James De Lemos, M.D.

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 Dr. de Lemos is Professor of medicine and holds the Sweetheart Ball-Kern Wildenthal, MD, PhD Distinguished Chair in Cardiology.  He is the Cardiology Service Chief at Parkland Memorial Hospital where he also serves as CCU Director.  He was the director of the Cardiology Fellowship at UT Southwestern from 2005-2011. He is an active investigator in the Donald W. Reynolds Cardiovascular Research Center at UT Southwestern, and the Medical Director of the Dallas Heart Study.   He has chaired or co-chaired several research planning committees at UT Southwestern.  His primary research interests are in early detection, risk assessment and management of cardiovascular disease, with a particular focus on the role of cardiovascular biomarkers.  His research has evaluated existing biomarkers such as B-type natriuretic peptide, C-reactive protein and cardiac troponins as well as novel biomarkers reflecting biological pathways of disease.  He was the lead author of the Z phase of the A to Z trial, an international trial investigating different cholesterol lowering strategies in patients with acute coronary syndromes.  He graduated from Harvard Medical School and completed an Internal Medicine Residency at UT Southwestern Medical Center, where he also served as Chief Medical Resident.  He completed a fellowship in Cardiovascular Medicine and served on the faculty at the Brigham and Women’s Hospital before returning to UT Southwestern Medical School.  He has served on multiple committees of the AHA and ACC and is on the editorial board of the Journal of the American College of Cardiology, the American Journal of Cardiology and the American Heart Journal.  He has mentored >25 post-doctoral research trainees and has authored or coauthored over 250 manuscripts or book chapters and won several teaching awards. He sees patients with a broad range of cardiac problems, but specializes in those with chest pain and coronary artery disease.

Medical School	Harvard Medical School (1992)
Internship	UT Southwestern Medical Center (1993), Internal Medicine
Residency	UT Southwestern Medical Center (1995), Internal Medicine
Chief Resident	UT Southwestern Medical Center (1996), Internal Medicine
Fellowship	Harvard Medical School (1999), Cardiology

• General Cardiology
• Heart (Cardiology)

• Primary Interests
• Angina Pectoris
• Atrial Fibrillation & Flutter
• Bradycardia
• Cardiac Arrhythmias (Irregular Heartbeats)
• Cardiomyopathy
• Cholesterol - Dyslipidemia, Hypercholesterolemia, Hyperlipidemia
• Coronary Artery Disease
• Endocarditis
• Heart Palpitations
• Left or Right Heart Failure (Congestive Heart Failure)
• Myocardial Infarction (Heart Attack)
• Pulmonary Valve Stenosis & Regurgitation
• Syncope (Fainting)
• Tachycardia - Superventricular (SVT) & Paroxysmal Superventricular (PSVT)

• Acute Coronary Sydromes
• Cardiac Biomarkers
• Lipid Lowering Therapy
• Screening for Cardiovascular Disease

Featured Publications

Impact of body weight and extreme obesity on the presentation, treatment, and in-hospital outcomes of 50,149 patients with ST-Segment elevation myocardial infarction results from the NCDR (National Cardiovascular Data Registry).

Das SR, Alexander KP, Chen AY, Powell-Wiley TM, Diercks DB, Peterson ED, Roe MT, de Lemos JA J. Am. Coll. Cardiol. 2011 Dec 58 25 2642-50

Biomarkers in clinical trials: can we move from fortune telling to disease profiling?

de Lemos JA, McGuire DK Circulation 2011 Aug 124 6 663-5

Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population.

de Lemos JA, Drazner MH, Omland T, Ayers CR, Khera A, Rohatgi A, Hashim I, Berry JD, Das SR, Morrow DA, McGuire DK JAMA 2010 Dec 304 22 2503-12

Early Intensive vs a Delayed Conservative Simvastatin Strategy in Patients With Acute Coronary Syndromes: Phase Z of the A to Z Trial

46. de Lemos JA, Blazing MA, Wiviott SD, Lewis EF, Fox KA, White HD, Rouleau JL, Pedersen TR, Gardner LH, Mukherjee R, Ramsey KE, Palmisano J, Bilheimer DW, Pfeffer MA, Califf RM, Braunwald E JAMA 2004 292 1303-17

Enoxaparin versus unfractionated heparin in patients treated with tirofiban, aspirin and an early conservative initial management strategy: results from the A phase of the A to Z trial

47. de Lemos JA, Blazing MA, Wiviott SD, Brady WE, White HD, Fox KAA, Palmisano J, Ramsey KE, Bilheimer D, Lewis EF, Califf RM, Braunwald E Eur Heart J 2004 25 1688-94

The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes

de Lemos JA, Morrow DA, Bentley JH, Omland T, Sabatine MS, McCabe CH, Hall C, Cannon CP, Braunwald E New England Journal of Medcine September 2001 345 1014-21

Low levels of circulating troponin as an intermediate phenotype in the pathway to heart failure.

de Lemos JA, Grundy SM J. Am. Coll. Cardiol. 2012 Jan 59 5 490-2

Association of growth differentiation factor-15 with coronary atherosclerosis and mortality in a young, multiethnic population: observations from the Dallas Heart Study.

Rohatgi A, Patel P, Das SR, Ayers CR, Khera A, Martinez-Rumayor A, Berry JD, McGuire DK, de Lemos JA Clin. Chem. 2012 Jan 58 1 172-82

No free lunches: balancing bleeding and efficacy with ticagrelor.

de Lemos JA, Brilakis ES Eur. Heart J. 2011 Dec 32 23 2919-21

Race-specific associations of myeloperoxidase with atherosclerosis in a population-based sample: the Dallas Heart Study.

Chen LQ, Rohatgi A, Ayers CR, Das SR, Khera A, Berry JD, McGuire DK, de Lemos JA Atherosclerosis 2011 Dec 219 2 833-8

Featured Books

Biomarkers in Heart Disease

de Lemos JA (Ed.) (2008). Blackwell Publishing

Cardiovascular Therapeutics: A companion to Braunwald's Heart Disease, 3rd ed

de Lemos JA (Ed.) (2007). Saunders

Unstable Angina and Non-ST Elevation Myocardial Infarction. In Hurst's the Heart, 13th ed

de Lemos JA, O'Rourke RA, Harrington RA (2011). McGraw Hill

ST Elevation Myocardial infarction. In Irwin and Rippe?s Intensive Care Medicine 7th edition

de Lemos JA and Morrow DA (2011). William and Wilkins

• Simon Dack Award for Medical Publications
  Journal of the American College of Cardiology (2012)
• Association of University Cardiologists
  (2011)
• Best Doctors in Dallas, Cardiology
  D Magazine (2011)
• Core Clerkship Teaching Award
  UT Southwestern (2011)
• Super Doctors, Cardiology
  Texas Monthly (2011)
• Best Doctors in Dallas, Cardiology
  D Magazine (2010)
• Super Doctors, Cardiology
  Texas Monthly (2010)
• Sweetheart Ball-Kern Wildenthal MD, PhD Dintinguished Chair
  Distinguished Chair in Cardiology (2009)
• Elite Reviewer
  Journal of the American College of Cardiology (2006)
• Best Doctors in Dallas, Cardiology
  D Magazine (2005)
• Internal Medicine Teaching Award
  Excellence in Teaching (2005)
• Eugene Braunwald Fellowship
  Excellence in Clinical Research, Brigham and Women’s Hospital (1999)
• Soma Weiss Award
  Excellence in Teaching, Brigham and Women’s Hospital (1997)

• Society of Chest Pain Physicians (2011)
• AHA/ACC ST Elevation MI Guideline Committee (2010-2012)
• Chair, Research and Publications Committee (2010)
• American Heart Association (1998)
• American College of Cardiology (1996)