Education

Undergraduate
Fudan University (1999), Microbiology
Graduate School
University of Texas at Austin (2006), Molecular Biology

Research Interest

  • Autoimmune diseases
  • Glycoimmunology
  • HIV pathogenesis
  • innate immunity
  • Retrovirology

Publications

Featured Publications LegendFeatured Publications

STING-associated vasculopathy develops independently of IRF3 in mice.
Warner JD, Irizarry-Caro RA, Bennion BG, Ai TL, Smith AM, Miner CA, Sakai T, Gonugunta VK, Wu J, Platt DJ, Yan N, Miner JJ J. Exp. Med. 2017 Sep
Immune Diseases Associated with TREX1 and STING Dysfunction.
Yan N J. Interferon Cytokine Res. 2017 May 37 5 198-206
Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex.
Kucej M, Fermaintt CS, Yang K, Irizarry-Caro RA, Yan N Cell Rep 2017 Mar 18 11 2600-2607
DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.
Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC J. Autoimmun. 2017 Mar
Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.
Hasan M, Gonugunta VK, Dobbs N, Ali A, Palchik G, Calvaruso MA, DeBerardinis RJ, Yan N Proc. Natl. Acad. Sci. U.S.A. 2017 Jan
Methods of Assessing STING Activation and Trafficking.
Pokatayev V, Yan N Methods Mol. Biol. 2017 1656 167-174
RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.
Pokatayev V, Hasin N, Chon H, Cerritelli SM, Sakhuja K, Ward JM, Morris HD, Yan N, Crouch RJ J. Exp. Med. 2016 Feb
Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice.
Hasan M, Dobbs N, Khan S, White MA, Wakeland EK, Li QZ, Yan N J. Immunol. 2015 Oct
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.
Hasan M, Fermaintt CS, Gao N, Sakai T, Miyazaki T, Jiang S, Li QZ, Atkinson JP, Morse HC, Lehrman MA, Yan N Immunity 2015 Aug
STING activation by translocation from the ER is associated with infection and autoinflammatory disease.
Dobbs N, Burnaevskiy N, Chen D, Gonugunta VK, Alto NM, Yan N. Cell Host & Microbe 2015 18 1 1-12

Honors & Awards

  • Burroughs Wellcome PATH Investigator
    (2015)
  • Endowed Scholar Award, UTSW
    (2011)
  • NIAID Career Development Award
    (2011)
  • Young Investigator Award, CORI
    (2008)
  • Center for AIDS Research (CFAR) Scholar Award
    (2007)