Education

Undergraduate
Fudan University (2001), Chemistry
Graduate School
Univ of California-Berkeley (2006), Chemistry

Research Interest

  • Mass Spectrometry
  • Post-translational Modifications (e.g. Phosphorylation and ADP-ribosylation)
  • Quantitative Proteomics
  • Signal Transduction/Cancer Biology and Metabolism

Publications

Featured Publications LegendFeatured Publications

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.
Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J Cell 2017 Nov
A Cell-Line-Specific Atlas of PARP-Mediated Protein Asp/Glu-ADP-Ribosylation in Breast Cancer.
Zhen Y, Zhang Y, Yu Y Cell Rep 2017 Nov 21 8 2326-2337
Genome-wide identification and differential analysis of translational initiation.
Zhang P, He D, Xu Y, Hou J, Pan BF, Wang Y, Liu T, Davis CM, Ehli EA, Tan L, Zhou F, Hu J, Yu Y, Chen X, Nguyen TM, Rosen JM, Hawke DH, Ji Z, Chen Y Nat Commun 2017 Nov 8 1 1749
EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer.
Yamaguchi H, Du Y, Nakai K, Ding M, Chang SS, Hsu JL, Yao J, Wei Y, Nie L, Jiao S, Chang WC, Chen CH, Yu Y, Hortobagyi GN, Hung MC Oncogene 2017 Sep
Global Phosphoproteomic Analysis of Insulin/Akt/mTORC1/S6K Signaling in Rat Hepatocytes.
Zhang Y, Zhang Y, Yu Y J. Proteome Res. 2017 Jul
Quantitative Proteomic Analysis of Optimal Cutting Temperature (OCT) Embedded Core-Needle Biopsy of Lung Cancer.
Zhao X, Huffman KE, Fujimoto J, Canales JR, Girard L, Nie G, Heymach JV, Wistuba II, Minna JD, Yu Y J. Am. Soc. Mass Spectrom. 2017 Jul
Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma.
Eskiocak B, McMillan E, Mendiratta S, Kollipara R, Zhang H, Humphries C, Wang C, Garcia-Rodriguez J, Ding M, Zaman A, Rosales T, Eskiocak U, Smith MP, Sudderth J, Komurov K, DeBerardinis RJ, Wellbrock C, Davies MA, Wargo JA, Yu Y, De Brabander JK, Williams NS, Chin L, Rizos H, Long GV, Kittler R, White M Cancer Discov 2017 Apr
Toxic PRn poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export.
Shi KY, Mori E, Nizami ZF, Lin Y, Kato M, Xiang S, Wu LC, Ding M, Yu Y, Gall JG, McKnight SL Proc. Natl. Acad. Sci. U.S.A. 2017 Jan
PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPß and Modulating Its Transcriptional Activity.
Luo X, Ryu KW, Kim DS, Nandu T, Medina CJ, Gupte R, Gibson BA, Soccio RE, Yu Y, Gupta RK, Kraus WL Mol. Cell 2017 Jan 65 2 260-271
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.
Gibson BA, Zhang Y, Jiang H, Hussey KM, Shrimp JH, Lin H, Schwede F, Yu Y, Kraus WL Science 2016 Jun

Honors & Awards

  • Developmental Research Program Award
    NCI Lung Cancer SPORE (Specialized Programs of Research Excellence) (2017)
  • Young Investigator Award
    Chinese American Diabetes Association (2017)
  • ACS Research Scholar
    American Cancer Society (2015)
  • CPRIT Scholar in Cancer Research
    Cancer Prevention Research Institute of Texas (2011)
  • University of Texas STARS award
    University of Texas System (2011)
  • Virginia Murchison Linthicum Scholar in Medical Research
    UT Southwestern Medical Center (2011)
  • Tuberous Sclerosis Alliance Postdoctoral Fellowship
    Tuberous Sclerosis Alliance (2008)
  • Chun-Tsung Scholar
    Chun-Tsung Endowment (1999)

Professional Associations/Affiliations

  • American Association for Cancer Research (2013)
  • American Society for Mass Spectrometry (2001)