Education

Undergraduate Princeton University (1999), Chemistry
Graduate School Harvard University (2005), Chemistry

Research Interest

  • G protein-coupled receptors
  • membrane protein structural biology
  • molecular recognition

Publications

Featured Publications LegendFeatured Publications

Structure and dynamics of the M3 muscarinic acetylcholine receptor.

Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK Nature 2012 Feb 482 7386 552-6

Structure of a nanobody-stabilized active state of the ß(2) adrenoceptor.

Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK Nature 2011 Jan 469 7329 175-80

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.

Bokoch MP, Zou Y, Rasmussen SG, Liu CW, Nygaard R, Rosenbaum DM, Fung JJ, Choi HJ, Thian FS, Kobilka TS, Puglisi JD, Weis WI, Pardo L, Prosser RS, Mueller L, Kobilka BK Nature 2010 Jan 463 7277 108-12

Structure-based discovery of beta2-adrenergic receptor ligands.

Kolb P, Rosenbaum DM, Irwin JJ, Fung JJ, Kobilka BK, Shoichet BK Proc. Natl. Acad. Sci. U.S.A. 2009 Apr 106 16 6843-8

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC Science 2007 Nov 318 5854 1258-65

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK Nature 2007 Nov 450 7168 383-7

Honors & Awards

  • Packard Fellow
    (2012)
  • Searle Scholar
    (2012)
  • UTSW Endowed Scholar
    (2010)
  • NIH NRSA Postdoctoral Fellowship
    (2007)