George DeMartino, Ph.D.

Undergraduate

Union College (1971), Chemistry

Graduate School

University of Rochester (1976), Biochemistry

• Mechanisms and regulation of intracellular protein degradation
• Mechansms and regulation of muscle growth and atrophy
• Proteasome structure, function, and regulation
• Ubiquitin-proteasome system

Featured Publications

Molecular and Cellular Roles of PI31 (PSMF1) in Regulation of Proteasome Function.

Li X, Thompson D, Kumar B, Demartino GN J. Biol. Chem. 2014 Apr

ATP Binding by Proteasomal ATPases Regulates Cellular Assembly and Substrate-induced Functions of the 26 S Proteasome.

Kim YC, Li X, Thompson D, Demartino GN J. Biol. Chem. 2013 Feb 288 5 3334-45

C termini of proteasomal ATPases play nonequivalent roles in cellular assembly of Mammalian 26 s proteasome.

Kim YC, Demartino GN J. Biol. Chem. 2011 Jul 286 30 26652-66

PSMB8 encoding the ?5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome.

Agarwal AK, Xing C, DeMartino GN, Mizrachi D, Hernandez MD, Sousa AB, Martínez de Villarreal L, dos Santos HG, Garg A Am. J. Hum. Genet. 2010 Dec 87 6 866-72

The C terminus of Rpt3, an ATPase subunit of PA700 (19 S) regulatory complex, is essential for 26 S proteasome assembly but not for activation.

Kumar B, Kim YC, DeMartino GN J. Biol. Chem. 2010 Dec 285 50 39523-35

Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome.

Gillette TG, Kumar B, Thompson D, Slaughter CA, DeMartino GN J. Biol. Chem. 2008 Nov 283 46 31813-22

Real-time detection of ERAD substrate retro-translocation in a mammalian in vitro system.

Wahlman, J, DeMartino, GN, Skach, WR, Bulleid, NJ, Brodsky, JL and Johnson, AE Cell 2007 129 943-955

ATP binding and ATP hydrolysis play distinct roes in the function of 26S proteasome.

Liu, C, Li, X, Thompson, D, Wooding, K, Chang, T, Tang, Z, Yu, H, Thomas, PJ, and DeMartino, GN Mol Cell 2006 24 39-50

• UT Regents Outstanding Teaching Award
  (2013)
• Distinguished Basic Science Educator Award
  UT Southwestern Medical School (2011-2012)
• Visiting Professor
  University of Coimbra Medical School, Coimbra, Portugal (2005)
• Leon L. Miller Lecturer
  University of Rochester School of Medicine (2003)
• Chair, FASEB Summer Research Conference on Ubiquitin
  (1999-2001)
• The Robert W. Lackey Professorship in Physiology
  (1996)
• Muscular Dystrophy Association Postdoctoral Fellowship
  Harvard Medical School (1978-1979)
• NIH Postdoctoral Fellowship
  Harvard Medical School (1976-1978)
• Wallace Osgood Fenn Award
  University of Rochester School of Medicine (1976)

• American Physiological Society
• American Society for Biological Chemistry and Molecular Biology
• American Society for Cell Biology