Joseph Garcia, Ph.D., M.D.

Dr. Joseph Garcia received his MD,PhD from the University of California, Los Angeles. He completed an Internal Medicine residency and Cardiology fellowship at UT Southwestern Medical Center, followed by a postdoctoral research fellowship in the Department of Biochemistry at UT Southwestern Medical Center. After his training, he joined the Internal Medicine/Cardiology faculty at UT Southwestern Medicai Center. His clinical duties are currently performed at the VA North Texas Health Care System in Dallas. Dr. Garcia's research interests are in the role of stress signaling in mammalian physiology with a particular focus on its relevance in human disease.

Undergraduate	California Institute of Technology (1982), Biology
Medical School	University of California-los Angeles (1993), Medicine
Graduate School	University of California-los Angeles (1993), Microbiology

• Enviromental stress signaling
• HIF biology

Featured Publications

The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.

Chen R, Xu M, Hogg RT, Li J, Little B, Gerard RD, Garcia JA J. Biol. Chem. 2012 Aug 287 36 30800-11

Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner.

Chen R, Dioum EM, Hogg RT, Gerard RD, Garcia JA J. Biol. Chem. 2011 Apr 286 16 13869-78

Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.

Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, Gerard RD, Garcia JA. Science June 2009 324(5932) 1289-93

HIF-2alpha-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery.

Dioum EM, Clarke SL, Ding K, Repa JJ, Garcia JA. Invest Ophthalmol Vis Sci. June 2008 49(6) 2714-20

Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin.

Oktay Y, Dioum E, Matsuzaki S, Ding K, Yan LJ, Haller RG, Szweda LI, Garcia JA. Journal of Biological Chemistry April 2007 282(16) 11750-6

Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha.

Ding K, Scortegagna M, Seaman R, Birch DG, Garcia JA. Invest Ophthalmol Vis Sci. March 2005 46(3) 1010-6

HIF-2{alpha} regulates murine hematopoietic development in an erythropoietin-dependent manner.

Scortegagna M, Ding K, Zhang Q, Oktay Y, Bennett MJ, Bennett M, Shelton JM, Richardson JA, Moe O, Garcia JA. Blood December 2004 105/8 3133-40

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice.

Scortegagna M, Ding K, Oktay Y, Gaur A, Thurmond F, Yan LJ, Marck BT, Matsumoto AM, Shelton JM, Richardson JA, Bennett MJ, Garcia JA. Nature Genetics December 2003 35/4 331-40

The HIF family member EPAS1/HIF-2alpha is required for normal hematopoiesis in mice.

Scortegagna M, Morris MA, Oktay Y, Bennett M, Garcia JA Blood 2003 Sep 102 5 1634-40

Allosteric inhibition of hypoxia inducible factor-2 with small molecules.

Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK Nat. Chem. Biol. 2013 Feb