Jeffrey SoRelle, M.D.

Dr. Jeff SoRelle is from Waco and earned his B.S. degree in Chemistry from Centre College in Danville, Kentucky before returning to Texas for medical school at UT Southwestern. First through an AOA summer fellowship and subsequently for a year as a Howard Hughes Research Fellow, Jeff worked in the lab of 2011 Nobel Prize winner, Dr. Bruce Beutler, screening mutagenized mice for genetic regulators of the allergic IgE antibody response.

Upon graduating medical school, Dr. SoRelle completed a residency in Clinical Pathology and fellowship in Molecular Genetic Pathology at UT Southwestern. Dr. SoRelle served as Chief Resident and won the Weinberg Resident Research award in 2020 upon graduating Clinical Pathology (CP only) residency. As an assistant professor, Dr. SoRelle has opened a  basic science research lab with support from the Disease Oriented Clinical Scholars (DOCS) program. He bridges his clinical and research training as Associate Director of the Next Generation Sequencing Lab within the Once Upon A Time Human Genomics Center. There, he has developed several advanced COVID-19 molecular assays and co-leads the UTSW effort to monitor COVID-19 Variants of Concern, which he writes about as a regular contributor of LABLOGATORY, a blog for Laboratory Medicine Professionals.

He is continues investigation of the genetics of allergy, as he opens a new lab. My lab aims to discover the reasons people get allergies at a genetic level. Then we can translate these findings into diagnostic and therapeutic solutions for patients with allergy. With aggressive enthusiasm, we will follow the data to achieve our aims with teamwork as a guiding principle. We will advance the careers of lab members by developing excellent scientific thinking, and clear written and verbal communication. 

Medical School

UT Southwestern Medical School (2016)

Residency

UT Southwestern Medical Center (2018), Pathology

Fellowship

UT Southwestern Medical Center (2019), Molecular Genetics

Residency

UT Southwestern Medical Center (2020), Pathology

• COVID-19 Variant Surveillance
• Genetics of Allergy
• Genomic Medicine
• Immunology
• Laboratory's role in Transgender Health

Featured Publications

Dominant atopy risk mutations identified by mouse forward genetic analysis.

SoRelle JA, Chen Z, Wang J, Yue T, Choi JH, Wang KW, Zhong X, Hildebrand S, Russell J, Scott L, Xu D, Zhan X, Bu CH, Wang T, Choi M, Tang M, Ludwig S, Zhan X, Li X, Moresco EMY, Beutler B, Allergy 2021 04 76 4 1095-1108

Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation.

Misawa T, SoRelle JA, Choi JH, Yue T, Wang KW, McAlpine W, Wang J, Liu A, Tabeta K, Turer EE, Evers B, Nair-Gill E, Poddar S, Su L, Ou F, Yu L, Russell J, Ludwig S, Zhan X, Hildebrand S, Li X, Tang M, Murray AR, Moresco EMY, Beutler B, Sci Immunol 2020 Jan 5 43

Laboratory Action Plan for Emerging SARS-CoV-2 Variants.

Filkins L, SoRelle JA, Schoggins J, Park JY, Clin Chem 2021 04 67 5 720-723

Different Interpretations of the Same Genetic Data.

SoRelle JA, Gemmell AP, Ross TS, Ann. Intern. Med. 2020 Jun

Assessment of Interlaboratory Variation in the Interpretation of Genomic Test Results in Patients With Epilepsy.

SoRelle JA, Pascual JM, Gotway G, Park JY, JAMA Netw Open 2020 Apr 3 4 e203812

Impact of Hormone Therapy on Laboratory Values in Transgender Patients.

SoRelle JA, Jiao R, Gao E, Veazey J, Frame I, Quinn AM, Day P, Pagels P, Gimpel N, Patel K Clin. Chem. 2019 Jan 65 1 170-179

Clinical Utility of Reinterpreting Previously Reported Genomic Epilepsy Test Results for Pediatric Patients.

SoRelle JA, Thodeson DM, Arnold S, Gotway G, Park JY JAMA Pediatr 2018 Nov e182302

Real-time resolution of point mutations that cause phenovariance in mice.

Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T, Wang Y, Shi H, Wang J, Sun L, SoRelle J, McAlpine W, Hutchins N, Zhan X, Fina M, Gobert R, Quan J, Kreutzer M, Arnett S, Hawkins K, Leach A, Tate C, Daniel C, Reyna C, Prince L, Davis S, Purrington J, Bearden R, Weatherly J, White D, Russell J, Sun Q, Tang M, Li X, Scott L, Moresco EM, McInerney GM, Karlsson Hedestam GB, Xie Y, Beutler B Proc. Natl. Acad. Sci. U.S.A. 2015 Jan

• AACC Academy Distinguished Abstract Awards
  (2021)
• Disease Oriented Clinical Scholar (DOCS)
  (2021-2025)
• Weinberg Resident Research award
  (2020)
• Vernie Stembridge Award
  Academic Excellence in Pathology. (2016)

• American Academy of Allergy, Asthma, and Immunology (2019)
• American Association of Immunologists (2017)
• American Society of Clinical Pathology (2016)
• Association for Molecular Pathology (2018)