Featured Publications
Real-time detection of ERAD substrate retro-translocation in a mammalian in vitro system.
Wahlman, J, DeMartino, GN, Skach, WR, Bulleid, NJ, Brodsky, JL and Johnson, AE Cell 2007 129 943-955
ATP binding and ATP hydrolysis play distinct roes in the function of 26S proteasome.
Liu, C, Li, X, Thompson, D, Wooding, K, Chang, T, Tang, Z, Yu, H, Thomas, PJ, and DeMartino, GN Mol Cell 2006 24 39-50
VCP is a regulator of ER stress involved in the degradation of multiple substrates of the ubiquitin-proteasome system in mammalian cells.
Wojcik C, Rowicka, M, Kudlicki, A, Nowis, D, Adams, GM, Kujawa, M, and DeMartino GN Mol Biol Cell 2006 17 4606-4618
Endoproteolytic activity of the proteasome.
Liu, CW, Corboy, MJ, DeMartino, GN, and Thomas, PJ Science 2003 299 408-411
Identification, purification, and characterization of a high molecular weight ATP-dependent activator (PA700) of the 20S proteasome.
Ma, C-P, Vu, JH, Proske, RJ, Slaughter, CA, and DeMartino, GN J Biol Chem 1994 269 3539-3547
Identification, purification and characterization of a protein activator (PA28) of the 20S proteasome (macropain).
Ma, C-P, Slaughter, CA, and DeMartino, GN J Biol Chem 1992 267 10515-10523
RNA interference of VCP reveals multiple cellular roles linked to ubiquitin-proteasome dependent proteolysis.
Wojcik, C, Yano, M, and DeMartino, GN J Cell Sci 2004 117 281-92
The latent form of macropain (high molecular weight multicatalytic protease) restores ATP-dependent proteolysis to cell-free extracts of BHK fibroblasts pretreated with antimacropain antibodies.
McGuire, MJ, McCullough, ML, Croall, DE, and DeMartino, GN Biochim Biophys Acta 1989 995 181-186
Identification and partial purification of an ATP-stimulated alkaline protease in rat liver.
DeMartino, GN and Goldberg, AL J Biol Chem 1979 254 3712-3715
