Dr. Alfred G. Gilman was born in New Haven, Connecticut in 1941. He received his B.S. (summa cum laude) in Biochemistry in 1962 from Yale University, and his M.D. and Ph.D. in Pharmacology in 1969 from Case Western Reserve University. He completed his postdoctoral training in the Laboratory of Biochemical Genetics at the National Institutes of Health (1969-71). In 1971 Dr. Gilman began a ten-year stay at the University of Virginia in Charlottesville. His positions in the Dept. Of Pharmacology included Assistant Professor (1971-73), Associate Professor (1973-77), and Professor (1977-81). In addition he was Director of the Medical Scientist Training Program (1978-81). Dr. Gilman became Chairman of the Department of Pharmacology at the University of Texas Southwestern Medical Center at Dallas in 1981. He was named a Regental Professor in 1995. Dr. Gilman discovered, characterized, and purified a set of guanine nucleotide-binding regulatory proteins termed G proteins. His observations provided for the first time a firm molecular basis for understanding certain signal transduction processes present throughout nature. He was also the primary editor (in 1980, 1985, and 1990) of the best known textbook of Pharmacology, Goodman and Gilman's The Pharmacological Basis of Therapeutics. In 2004, Dr. Gilman was named Dean of Southwestern Medical School. In addition, in 2006 he became Executive Vice President for Academic Affairs and Provost of the University of Texas Southwestern Medical Center. Gilman retired from UT Southwestern in 2009 to assume the position of Chief Scientific Officer of the Cancer Prevention and Research Institute of Texas (CPRIT), a position he held until 2012. Email him at AGGilman@gmail.com.
|Medical School||Case Western Reserve University (1969)|
|Graduate School||Case Western Reserve University (1969)|
- Adenylyl Cyclases
- Cellular Signaling
- G Proteins
- RGS Proteins
- Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gs∀AGTP(S.
- Tesmer, J.J.G., Sunahara, R.K., Gilman, A.G., and Sprang, S.R. Science 1997 278 1907-1916
- Inhibition of adenylyl cyclase by Gi∀
- Taussig, R., Iniguez-Lluhi, J. A., and Gilman, A. G. Science 1993 261 218-221
- Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure.
- Krupinski, J., Coussen, F., Bakalyar, H. A., Tang, W.-J., Feinstein, P. G., Orth, K., Slaughter, C., Reed, R. R., and Gilman, A. G. Science 1989 244 1558-1564
- Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase
- Bokoch, G.M., Katada, T., Northup, J.K., Ui, M., and Gilman, A.G. J. Biol. Chem. 1984 259 3560-3567 See also pp. 3568-3395.
- Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme.
- Ross, E.M., Howlett, A.C., Ferguson, K.M., and Gilman, A.G. J. Biol. Chem. 1978 253 6401-6412
Honors & Awards
- Doctor of Medical (Hon.), Yale University
- Nobel Prize in Physiology or Medicine
- Albert Lasker Basic Medical Research Award
- Member, National Academy of Sciences