Southern Methodist University (1966)
Graduate School
University of Oklahoma Norman (1967)
Graduate School
University of Oklahoma-Hlth Sc (1972), Neuroscience

Research Interest

  • Blood biomarkers are being sought for Parkinson's disease, Alzheimer's disease and autism. Blood samples from patients with these diseases are analyzed to identify potential antibody and protein biomarkers that can be used to diagnose the diseases, and possibly identify the diseases before symptoms occur.
  • Environmental links to neurodegenerative disease: role of pesticides. Pesticide exposure (e.g., Lindane and DDT) may be responsible for some cases of Parkinson's disease and Alzheimer's disease.
  • Parkinson's disease and Alzheimer's disease are studied to understand the mechanisms responsible for neurodegeneration. Blood and brain tissue from patients and animal models of these diseases are used.


Featured Publications LegendFeatured Publications

A search for blood biomarkers for autism: peptoids.
Zaman S, Yazdani U, Deng Y, Li W, Gadad B, Hynan, L, Karp D, Roatch N, Schutte C, Marti CN, Hewitson L, German DC. 2016
Administration of thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology.
Gadad B, Li W, Yazdani U, Grady S, Johnson T, Hammond J, Gunn H, Curtis B, English C, Yutuc V, Ferrier C, Sackett G, Marti N, Young KA, Hewitson L, German DC. 2015
The NINDS Parkinson?s disease biomarker program.
Rosenthal LS, Drake D, Alcalay R, Babcock D, Bowman FD, Chen-Plotkin A, Dawson TM, Dewey RB, German DC, Huang X, Landin B, McAuliffe M, Petyuk V, Scherzer CR, St. Hillaire-Clarke C, Sieber B-A, Sutherland M, Tarn C, West A, Vaillancourt D, Zhang J, Zhang R, Gwinn K, on behalf of the PDBP consortium 2015
Klotho protects dopaminergic neurons in vivo via ASK1 and p38 MAPK signaling pathways.
Brobey RK, German D, Sonsalla PK, Gurmani P, Pastor J, Papaconstantinou J, Foster PP, Kuro-o M, Rosenblatt KP. 2015
Validation of a serum screen for Alzheimer's disease across assay platforms, species and tissue.
O'Bryant SE, Xiao G, Zhang F, Edwards ML, German DC, Yin X, Como T, Reisch J, Huebinger HM, Graff-Radford N, Dickson D, Barber RC, Hall J, O?Suilleabhain P, Grammas P. 2014
Neuropathology and animal models of autism: genetic and environmental factors.
Gadad BS, Hewitson L, Young KA, German DC. 2013
Apoptosis signal-regulating kinase 1 mediates MPTP toxicity and regulates glial activation.
Lee K-W, Zhao X, Im J-Y, Grosso H, Jang WH, Chan TW, Sonsalla PK, German DC, Ichijo H, Junn E, Mouradian MM. 2012
Beta-hexachlorocyclohexane levels in serum and risk of Parkinson's disease.
Richardson JR, Roy A, Shalat SL, Buckley B, Winnik B, Gearing M, Levey AI, Factor SA, O?Suilleabhain P, German DC. 2011

Honors & Awards

  • Grant Reviewer for New Jersey Governor¬ís Council for Medical Research and Treatment of Autism
  • Nominator for Kyoto Prize
  • Grant Review Committee, Alzheimer's Association
  • Editorial Board, Current Molecular Pharmacology

Professional Associations/Affiliations

  • American Association for the Advancement of Science
  • Society for Neuroscience