Sean J. Morrison is the director of the Children’s Medical Center Research Institute (CRI) at UT Southwestern, the Mary McDermott Cook Chair in Pediatric Genetics, the Kathryne and Gene Bishop Distinguished Chair in Pediatric Research, and a Howard Hughes Medical Institute investigator.
Dr. Morrison obtained his B.Sc. in biology and chemistry from Dalhousie University (1991), his Ph.D. in immunology at Stanford University (1996) and his postdoctoral fellowship in neurobiology at Caltech (1999). From 1999 to 2011, Dr. Morrison was a professor at the University of Michigan, where he directed their Center for Stem Cell Biology. His laboratory studies the mechanisms that regulate stem cell function in adult tissues and the ways in which those mechanisms get hijacked by cancer cells to enable tumor formation.
Dr. Morrison was a Searle Scholar (2000-2003) and received the Presidential Early Career Award for Scientists and Engineers (2003), the International Society for Hematology and Stem Cell’s McCulloch and Till Award (2007), the American Association of Anatomists Harland Winfield Mossman Award (2008) and a MERIT Award from the National Institute on Aging (2009). He recently served as President of the International Society for Stem Cell Research (2015). Dr. Morrison has also been active in public policy issues surrounding stem cells. He twice testified before Congress and was a leader in the successful “Proposal 2” campaign to protect and regulate stem cell research in Michigan’s state constitution.
The Morrison laboratory studies the mechanisms that maintain stem cell function in adult tissues and the ways in which cancer cells hijack these mechanisms to enable neoplastic proliferation. A better understanding of these mechanisms offers the potential to yield new regenerative medicine and cancer therapies.
- Dalhousie University - Canada (1991), Biology
- Graduate School
- Stanford University (1996)
- Cancer stem cell biology
- Melanoma cell proliferation and metastasis
- Stem cell aging
- Stem cell self-renewal
- Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.
- Agathocleous M, Meacham CE, Burgess RJ, Piskounova E, Zhao Z, Crane GM, Cowin BL, Bruner E, Murphy MM, Chen W, Spangrude GJ, Hu Z, DeBerardinis RJ, Morrison SJ Nature 2017 Aug
- Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton.
- Yue R, Shen B, Morrison SJ Elife 2016 Dec 5
- A perisinusoidal niche for extramedullary haematopoiesis in the spleen.
- Inra CN, Zhou BO, Acar M, Murphy MM, Richardson J, Zhao Z, Morrison SJ Nature 2015 Nov 527 7579 466-71
- Oxidative stress inhibits distant metastasis by human melanoma cells.
- Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ Nature 2015 Oct
- Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal.
- Acar M, Kocherlakota KS, Murphy MM, Peyer JG, Oguro H, Inra CN, Jaiyeola C, Zhao Z, Luby-Phelps K, Morrison SJ Nature 2015 Sep
- Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow.
- Zhou BO, Yue R, Murphy MM, Peyer JG, Morrison SJ Cell Stem Cell 2014 Jun
- Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain.
- Mich JK, Signer RA, Nakada D, Pineda A, Burgess RJ, Vue TY, Johnson JE, Morrison SJ Elife 2014 May e02669
- Haematopoietic stem cells require a highly regulated protein synthesis rate.
- Signer RA, Magee JA, Salic A, Morrison SJ Nature 2014 Mar
- Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.
- Nakada D, Oguro H, Levi BP, Ryan N, Kitano A, Saitoh Y, Takeichi M, Wendt GR, Morrison SJ Nature 2014 Jan 505 7484 555-8
- The bone marrow niche for haematopoietic stem cells.
- Morrison SJ, Scadden DT Nature 2014 Jan 505 7483 327-34
Honors & Awards
- CPRIT Scholar in Cancer Research
- MERIT Award, National Institute on Aging
- Harland Winfield Mossman Award, American Association of Anatomists
- McCulloch and Till Award, International Society for Hematology & Stem Cells
- Presidential Early Career Award for Scientists and Engineers, White House Office of Science and Technology
- President, International Society for Stem Cell Research (2015-2016)
- Senior Editor, eLife (2014)
- Investigator, Howard Hughes Medical Institute (2000)