Education

Medical School
Duke University (1988)
Residency
Wilford Hall Medical Center (1991), Pediatrics
Fellowship
Dana-Farber Cancer Institute (1994), Pediatric Hematology/oncology

Specialty Areas

Clinical Interest

  • Childhood Blood Disease
  • Childhood Cancer
  • Rhabdomyosarcoma
  • Research Interest

    • Elucidating molecular mechanisms for Arf-dependent regulation of vascular involution during eye development and tumor angiogenesis.
    • Studying the molecular basis for how persistent expression of cyclin D1 in mouse photoreceptors and pinealocytes disrupts normal eye development and leads to tumor formation as a novel model for retinoblastoma and pineoblastoma.
    • Treatment of children with aggressive fibromatosis using minimally-toxic therapy.
    • Understanding molecular and genetic mechanisms for coordinating the initiation of differentiation with cell proliferation arrest in skeletal myoblasts and determining whether the manipulation of these programs alters the biology of rhabdomyosarcoma-derived cells.

    Publications

    Featured Publications LegendFeatured Publications

    The Role of Childhood Infections and Immunizations on Childhood Rhabdomyosarcoma: A Report From the Children's Oncology Group.
    Sankaran H, Danysh HE, Scheurer ME, Okcu MF, Skapek SX, Hawkins DS, Spector LG, Erhardt EB, Grufferman S, Lupo PJ Pediatr Blood Cancer 2016 May
    Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop.
    Hingorani P, Janeway K, Crompton BD, Kadoch C, Mackall CL, Khan J, Shern JF, Schiffman J, Mirabello L, Savage SA, Ladanyi M, Meltzer P, Bult CJ, Adamson PC, Lupo PJ, Mody R, DuBois SG, Parsons DW, Khanna C, Lau C, Hawkins DS, Randall RL, Smith M, Sorensen PH, Plon SE, Skapek SX, Lessnick S, Gorlick R, Reed DR Cancer Genet 2016 May 209 5 182-94
    Histology, Fusion Status, and Outcome in Alveolar Rhabdomyosarcoma With Low-Risk Clinical Features: A Report From the Children's Oncology Group.
    Arnold MA, Anderson JR, Gastier-Foster JM, Barr FG, Skapek SX, Hawkins DS, Raney RB, Parham DM, Teot LA, Rudzinski ER, Walterhouse DO Pediatr Blood Cancer 2016 Jan
    p19(Arf) limits primary vitreous cell proliferation driven by PDGF-B.
    Iqbal NS, Devitt CC, Sung CY, Skapek SX Exp. Eye Res. 2016 Jan 145 224-229
    Negative regulation of initial steps in skeletal myogenesis by mTOR and other kinases.
    Wilson RA, Liu J, Xu L, Annis J, Helmig S, Moore G, Timmerman C, Grandori C, Zheng Y, Skapek SX Sci Rep 2016 6 20376
    Clinical Application of Prognostic Gene Expression Signature in Fusion Gene-Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group.
    Hingorani P, Missiaglia E, Shipley J, Anderson JR, Triche TJ, Delorenzi M, Gastier-Foster J, Wing M, Hawkins DS, Skapek SX Clin. Cancer Res. 2015 Oct 21 20 4733-9
    The World Health Organization Classification of Skeletal Muscle Tumors in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group.
    Rudzinski ER, Anderson JR, Hawkins DS, Skapek SX, Parham DM, Teot LA Arch. Pathol. Lab. Med. 2015 May
    Family history of cancer and childhood rhabdomyosarcoma: a report from the Children's Oncology Group and the Utah Population Database.
    Lupo PJ, Danysh HE, Plon SE, Curtin K, Malkin D, Hettmer S, Hawkins DS, Skapek SX, Spector LG, Papworth K, Melin B, Erhardt EB, Grufferman S, Schiffman JD Cancer Med 2015 Mar
    Clonality and evolutionary history of rhabdomyosarcoma.
    Chen L, Shern JF, Wei JS, Yohe ME, Song YK, Hurd L, Liao H, Catchpoole D, Skapek SX, Barr FG, Hawkins DS, Khan J PLoS Genet. 2015 Mar 11 3 e1005075
    Sarcomas.
    HaDuong JH, Martin AA, Skapek SX, Mascarenhas L Pediatr. Clin. North Am. 2015 Feb 62 1 179-200

    Books

    Featured Books Legend Featured Books

    Honors & Awards

    • Best Pediatric Specialists in Dallas
      D Magazine (2015)
    • Distinguished Professorship in Pediatric Oncology Research
      Children’s Cancer Fund (2011)
    • Research Scholar Award
      American Cancer Society (2004)
    • Medical Research Award
      G and P Foundation for Cancer Research (1999)
    • Clinical Investigator Development Award (K08)
      NIH (1994)
    • Achievement Medal
      United States Air Force (1992)

    Professional Associations/Affiliations

    • American Association for Cancer Research (2008)
    • American Society of Pediatric Hematology/Oncology (2008)
    • Association for Research in Vision and Ophthalmology (2006)
    • Intergroup Rhabdomyosarcoma Study Group (1999-2000)
    • Pediatric Oncology Group/Children's Oncology Group (1997)