Robert E. Lenkinski, Ph.D., is Professor of Radiology and Vice Chair of Radiology Research at UT Southwestern. He holds the Charles A. and Elizabeth Ann Sanders Chair in Translational Research, and the Jan and Bob Pickens Distinguished Professorship in Medical Science, in Memory of Jerry Knight Rymer and Annette Brannon Rymer and Mr. and Mrs. W.L. Pickens.
Born in a refugee camp in Germany in 1947, Dr. Lenkinski emigrated with his parents to Toronto, Canada, in 1950. He holds a bachelor’s degree in chemistry from the University of Toronto, and earned his doctorate in chemistry from the University of Houston. He then received advanced training at the Weizmann Institute of Science in Israel through a postdoctoral fellowship program in isotope research.
Before joining the faculty at UT Southwestern in 2011, Dr. Lenkinski served as Professor of Radiology at Harvard Medical School. Earlier academic appointments include Visiting Assistant Professor of Chemistry at the University of Houston, Research Assistant Professor of Psychology and Biophysics at the University of Illinois College of Medicine in Chicago, Assistant Professor of Biochemistry at the University of Alabama in Birmingham, Visiting Assistant Professor of Chemistry at the Weizmann Institute of Science, Associate Professor of Chemistry at the University of Guelph in Canada, and Associate Professor of Radiological Science at the University of Pennsylvania School of Medicine, where he received his first appointment as Professor.
An array of research interests
A major focus of Dr. Lenkinski’s research involves developing, validating and applying magnetic resonance spectroscopic (MRS) and multinuclear imaging methods for the study of human disease. He wants to understand how the metabolic information derived from these methods can aid in the diagnosis, staging and treatment of a variety of pathologies. Current applications involve brain tumors, breast cancer, prostate cancer and renal function.
Dr. Lenkinski is also investigating targeted molecular imaging agents, including lanthanide based MRI relaxation and shift reagents and their conjugation to low-molecular weight ligands and their analogous PET tracers. He wants to develop targeted agents for imaging of micro-calcifications in human breast cancer.
Additional research involves the development and validation of a number of quantitative MRI methods, including arterial spin labeling, dynamic contrast enhanced MRI, and diffusion weighted MRI, for the study of human disease.
A career characterized by innovation
As one of the four co-inventors of the endorectal coil for MR imaging of prostate disease, Dr. Lenkinski has seen it become the standard of care in prostate MR throughout the world. Other career accomplishments include building a multicoil array for MR imaging of breast cancer to improve the diagnostic accuracy of lesion characterization; implementing dynamic contrast enhanced MRI of the prostate to improve staging and detection of prostate cancer; demonstrating the potential for correlating genetic expression profiles with phenotypes of human prostate cancer; developing multimodality, targeted contrast agents for imaging malignant micro-calcifications in human breast cancer; establishing an interdisciplinary carbon-13 hyper-polarization NMR program for “pathway specific” metabolic imaging in oncology; launching an MRI program to characterize suspicious lung nodules; and initiating a multimodality (PET/MRI) preclinical imaging program.
Dr. Lenkinski is an active member of multiple professional societies, including the International Society of Magnetic Resonance in Medicine, Radiological Society of North America, American Association for the Advancement of Science, and Alpha Chi Sigma.
In addition to more than 210 original research articles, Dr. Lenkinski has contributed to 15 textbooks and serves as an editor for Academic Radiology and the Journal of Magnetic Resonance Imaging, and as a reviewer for Radiology and Magnetic Resonance in Medicine.
Dr. Lenkinski enjoys playing golf, reading, listening to classical and contemporary music, and spending time with his family.
- University of Toronto - Canada (1968), Chemistry
- Graduate School
- University of Houston-System A (1973), Chemistry
- Related Publications by Dr. Lenkinski
- Clinical applications of in vivo magnetic resonance imaging and spectroscopy
- In vivo multinuclear MR imaging methods, primarily Na-23
- Novel MR and optical based imaging contrast agents in molecular imaging
- High-resolution computed tomography of single breast cancer microcalcifications in vivo.
- Inoue K, Liu F, Hoppin J, Lunsford EP, Lackas C, Hesterman J, Lenkinski RE, Fujii H, Frangioni JV Mol Imaging 2011 Aug 10 4 295-304
- Accurate prostate volume estimation using multifeature active shape models on T2-weighted MRI.
- Toth R, Bloch BN, Genega EM, Rofsky NM, Lenkinski RE, Rosen MA, Kalyanpur A, Pungavkar S, Madabhushi A Acad Radiol 2011 Jun 18 6 745-54
- Impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing pulmonary dynamic contrast-enhanced MR imaging.
- Tokuda J, Mamata H, Gill RR, Hata N, Kikinis R, Padera RF, Lenkinski RE, Sugarbaker DJ, Hatabu H J Magn Reson Imaging 2011 Apr 33 4 968-73
- Perfusion imaging with a freely diffusible hyperpolarized contrast agent.
- Grant AK, Vinogradov E, Wang X, Lenkinski RE, Alsop DC Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2011 Mar 746-55
- Determining histology-MRI slice correspondences for defining MRI-based disease signatures of prostate cancer.
- Xiao G, Bloch BN, Chappelow J, Genega EM, Rofsky NM, Lenkinski RE, Tomaszewski J, Feldman MD, Rosen M, Madabhushi A Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society 2011 Jan 568-78
- CEST and PARACEST MR contrast agents.
- Hancu I, Dixon WT, Woods M, Vinogradov E, Sherry AD, Lenkinski RE Acta Radiol 2010 Oct 51 8 910-23
- A dose- and time-controllable syngeneic animal model of breast cancer microcalcification.
- Liu F, Misra P, Lunsford EP, Vannah JT, Liu Y, Lenkinski RE, Frangioni JV Breast Cancer Res. Treat. 2010 Jul 122 1 87-94
- Principal component analysis of dynamic contrast enhanced MRI in human prostate cancer.
- Eyal E, Bloch BN, Rofsky NM, Furman-Haran E, Genega EM, Lenkinski RE, Degani H Invest Radiol 2010 Apr 45 4 174-81
- A concentration-independent method to measure exchange rates in PARACEST agents.
- Dixon WT, Ren J, Lubag AJ, Ratnakar J, Vinogradov E, Hancu I, Lenkinski RE, Sherry AD Magn Reson Med 2010 Mar 63 3 625-32
- A multislice gradient echo pulse sequence for CEST imaging.
- Dixon WT, Hancu I, Ratnakar SJ, Sherry AD, Lenkinski RE, Alsop DC Magn Reson Med 2010 Jan 63 1 253-6
Honors & Awards
- CPRIT Cancer Scholar in Residence
Missing Link Award (2011)
- Luigi Mastroianni Clinical Innovator Award, School of Medicine, University of Pennsylvania
Award for the construction of the endo-rectal MR coil for prostate imaging (1999)
International Society of Magnetic Resonance in Medicine (1997)
- Member Sigma Xi
Honorary Scientific Organization (1971)
- Alpha Chi Sigma
- American Association for the Advancement of Science
- International Society of Magnetic Resonance in Medicine
- Radiological Society of North America