Adi Gazdar, M.D. - Faculty Profile

Biography

Guy's Hospital Medical School M.B., B.S. 1961 Medicine University of London , London UK A. Positions and Honors. 1964-1966 Resident in Pathology, Peter Bent Brigham Hospital, Boston, MA 1966-1967 Resident in Pathology, New England Deaconess Hospital, Boston, MA 1967-1968 Resident in Pathology, Peter Bent Brigham Hospital, Boston, MA 1968-1969 Medical Officer, Pathology, National Cancer Institute, Bethesda, MD 1969-1975 Head, Viral Pathology Section, NCI 1975-1981 Head, Human Tumor Cell Biology Laboratory, Senior Investigator and Pathologist, NCI VA Medical Oncology Branch, NCI, and Veterans Medical Center, Washington, D.C.. 1981-1991 Head, Human Tumor Cell Biology Section, Senior Investigator and Pathologist, NCI-Navy Oncology Branch, NCI, Bethesda, MD. 1991-Pres Professor, Department of Pathology and Simmons Cancer Center, UT Southwestern Medical Center at Dallas, Dallas, TX. 1997-Pres Deputy Head, Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center at Dallas, Dallas, TX. Honors Dr. Gazdar is the holder of the W. Ray Wallace Distinguished Chair in Molecular Pathology Research. The Institute for Scientifc Information includes Dr. Gazdar in a list of the world's most cited authors--comprising less than one half of one percent of all publishing researchers, based on the important scientific developments of the last two decades. B. Selected peer-reviewed publications (in chronological order). Publications (selected from more than 500) 1. Gazdar, A. F. and Czerniak, B. Filling the void: urinary markers for bladder cancer risk and diagnosis. J Natl Cancer Inst, 93: 413-415., 2001. 2. Gazdar, A. F. and Minna, J. D. Angiogenesis and the multistage development of lung cancers [editorial]. Clin Cancer Res, 6: 1611-1612, 2000. 3. Gazdar, A. F. and Minna, J. D. Targeted therapies for killing tumor cells. Proc Natl Acad Sci U S A, 98: 10028-10030., 2001. 4. Harada, K., Toyooka, S., Maitra, A., Maruyama, R., Toyooka, K. O., Timmons, C. F., Tomlinson, G. E., Mastrangelo, D., Hay, R. J., Minna1, J. D., and Gazdar, A. F. Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines. Oncogene, in press, 2002. 5. Hirsch, F. R., Franklin, W. A., Gazdar, A. F., and Bunn, P. A., Jr. Early detection of lung cancer: clinical perspectives of recent advances in biology and radiology. Clin Cancer Res, 7: 5-22., 2001. 6. Jasani, B., Cristaudo, A., Emri, S. A., Gazdar, A. F., Gibbs, A., Krynska, B., Miller, C., Mutti, L., Radu, C., Tognon, M., and Procopio, A. Association of SV40 with human tumours. Semin Cancer Biol, 11: 49-61., 2001. 7. Maitra, A. and Gazdar, A. F. Tissue microdissection and processing. Cancer Treat Res, 106: 63-84, 2001. 8. Maitra, A., Wistuba, II, Washington, C., Virmani, A. K., Ashfaq, R., Milchgrub, S., Gazdar, A. F., and Minna, J. D. High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss. Am J Pathol, 159: 119-130, 2001. 9. Maruyama, R., Toyooka, S., Toyooka, K. O., Harada, K., Virmani, A. K., Zochbauer-Muller, S., Farinas, A. J., Vakar-Lopez, F., Minna, J. D., Sagalowsky, A., Czerniak, B., and Gazdar, A. F. Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features. Cancer Res, 61: 8659-8663, 2001. 10. Maruyama, R., Toyooka, S., Toyooka, K. O., Virmani, A. K., Zochbauer-Muller, S., Farinas, A. J., Minna, J. D., McConnell, J., Frenkel, E. P., and Gazdar, A. F. Aberrant Promoter Methylation Profile of Prostate Cancers and Its Relationship to Clinicopathological Features. Clin Cancer Res, 8: 514-519, 2002. 11. Miura, N., Onuki, N., Rathi, A., Virmani, A., Nakamoto, S., Kishimoto, Y., Murawaki, Y., Kawasaki, H., Hasegawa, J., Oshimura, M., Travis, W. D., and Gazdar, A. F. hTR repressor-related gene on human chromosome 10p15.1. Br J Cancer, 85: 1510-1514, 2001. 12

Education

Medical School

Guy's Hospital Medical School - England (1961)

Research Interests

Methylation induced inactivation of tumor suppressor genes
Methylation induced inactivation of tumor suppressor genes
Molecular pathogenesis of human cancers espcially lung cancers
Molecular pathogenesis of human cancers espcially lung cancers
Preneoplastic changes preceding cancer
Preneoplastic changes preceding cancer
Role of SV40 virus in pathogenesis of human cancers
Role of SV40 virus in pathogenesis of human cancers

Publications

Featured Publications

Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers.

Shigematsu, N. and Gazdar, A.F. Int J Cancer 2006 118 257-262

Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers.

Shigematsu, N. and Gazdar, A.F. Int J Cancer 2006 118 257-262

Inhibition of ECFR Signaling: All Mutations Are Not Created Equal.

Gazdar, A.F. and Minna, J.D. PLos Med 2005 2 e377

Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors.

Reddy, J., Shivapurkar, N., Takashashi, T., Parikh, G., Stastny, V., Echebiri, C., Crumrine, K., Zochbauer-Muller, S., Drach, J., Zheng, Y., Feng, Z., Kroft, S.H., McKenna, R.W., and Gazdar, A.F. Oncogene 2005 24 732-736

Genomic alterations in cultured human embryonic stem cells.

Maitra, A., Arking, D.E., Shivapurkar, N., Ikeda, M., Stastny, V., Kassauei, K., Sui, G., Cutler, D.J., Liu, Y., Brimble, S.N., Noaksson, K., Hyllner, J., Schulz, T.C., Zeng, X., Freed, W.J., Crook, J., Abraham, S., Colman, A., Sartipy, P., Matsui, S.I., Carpenter, M., Gazdar, A.F., Rao, M., and Chakravarti, A. Nat Genet 2005 37 1099-1103