Dr. Chen’s research is focused on the role of mechanobiology and inflammation in disease initiation, progression, and modification/repair of connective tissues. As a bioengineer, Dr. Chen received his Ph.D. for his works in tissue mechanics (interstitial fluid flow in poroelastic materials) from the University of Wisconsin-Madison. He then joined Cornell University to train in the fields of biochemistry (by Dr. George Lust), mechanobiology, and tissue engineering (Drs. Peter Torzilli and Mary Goldring). He is well recognized for his work in apoptosis and tissue regeneration in post-traumatic osteoarthritis (MSRC Biomechanics Award and Herodicus Award). He joined UT Southwestern Medical Center to expand his horizons and understanding of the molecular mechanisms of musculoskeletal diseases and regeneration. Dr. Chen is also interested in the modification of biomechanical characteristics of diseased tissues. He is currently the director of biomaterials, mechanics, and tissue engineering track in the Biomedical Engineering Program at UTSW. His research has been supported by National Institutes of Health, Department of Defense, and multiple foundations (Arthritis Foundation, ANRF, AOSSM, OTA, AANA and OREF). Dr. Chen has contributed to more than 30 peer-review papers in the fields of musculoskeletal research, regenerative medicine and bioengineering.
- National Taiwan University (1986), Mechanical Engineering
- Graduate School
- University of Wisconsin - Madi (1991), Mechanical Engineering
- Graduate School
- University of Wisconsin - Madi (1996), Biomedical Engineering
- Mechanotransduction and Inflammation Signaling Pathways
- Musculoskeletal Tissue Diseases and Repair (Osteoarthritis and Osteoporosis)
- Osteoclastogenesis and Bone Metastasis
- Tissue Engineering and Regenerative Medicine (Stem Cell Differentiation and Scaffold Design)
- Tissue Mechanics and Biomaterial Assessment
- Relationship Between Serum Uric Acid and Bone Mineral Density in the General Population and in Rats with Experimental Hyperuricemia.
- Zhang D, Bobulescu IA, Maalouf NM, Adams-Huet B, Poindexter J, Park S, Wei F, Chen C, Moe OW, Sakhaee K J. Bone Miner. Res. 2014 Dec
- Topographical Variations of the Strain-dependent Zonal Properties of Tibial Articular Cartilage by Microscopic MRI.
- Lee JH, Badar F, Kahn D, Matyas J, Qu X, Chen CT, Xia Y Connect. Tissue Res. 2014 Feb
- Failed healing of rotator cuff repair correlates with altered collagenase and gelatinase in supraspinatus and subscapularis tendons.
- Robertson CM, Chen CT, Shindle MK, Cordasco FA, Rodeo SA, Warren RF Am J Sports Med 2012 Sep 40 9 1993-2001
- Full-thickness supraspinatus tears are associated with more synovial inflammation and tissue degeneration than partial-thickness tears.
- Shindle MK, Chen CC, Robertson C, DiTullio AE, Paulus MC, Clinton CM, Cordasco FA, Rodeo SA, Warren RF J Shoulder Elbow Surg 2011 Sep 20 6 917-27
- Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage.
- Torzilli PA, Bhargava M, Park S, Chen CT Osteoarthr. Cartil. 2010 Jan 18 1 97-105
- Time, stress, and location dependent chondrocyte death and collagen damage in cyclically loaded articular cartilage.
- Chen CT, Bhargava M, Lin PM, Torzilli PA J. Orthop. Res. 2003 Sep 21 5 888-98
- Acceleration of cartilage repair by genetically modified chondrocytes over expressing bone morphogenetic protein-7.
- Hidaka C, Goodrich LR, Chen CT, Warren RF, Crystal RG, Nixon AJ J. Orthop. Res. 2003 Jul 21 4 573-83
- Matrix fixed-charge density as determined by magnetic resonance microscopy of bioreactor-derived hyaline cartilage correlates with biochemical and biomechanical properties.
- Chen CT, Fishbein KW, Torzilli PA, Hilger A, Spencer RG, Horton WE Arthritis Rheum. 2003 Apr 48 4 1047-56
- Chondrocyte necrosis and apoptosis in impact damaged articular cartilage.
- Chen CT, Burton-Wurster N, Borden C, Hueffer K, Bloom SE, Lust G J. Orthop. Res. 2001 Jul 19 4 703-11
- Compositional and metabolic changes in damaged cartilage are peak-stress, stress-rate, and loading-duration dependent.
- Chen CT, Burton-Wurster N, Lust G, Bank RA, Tekoppele JM J. Orthop. Res. 1999 Nov 17 6 870-9
Tissue Explant Models. In Post-traumatic lArthritis: Pathogensis, Diagnosis, and Management
Chan, CT and Torzilli, PA (2015). New York, Springer Science
Musculoskeletal Effects of Obesity. In Current Opinion in Pediatric Orthopedics
Chan G and Chen CT (2009). Lippincott Williams & Wilkins
Honors & Awards
- Eastern Orthopaedic Society Founder’s Award
- Fellow of National Arthritis Research Foundation
National Arthritis Research Foundation (2004)
- Herodicus Award, Herodicus Society
American Orthopaedic Society for Sports Medicine (2003)
- MSRC Biomechanics Award in Bone/Orthopedics
American Society of Biomechanics (1999)
- American Society for Bone and Mineral Research (2013)
- International Chinese Musculoskeletal Research Society (2007)
- Osteoarthritis Research Society International (2006)
- Orthopaedic Research Society (2000)
- American Society of Biomechanics (1996)
- American Society of Mechanical Engineers (1994)