Biography

Dr. Plattner received a bachelor’s degree in Molecular Biology from the University of Basel, Basel, Switzerland, and a master’s degree in Biotechnology from the European School of Biotechnology, Strasbourg, France. He graduated with a PhD in Neurosciences from the University College of London, London, UK. For his post-doctorate, he joined the UCL Queen Square Brain Bank, London, UK, on a Postdoctoral Fellowship from the Alzheimer’s Research Trust, Cambridge, UK. Dr. Plattner currently works as an Assistant Professor in the Department of Psychiatry at UT Southwestern Medical Center, Dallas, TX and the Center for Translational Neurodegeneration Research in the Department of Molecular Genetics. 

Dr. Plattner's research interests are the molecular mechanisms underlying learning & memory and their role in neurological disorders. In particular, he is focusing on intracellular signaling mechanisms involving the protein kinases Cdk5, GSK3 and PKA to investigate neuronal processes, including neurotransmission, synaptic plasticity and memory formation, and their dysfunction in neurodegenerative diseases, including Alzheimer’s disease (AD). In his studies, Dr. Plattner employs an integrative, multi-disciplinary approach that comprises biochemical, pharmacological, neurophysiological and behavioral analysis of virus-mediated and genetically-modified mouse models as well as the development and application of small-interfering peptides (siPs). Notably, he established in vivo administration of siPs as a powerful technique for the exploration of signalling mechanisms involved with memory formation.

As part of his research at UTSW, Dr. Plattner characterized a novel NMDA receptor-associated mechanism that can be targeted to enhance memory (Plattner et al., 2014 Neuron). Recently, he uncovered a new mechanism that regulates cAMP levels and cAMP-dependent protein kinase (PKA) and thereby contributes to stress-induced behavioral responses (Plattner et al., 2015 Nat. Neurosci.). Mechanistic insights gained in these studies can now be translated into the identification of novel therapeutic targets and development of new treatment strategies for neurodegenerative diseases, including Alzheimer’s disease.

Education

Undergraduate
University of Basel (1998), Molecular Biology
Graduate School
University of Strasbourg (2001), Biotechnology
Graduate School
University College London (2006), Neuroscience

Research Interest

  • Alzheimer's disease
  • Intracellular signaling pathways
  • Memory functions
  • Neurodegenerative diseases
  • Neuroscience
  • Synaptic plasticity

Publications

Featured Publications LegendFeatured Publications

The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines.
Liang Z, Zhan Y, Shen Y, Wong CC, Yates JR, Plattner F, Lai KO, Ip NY Nat Commun 2016 Oct 7 13282
Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain.
Tassin TC, Benavides DR, Plattner F, Nishi A, Bibb JA J. Biol. Chem. 2015 Jun 290 26 16319-29
Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis.
Pozo K, Hillmann A, Augustyn A, Plattner F, Hai T, Singh T, Ramezani S, Sun X, Pfragner R, Minna JD, Cote GJ, Chen H, Bibb JA, Nwariaku FE Oncotarget 2015 Apr
Dynamic range of GSK3a not GSK3ß is essential for bidirectional synaptic plasticity at hippocampal CA3-CA1 synapses.
Shahab L, Plattner F, Irvine EE, Cummings DM, Edwards FA Hippocampus 2014 Sep
Ischemic stroke injury is mediated by aberrant cdk5.
Meyer DA, Torres-Altoro MI, Tan Z, Tozzi A, Di Filippo M, DiNapoli V, Plattner F, Kansy JW, Benkovic SA, Huber JD, Miller DB, Greengard P, Calabresi P, Rosen CL, Bibb JA J. Neurosci. 2014 Jun 34 24 8259-67

Books

Featured Books Legend Featured Books

Honors & Awards

  • Schering Stiftung, Berlin, Germany
    Conference travel grant (2015)
  • Darrell K Royal Research Fund for Alzheimer’s Disease, Austin, TX
    Research grant award (2014-2017)
  • UTSW Friends of the Alzheimer’s Disease Center, Dallas, TX.
    Research grant award (2014-2015)
  • Schering Stiftung, Berlin, Germany
    Travel award (2013)
  • Japanese Society for the Promotion of Science, Tokyo, Japan.
    Short-term Fellowship (2010)
  • Brain Journal, London, UK
    Conference travel grant (2008)
  • Alzheimer’s Research Trust, Cambridge, UK.
    Post-doctoral Fellowship (2006-2008)
  • UCL Graduate School
    Conference travel grant (2005)
  • Aventis, Frankfurt, Germany
    Aventis [i] lab award as conference fund (2004)
  • EMBO/FENS
    Travel award to EMBO/FENS mouse behavior course at University of Zurich, Zurich, Switzerland (2003)
  • Schering Stiftung, Berlin, Germany
    PhD Studentship (2003-2005)
  • Basellandschaftliche Kantonalbank, Liestal, Switzerland.
    PhD Studentship (2002-2005)
  • University of Basel
    EUCOR stipend for undergraduate studies (1998-2001)