Christine Garcia, M.D., Ph.D.

Christine Kim Garcia, MD, PhD is an Associate Professor of Internal Medicine and a member of the Eugene McDermott Center for Human Genetics at the University of Texas Southwestern Medical Center. She obtained her BS undergraduate degree in Chemistry from Texas A&M University and a combined MD/PhD degree from UT Southwestern, where she completed her graduate training in the laboratory of Drs. Michael Brown and Joseph Goldstein. She worked as a postdoctoral fellow in the laboratory of Dr. Helen Hobbs in Molecular Genetics before joining the faculty of UT Southwestern in 2005. Her laboratory focuses on defining the genetic determinants of adult-onset pulmonary disease. She is a member of the American Society for Clinical Investigation.

University	Texas A&M University (1988)
University	University of Texas Southwestern (1996)
Medical School	University of Texas Southwestern Medical Center (1996)
Residency	University of Texas Southwestern (2001), Internal Medicine
Fellowship	University of Texas Southwestern (2004), Pulmonary Disease & Critical Care Medicine
Fellowship	University of Texas Southwestern (2006), Research

• General Pulmonology
• Interstitial Lung Disease

• Primary Interests
• Asbestosis (ILD)
• Berylliosis (ILD)
• Birt-Hogg-Dube Syndrome
• Bronchiolitis Obliterans (ILD)
• Bronchiolitis Obliterans Organizing Pneumonia (BOOP) (ILD)
• Connective Tissue Disease (ILD)
• Cryptogenic Organzing Pneumonia
• Desquamative Interstitial Pneumonia (ILD)
• Drug Induced Lung Disease (ILD)
• Dykeratosis Congenita with Lung Disease
• Familial Pulmonary Alveolar Microlithiasis
• Familial Pulmonary Fibrosis
• Familial Spontaneous Pneumothorax
• Hermasky-Pudlak Syndrome with Lung Disease
• Hyper IgE Syndrome with Lung Disease
• Hypersensitivity Pneumonia (ILD)
• Idiopathic Fibrosing Alveolitis (ILD)
• Idiopathic Pulmonary Fibrosis (IPF) (ILD)
• Inflammatory Myopathy (MDA)
• Interstitial Lung Disease (ILD)
• Interstitial Pneumonitis
• Lupus - Pulmonary Complications
• Lymphangioleiomyomatosis (LAM) (ILD)
• Lymphocytic Interstitial Pneumonia (ILD)
• Organizing Pneumonia (ILD)
• Pneumoconiosis (ILD)
• Post Inflammatory Pulmonary Fibrosis (ILD)
• Pulmonary Fibrosis - Interstitial Lung Disease (ILD)
• Pulmonary Vasculitis (ILD)
• Relapsing Polychondritis (ILD)
• Respiratory Bronchiolitis with ILD
• Rheumatoid Arthritis -Pulmonary Complications (ILD)
• Scleroderma - Pulmonary Complications (ILD)
• Silicosis (ILD)
• Sjogren's Disease - Pulmonary Complications (ILD)
• Surfactant Metabolism Dysfunction
• Systemic Lupus Erythematosus - Pulmonary Complications (ILD)
• Telomerase Dysfunction
• Tuberous Sclerosis Complex with Lung Disease
• Vasculitis
• Wegener's Granulomatosis (ILD)

• Genetic determinants of adult lung disease
• Mouse models of lung fibrosis and cancer
• Telomerase dysfunction in pulmonary fibrosis

Featured Publications

Idiopathic pulmonary fibrosis: update on genetic discoveries.

Garcia CK Proc Am Thorac Soc 2011 May 8 2 158-62

Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer.

Wang Y, Kuan PJ, Xing C, Cronkhite JT, Torres F, Rosenblatt RL, DiMaio JM, Kinch LN, Grishin NV, Garcia CK Am. J. Hum. Genet. 2009 Jan 84 1 52-9

Adult-onset pulmonary fibrosis caused by mutations in telomerase.

Tsakiri KD, Cronkhite JT, Kuan PJ, Xing C, Raghu G, Weissler JC, Rosenblatt RL, Shay JW, Garcia CK Proc. Natl. Acad. Sci. U.S.A. 2007 May 104 18 7552-7

Subclinical Lung Disease, Macrocytosis and Premature Graying in Kindreds with Telomerase (TERT) Mutations.

Diaz de Leon A, Cronkhite JT, Yilmaz C, Brewington C, Wang R, Xing C, Hsia CC, Garcia CK Chest 2011 Feb 753-63

Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress.

Maitra M, Wang Y, Gerard RD, Mendelson CR, Garcia CK J. Biol. Chem. 2010 Jul 285 29 22103-13

Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations.

Diaz de Leon A, Cronkhite JT, Katzenstein AL, Godwin JD, Raghu G, Glazer CS, Rosenblatt RL, Girod CE, Garrity ER, Xing C, Garcia CK PLoS ONE 2010 5 5 e10680

Telomere shortening in familial and sporadic pulmonary fibrosis.

Cronkhite JT, Xing C, Raghu G, Chin KM, Torres F, Rosenblatt RL, Garcia CK Am. J. Respir. Crit. Care Med. 2008 Oct 178 7 729-37

Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults.

Graham RB, Nolasco M, Peterlin B, Garcia CK Am. J. Respir. Crit. Care Med. 2005 Jul 172 1 39-44

Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein.

Garcia CK, Wilund K, Arca M, Zuliani G, Fellin R, Maioli M, Calandra S, Bertolini S, Cossu F, Grishin N, Barnes R, Cohen JC, Hobbs HH Science 2001 May 292 5520 1394-8

Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle.

Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS Cell 1994 Mar 76 5 865-73

Featured Books

Genetic Interstitial Lung Disease. In Clinics in Chest Medicine:

Garcia CK and Raghu G (2012). Elsevier, Inc.

• American Society for Clinical Investigation
  (2012)
• Doris Duke Charitable Foundation Clinical Scientist Development Award
  (2008)
• President's Research Council Young Investigator Award
  (2006)
• Charles E. Culpeper Medical Scholar
  (2004)
• Parker B. Francis Fellowship
  (2003)
• Alpha Omega Alpha
  (1991)

• American Society for Clinical Investigation (2012)
• American Thoracic Society (2007)
• American Society of Human Genetics (2006)