Christine Garcia, M.D., Ph.D.

Associate Professor

Endowed Title: Kern and Marnie Wildenthal President's Research Council Professorship in Medical Science

Department: Eugene McDermott Center for Human Growth & Development, Internal Medicine

Graduate Programs: Genetics and Development, Integrative Biology

Biography

Christine Kim Garcia, MD, PhD is an Associate Professor of Internal Medicine and a member of the Eugene McDermott Center for Human Genetics at the University of Texas Southwestern Medical Center. She obtained her BS undergraduate degree in Chemistry from Texas A&M University and a combined MD/PhD degree from UT Southwestern, where she completed her graduate training in the laboratory of Drs. Michael Brown and Joseph Goldstein. She worked as a postdoctoral fellow in the laboratory of Dr. Helen Hobbs in Molecular Genetics before joining the faculty of UT Southwestern in 2005. She directs an active research laboratory that focuses on defining the genetic determinants and molecular mechanisms of adult-onset pulmonary disease. Her laboratory has discovered four different genes associated with rare forms of inherited lung disease. She is a member of the American Society for Clinical Investigation.

Education

University Texas A&M University (1988)
Medical School UT Southwestern Medical Center (1996)
Medical School UT Southwestern Medical Center (1996)
Residency UT Southwestern Medical Center (2001), Internal Medicine
Fellowship UT Southwestern Medical Center (2004), Pulmonary Diseases & Critical Care Medicine
Fellowship UT Southwestern Medical Center (2006), Research

Specialty Areas

Clinical Interests

  • Familial Pulmonary Fibrosis
  • Familial Spontaneous Pneumothorax
  • Inherited Lung Disease
  • Interstitial Lung Disease
  • Surfactant Metabolism Dysfunction
  • Telomerase Dysfunction

Research Interests

  • Genetic determinants of adult lung disease
  • Mouse models of lung disease
  • Telomerase dysfunction in pulmonary fibrosis

Publications

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Featured Publications

Lung Fibrosis Associated Surfactant Protein A1 and C Variants Induce Latent TGF-ß1 Secretion in Lung Epithelial Cells.

Maitra M, Dey M, Yuan WC, Nathanielsz PW, Garcia CK J. Biol. Chem. 2013 Aug

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.

Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Cogan JD, Mason WR, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Smith K, McKean D, Pedersen BS, Talbert J, Kidd RN, Markin CR, Beckman KB, Lathrop M, Schwarz MI, Schwartz DA Nat. Genet. 2013 Apr

Long-range PCR based sequencing of the highly homologous genes, SFTPA1 and SFTPA2.

Horton CJ, Mitui M, Leos NK, Garcia CK, Park JY Mol. Cell. Probes 2013 Jan

Lung fibrosis, premature graying, and macrocytosis.

Chambers DC, Clarke BE, McGaughran J, Garcia CK Am. J. Respir. Crit. Care Med. 2012 Sep 186 5 e8-9

Red blood cell size is inversely associated with leukocyte telomere length in a large multi-ethnic population.

Kozlitina J, Garcia CK PLoS ONE 2012 7 12 e51046

Subclinical Lung Disease, Macrocytosis and Premature Graying in Kindreds with Telomerase (TERT) Mutations.

Diaz de Leon A, Cronkhite JT, Yilmaz C, Brewington C, Wang R, Xing C, Hsia CC, Garcia CK Chest 2011 Feb 753-63

Results 1-10 of 17

Books

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Featured Books

Honors/Awards

  • American Society for Clinical Investigation
    (2012)
  • Doris Duke Charitable Foundation Clinical Scientist Development Award
    (2008)
  • President's Research Council Young Investigator Award
    (2006)
  • Charles E. Culpeper Medical Scholar
    (2004)
  • Parker B. Francis Fellowship
    (2003)
  • Alpha Omega Alpha
    (1991)

Professional Associations/Affiliations

  • American Society for Clinical Investigation (2012)
  • American Thoracic Society (2007)
  • American Society of Human Genetics (2006)