Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.
Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N Nat. Immunol. 2013 Jan 14 1 61-71
The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.
Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J. Nat Immunol. November 2010 11(11) 1005-13
SAMHD1 does it again, now in resting T cells.
Yan N, Lieberman J Nat. Med. 2012 Nov 18 11 1611-2
Intrinsic antiviral immunity.
Yan N, Chen ZJ Nat. Immunol. 2012 Mar 13 3 214-22
HIV DNA is heavily uracilated, which protects it from autointegration.
Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman J Proc. Natl. Acad. Sci. U.S.A. 2011 May 108 22 9244-9
Gaining a foothold: how HIV avoids innate immune recognition.
Yan N, Lieberman J. Curr Opin Immunol. February 2011 23(1) 21-8
The SET complex acts as a barrier to autointegration of HIV-1.
Yan N, Cherepanov P, Daigle JE, Engelman A, Lieberman J. PLoS Pathog. March 2009 5(3) e1000327
Identification of host proteins required for HIV infection through a functional genomic screen.
Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ. Science February 2008 319(5865) 921-6