Education

Medical School
Univeristy of Hong Kong (2000)
Internship
Hospital Authority of Hong Kong (2001), Rotating
Residency
Goryeb Children's Hospital - Atlantic Health (2007), Pediatrics
Fellowship
Emory University School of Medicine/Grady Memorial Hospital (2010), Neonatal-perinatal Medicine

Specialty Areas

Clinical Interest

  • Immunology
  • Microbiota
  • Necrotizing Enterocolitis
  • Neonatal Nutrition
  • Research Interest

    • Probiotics/Commensal organisms and their effects on immune mediators in the developing gut

    Publications

    Featured Publications LegendFeatured Publications

    Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi.
    Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, Yarovinsky F Cell 2016 Feb 164 5 827-8
    The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia.
    Liao J, Kapadia VS, Brown LS, Cheong N, Longoria C, Mija D, Ramgopal M, Mirpuri J, McCurnin DC, Savani RC Nat Commun 2015 6 8977
    Proteobacteria-specific IgA regulates maturation of the intestinal microbiota.
    Mirpuri J, Raetz M, Sturge CR, Wilhelm CL, Benson A, Savani RC, Hooper LV, Yarovinsky F Gut Microbes 2013 Sep 5 1
    TLR-independent neutrophil-derived IFN-? is important for host resistance to intracellular pathogens.
    Sturge CR, Benson A, Raetz M, Wilhelm CL, Mirpuri J, Vitetta ES, Yarovinsky F Proc. Natl. Acad. Sci. U.S.A. 2013 Jun 110 26 10711-6
    Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-?-dependent elimination of Paneth cells.
    Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F Nat. Immunol. 2013 Feb 14 2 136-42
    Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii.
    McBerry C, Egan CE, Rani R, Yang Y, Wu D, Boespflug N, Boon L, Butcher B, Mirpuri J, Hogan SP, Denkers EY, Aliberti J, Herbert DR J. Immunol. 2012 Sep 189 6 3078-84
    B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage.
    Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F Immunity 2012 Feb 36 2 228-38
    IL-6 signaling SOCS critical for IL-12 host response to Toxoplasma gondii.
    Mirpuri J, Yarovinsky F Future Microbiol 2012 Jan 7 1 13-6
    Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.
    Broadhurst MJ, Ardeshir A, Kanwar B, Mirpuri J, Gundra UM, Leung JM, Wiens KE, Vujkovic-Cvijin I, Kim CC, Yarovinsky F, Lerche NW, McCune JM, Loke P PLoS Pathog. 2012 8 11 e1003000
    Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit.
    Mirpuri J, Sotnikov I, Myers L, Denning TL, Yarovinsky F, Parkos CA, Denning PW, Louis NA PLoS ONE 2012 7 12 e51955

    Honors & Awards

    • FASEB Travel Scholarship
      (2011)
    • Basic Science Young Investigator Award, Southern Society for Pediatric Research
      (2010)
    • SPR Fellow Basic Science Research Award
      (2010)
    • Trainee Travel Award, Southern Society for Pediatric Research
      (2009)
    • Travel Grant, Pediatric Academic Societies
      (2009)

    Professional Associations/Affiliations

    • The American Association of Immunologists (2013)
    • Southern Society for Pediatric Research (2007)
    • American Academy of Pediatrics (2004)
    • Medical Council of Hong Kong