Education

Undergraduate
Fudan University - China (1999), Microbiology
Graduate School
University of Texas at Austin (2006), Molecular Biology

Research Interest

  • Autoimmune diseases
  • Glycoimmunology
  • HIV pathogenesis
  • innate immunity
  • Retrovirology

Publications

Featured Publications LegendFeatured Publications

Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex.
Kucej M, Fermaintt CS, Yang K, Irizarry-Caro RA, Yan N Cell Rep 2017 Mar 18 11 2600-2607
DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.
Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC J. Autoimmun. 2017 Mar
Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.
Hasan M, Gonugunta VK, Dobbs N, Ali A, Palchik G, Calvaruso MA, DeBerardinis RJ, Yan N Proc. Natl. Acad. Sci. U.S.A. 2017 Jan
RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.
Pokatayev V, Hasin N, Chon H, Cerritelli SM, Sakhuja K, Ward JM, Morris HD, Yan N, Crouch RJ J. Exp. Med. 2016 Feb
Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice.
Hasan M, Dobbs N, Khan S, White MA, Wakeland EK, Li QZ, Yan N J. Immunol. 2015 Oct
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.
Hasan M, Fermaintt CS, Gao N, Sakai T, Miyazaki T, Jiang S, Li QZ, Atkinson JP, Morse HC, Lehrman MA, Yan N Immunity 2015 Aug
STING activation by translocation from the ER is associated with infection and autoinflammatory disease.
Dobbs N, Burnaevskiy N, Chen D, Gonugunta VK, Alto NM, Yan N. Cell Host & Microbe 2015 18 1 1-12
Safeguard against DNA sensing: the role of TREX1 in HIV-1 infection and autoimmune diseases.
Hasan M, Yan N Front Microbiol 2014 5 193
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.
Gao D, Wu J, Wu YT, Du F, Aroh C, Yan N, Sun L, Chen ZJ Science 2013 Aug 341 6148 903-6
Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.
Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N Nat. Immunol. 2013 Jan 14 1 61-71

Honors & Awards

  • Burroughs Wellcome PATH Investigator
    (2015)
  • Endowed Scholar Award, UTSW
    (2011)
  • NIAID Career Development Award
    (2011)
  • Young Investigator Award, CORI
    (2008)
  • Center for AIDS Research (CFAR) Scholar Award
    (2007)