Dr. Ye is originally from China and received his PhD at the University of Southern California in Los Angeles, California. Drawn by the excellent environment in metabolic studies, he completed his postdoctoral training with Dr. Philipp Scherer at UTSouthwestern. Dr. Ye brings to UTSW a strong background in biochemistry, molecular genetics and metabolism. He currently focuses his research on metabolic disorders and related diseases, especially the insulin-producing pancreatic beta-cells. Dr. Ye’s interests outside of academics include his family, reading, and competitive badminton.
- (2002), Biochemistry
- Graduate School
- University of Southern Califor (2010), Biochemistry
- Acute Pancreatitis
- Insulin-Producing Beta Cells
- Lipid Metabolism
- SNARE Proteins
- Autonomous interconversion between adult pancreatic a-cells and ß-cells after differential metabolic challenges.
- Ye R, Wang M, Wang QA, Spurgin SB, Wang ZV, Sun K, Scherer PE Mol Metab 2016 Jul 5 7 437-48
- MitoNEET-Parkin Effects in Pancreatic a- and ß-Cells, Cellular Survival, and Intrainsular Cross Talk.
- Kusminski CM, Chen S, Ye R, Sun K, Wang QA, Spurgin SB, Sanders PE, Brozinick JT, Geldenhuys WJ, Li WH, Unger RH, Scherer PE Diabetes 2016 Jun 65 6 1534-55
- Impact of tamoxifen on adipocyte lineage tracing: Inducer of adipogenesis and prolonged nuclear translocation of Cre recombinase.
- Ye R, Wang QA, Tao C, Vishvanath L, Shao M, McDonald JG, Gupta RK, Scherer PE Mol Metab 2015 Nov 4 11 771-8
- Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation.
- Wang QA, Tao C, Jiang L, Shao M, Ye R, Zhu Y, Gordillo R, Ali A, Lian Y, Holland WL, Gupta RK, Scherer PE Nat. Cell Biol. 2015 Sep 17 9 1099-111
- Adiponectin-mediated antilipotoxic effects in regenerating pancreatic islets.
- Ye R, Wang M, Wang QA, Scherer PE Endocrinology 2015 Jun 156 6 2019-28
- Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes ß-cell regeneration.
- Ye R, Holland WL, Gordillo R, Wang M, Wang QA, Shao M, Morley TS, Gupta RK, Stahl A, Scherer PE Elife 2014 Oct 3
- Adiponectin, driver or passenger on the road to insulin sensitivity?
- Ye R, Scherer PE Mol Metab 2013 Apr 2 3 133-41
- Inositol 1,4,5-trisphosphate receptor 1 mutation perturbs glucose homeostasis and enhances susceptibility to diet-induced diabetes.
- Ye R, Ni M, Wang M, Luo S, Zhu G, Chow RH, Lee AS J. Endocrinol. 2011 Aug 210 2 209-17
- Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis.
- Ye R, Mareninova OA, Barron E, Wang M, Hinton DR, Pandol SJ, Lee AS Am. J. Pathol. 2010 Dec 177 6 2827-36
- Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance.
- Ye R, Jung DY, Jun JY, Li J, Luo S, Ko HJ, Kim JK, Lee AS Diabetes 2010 Jan 59 1 6-16
The ER Chaperone GRP78 and Cancer. In Protein Misfolding Disorders: A Trip into the ER
Ye R, Zhang Y, Lee AS (2009). Bentham Science Publishers
Honors & Awards
- Advanced Postdoctoral Fellowship
JDRF (Juvenile Diabetes Research Foundation (2017-2019)
- Keystone Symposia Scholarship
Keystone Symposia Conference - Diabetes and Metabolic Dysfunction (2015)
- Naomi Berrie Research Fellowship
Naomi Berrie Diabetes Center, Columbia University Medical Center (2013-2015)
- Keystone Symposia Global Health Travel Award
Keystone Symposia Conference - Advances in Islet Biology (2012)
- Postdoctoral Fellowship
American Heart Association (2011-2013)