Dr. Davis is currently a member of the Department of Internal Medicine and Harold C. Simmons Arthritis Research Center and faculty of the Immunology Graduate Program. The Davis laboratory has focused on mechanisms regulating T lymphocyte activation and differentiation. The laboratory has also developed an interest in the altered immune responses observed in patients with autoimmune diseases.
The laboratory currently has two main areas of investigation. First, the researchers are interested in understanding human CD4+ T cell differentiation and cytokine production. These studies evaluate the influences, such as antigen-presenting cells, that direct T helper cell differentiation. Other studies attempt to examine the role of CD4+ T cells in the perpetuation of chronic inflammatory diseases. A second area of investigation involves the search for new markers of human autoimmunity and disease severity. For these studies, both innate and immune subsets of blood cells from patients with autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis are compared to healthy controls by gene expression profiling and extensive phenotyping. These studies will elucidate molecular pathways that are altered by autoimmune diseases and could identify novel therapeutic targets.
- Lamar University-Beaumont (1979), Biology
- Graduate School
- University of Texas Southwestern Med Ctr Dallas (1987), Molecular Immunology
- Molecular Mechanisms Inducing Autoimmunity
- T Lymphocyte Activation
- Inflammation, immune reactivity, and angiogenesis in a SCID model of rheumatoid arthritis
- LS Davis, M Sackler, RI Brezinschek, E Lightfoot, JL Bailey, N Oppenheimer-Marks, PE Lipsky Amer J Pathol 2002 160 357-367
- Differentiation of human memory T cells into Th2-like effector cells is dependent on IL-4 and CD28 stimulation and inhibited by T cell receptor ligation
- H Schulze-Koops, PE Lipsky, and LS Davis European Journal of Immunology 1998 28 2517-2529
- Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis
- LS Davis, AF Kavanaugh, LA Nichols and PE Lipsky Journal of Immunology 1995 154 3523-3537
- Antibody-independent B cell effector functions in relapsing remitting Multiple Sclerosis: Clues to increased inflammatory and reduced regulatory B cell capacity.
- Ireland SJ, Blazek M, Harp CT, Greenberg B, Frohman EM, Davis LS, Monson NL Autoimmunity 2012 Apr
- IL-12 selectively programs effector pathways that are stably expressed in human CD8+ effector memory T cells in vivo.
- Chowdhury FZ, Ramos HJ, Davis LS, Forman J, Farrar JD Blood 2011 Oct 118 14 3890-900
- Early gene expression changes with rush immunotherapy.
- Davis LS, Bhutani S, Barnett SR, Khan DA Clin Mol Allergy 2011 9 12
- Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus.
- Wang A, Guilpain P, Chong BF, Chouzenoux S, Guillevin L, Du Y, Zhou XJ, Lin F, Fairhurst AM, Boudreaux C, Roux C, Wakeland EK, Davis LS, Batteux F, Mohan C Arthritis Rheum. 2010 Nov 62 11 3436-46
- Peripheral blood mononuclear cells from allergic fungal rhinosinusitis adults elicit a Th2 cytokine response to fungal antigens
- A Luong, LS Davis and BF Marple Amer J Rhinology 2009 (in press)
- Cutting Edge: A T-bet independent role for IFN-a/b in regulating IL-2 secretion in human CD4+ central memory T cells
- AM Davis, HJ Ramos, LS Davis and JD Farrar J Immunol December 2008 181 8204-8208
- Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity.
- J Hutcheson, JC Scatizzi, AM Siddiqui, GK Haines 3rd, T Wu, QZ Li, LS Davis, C Mohan and H Perlman. Immunity February 2008 28 206-217
- American Association of Immunologists
- American College of Rheumatology
- American Federation for Clinical Research
- Associate Editor, Journal of Immunology 1993-98