Biography

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Dr. Malter joined the UTSW faculty as Professor and Chairman of the Department of Pathology in August, 2011. He holds the Senator Betty and Dr. Andy Andujar Distinguished Chair in Pathology. A graduate of Dartmouth College and Washington University School of Medicine in St. Louis, he completed a post-doc and residency training in pathology and laboratory medicine at the University of Pennsylvania. In 1991, he joined the Department of Pathology and Laboratory Medicine at the University of Wisconsin School of Medicine and Public Health. He was Medical Director of the Blood Bank and Transfusion Service (1991-2011) and Molecular Diagnostics Laboratory (2002-2008) for UW Hospital and served as Acting Chair of the Department of Pathology (1993-95). In 2002, Dr. Malter was named an Investigator at the Waisman Center for Developmental Disabilities, UW-Graduate School and became the Cell and Molecular Neuroscience Core Director in 2003 and Associate Director for Biological Sciences in 2004. His research has been continuously funded by the National Institutes of Health and other agencies since 1988 and is currently supported by multiple individual as well as program project grants for his scientific work in post-transcriptional gene regulation and signaling in the immune and nervous systems. He is a member of both the American Society for Investigative Pathology and the American Society for Clinical Investigation, past Chair of several NIH review panels and current member of the editorial boards of Journal of Experimental Medicine and Science Signaling.

Education

Medical School
Washington University School of Medicine (1983)
Residency
University of Pennsylvania School of Medicine (1988), Pathology/lab Medicine

Publications

Featured Publications LegendFeatured Publications

Human eosinophil activin A synthesis and mRNA stabilization are induced by the combination of IL-3 plus TNF.
Kelly EA, Esnault S, Johnson SH, Ying Liu L, Malter JS, Burnham ME, Jarjour NN Immunol. Cell Biol. 2016 Mar
Pin1 regulates axonal growth cone adhesion and spreading through MARCKS isomerization.
Sosa LJ, Malter JS, Hu J, Bustos Plonka F, Oksdath M, Nieto Guil A, Quiroga S, Pfenninger KH J. Neurochem. 2016 Mar
Phosphate-Induced Renal Fibrosis Requires the Prolyl Isomerase Pin1.
Shen ZJ, Hu J, Shiizaki K, Kuro-O M, Malter JS PLoS ONE 2016 11 2 e0150093
The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.
Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS, Hooper LV, Zaki MH Cell Rep 2015 Dec 13 9 1922-36
IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils.
Esnault S, Kelly EA, Shen ZJ, Johansson MW, Malter JS, Jarjour NN J. Immunol. 2015 Aug
XBP1, a determinant of the eosinophil lineage.
Shen ZJ, Malter JS Nat. Immunol. 2015 Jul 16 8 793-4
RNA Seq profiling reveals a novel expression pattern of TGF-ß target genes in human blood eosinophils.
Shen ZJ, Hu J, Esnault S, Dozmorov I, Malter JS Immunol. Lett. 2015 Jun
Determinants of eosinophil survival and apoptotic cell death.
Shen ZJ, Malter JS Apoptosis 2015 Feb 20 2 224-34
Regulation of AU-Rich Element RNA Binding Proteins by Phosphorylation and the Prolyl Isomerase Pin1.
Shen ZJ, Malter JS Biomolecules 2015 5 2 412-434
Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines.
Esnault S, Kelly EA, Johansson MW, Liu LY, Han ST, Akhtar M, Sandbo N, Mosher DF, Denlinger LC, Mathur SK, Malter JS, Jarjour NN Clin. Immunol. 2014 Jan 150 1 90-100

Honors & Awards

  • Member
    American Society for Clinical Investigation (1998)
  • Nominee
    Romnes Fellow, University of Wisconsin, Madison, WI (1993)
  • Outstanding Young Investigator
    Academy of Clinical Laboratory Physicians & Scientists (1987)
  • NIH
    National Research Service Award (1986)
  • Rufus Choate Scholar
    Biochemistry - Dartmouth College (1978)

Professional Associations/Affiliations

  • American Association for the Advancement of Science
  • American Association of Blood Banks
  • American Society for Clinical Investigation
  • American Society for Investigative Pathology
  • American Society of Biochemistry and Molecular Biology