tropsha A Proteins 2012 Jun 80 6 1503-21

Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complex.

Carroll MJ, Gromova AV, Miller KR, Tang H, Wang XS, Tripathy A, Singleton SF, Collins EJ, Lee AL J. Am. Chem. Soc. 2011 Apr 133 16 6422-8

Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity.

Sedykh A, Zhu H, Tang H, Zhang L, Richard A, Rusyn I, Tropsha A Environ. Health Perspect. 2011 Mar 119 3 364-70

Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.

Tang H, Wang XS, Huang XP, Roth BL, Butler KV, Kozikowski AP, Jung M, Tropsha A J Chem Inf Model 2009 Feb 49 2 461-76

Combinatorial QSAR modeling of specificity and subtype selectivity of ligands binding to serotonin receptors 5HT1E and 5HT1F.

Wang XS, Tang H, Golbraikh A, Tropsha A J Chem Inf Model 2008 May 48 5 997-1013

Results 1-8 of 8
  • 1

Honors/Awards

  • First place for NIEHS-NCATS-UNC Dream Toxicogenetics Prediction Challenge 1 and 2
    University of North Carolina (UNC), the National Institutes of Environmental Health Sciences (NIEHS), the National Center for Advancing Translational Sciences (NCATS), and the DREAM project (2013)
  • First place for NCI-Dream Drug Sensitivity Prediction Challenge 2
    National Cancer Institute (NCI) and the DREAM project (2012)
  • CINF-FIZ Scholarship for Scientific Excellence
    The German-American sponsored prize jointly awarded by FIZ CHEMIE and CINF (the Division of Chemical Information of the American Chemical Society) (2010)
  • ADDF Young Investigator Scholarship
    The Alzheimer's Drug Discovery Foundation (2009)
  • Scholarship for Excellent Student
    Tsinghua University, Beijing, China (2001-2004)