Shuzhen Liu, Ph.D.

Shuzhen Liu, Ph.D., is an Instructor in the Department of Internal Medicine at UT Southwestern Medical Center.

Originally from China, Dr. Liu holds a bachelor's degree in microbiology from Shanxi University in China. She earned a master's degree in biochemistry and molecular biology at the Institute of Microbiology Chinese Academy of Sciences. She then earned her doctoral degree at the University of Rostock and Leibniz Institute for Farm Animal Bioogy in Germany. She complerted postdoctoral training in cell biology and molecular biology at UT Southwestern Medical Center.

Dr. Liu joined the UT Southwestern faculty in 2016 as an Assistant Instructor in the Department of Molecular Biology. She was promoted to Instructor in 2018 and then joined the Department of Internal Medicine as an Instructor in 2020.

Dr. Liu's research interests are farm animal biology, necroptosis, and microbiology.

Undergraduate

(2016), Microbiology

Graduate School

(2016), Molecular Biology

Graduate School

(2016), None

Graduate School

(2016), Biochemistry

• Cancer
• Inflammation
• Necroptosis

Featured Publications

Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis.

Johnston AN, Ma Y, Liu H, Liu S, Hanna-Addams S, Chen S, Chen C, Wang Z, Proc. Natl. Acad. Sci. U.S.A. 2020 Mar 117 12 6521-6530

CK1a, CK1d, and CK1e are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis.

Hanna-Addams S, Liu S, Liu H, Chen S, Wang Z, Proc. Natl. Acad. Sci. U.S.A. 2020 Jan 117 4 1962-1970

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis.

Liu S, Liu H, Johnston A, Hanna-Addams S, Reynoso E, Xiang Y, Wang Z Proc. Natl. Acad. Sci. U.S.A. 2017 Aug

The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection.

Hu MC, Shi M, Cho HJ, Zhang J, Pavlenco A, Liu S, Sidhu S, Huang LJ, Moe OW Kidney Int. 2013 May

Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-?B p65 and C/EBP? in mammary epithelial cells.

Liu S, Shi X, Bauer I, Günther J, Seyfert HM, Mol. Immunol. 2011 Mar 48 6-7 895-908

Salmonid Tollip and MyD88 factors can functionally replace their mammalian orthologues in TLR-mediated trout SAA promoter activation.

Rebl A, Rebl H, Liu S, Goldammer T, Seyfert HM, Dev. Comp. Immunol. 2011 Jan 35 1 81-7

C/EBP-beta drives expression of the nutritionally regulated promoter IA of the acetyl-CoA carboxylase-alpha gene in cattle.

Shi X, Liu S, Metges CC, Seyfert HM, Biochim. Biophys. Acta 2010 Aug 1799 8 561-7

Stimulated expression of TNF-alpha and IL-8, but not of lingual antimicrobial peptide reflects the concentration of pathogens contacting bovine mammary epithelial cells.

Günther J, Liu S, Esch K, Schuberth HJ, Seyfert HM, Vet. Immunol. Immunopathol. 2010 May 135 1-2 152-157

Molecular cloning and characterization of a laccase gene from the basidiomycete Fome lignosus and expression in Pichia pastoris.

Liu W, Chao Y, Liu S, Bao H, Qian S, Appl. Microbiol. Biotechnol. 2003 Dec 63 2 174-81