Christopher Chen, Ph.D.

Assistant Professor

Department: Orthopaedic Surgery

Graduate Programs: Biomedical Engineering

Biography

Dr. Chen joined UT Southwestern in 2010 as an Assistant Professor and the Director of Research in the Department of Orthopedic Surgery. He is also the Director of Biomaterials, Mechanics, and Tissue Engineering Track of the Biomedical Engineering Program at UT Southwestern. Dr. Chen’s research is focused on early changes of injured joints and the role of mechanobiology in joint inflammation and cartilage degeneration. He is also working on connective tissue repair/regeneration (bone, ligament, tendon and cartilage). His studies are supported by National Institutes of Health and multiple foundations (Arthritis Foundation, ANRF AOSSM, OTA, AANA and OREF). Dr. Chen has contributed to more than 30 peer-review papers in the field of orthopedics and bioengineering.

Education

Undergraduate National Taiwan University - Taiwan (1986)
Graduate School University of Wisconsin-Madison (1991), Mechanical Engineering
Graduate School University of Wisconsin-Madison (1996)

Research Interests

  • Connective Tissue Healing (bone, ligament, tendon, and cartilage)
  • Connective Tissue Imaging (MRI, CT, FTIR, Ultrasound)
  • Posttraumatic Arthritis and Cartilage Degeneration
  • Tissue Engineering and Cartilage Mechanobiology
  • Tissue Mechanics

Publications

Featured Publications Legend

Featured Publications

A Comparative Study of Fibronectin Cleavage by MMP-1, -3, -13, and -14

X Zhang, Chen CT, Bhargava M, Torzilli PA Cartilage 2012 3 3 267-277

Full-thickness supraspinatus tears are associated with more synovial inflammation and tissue degeneration than partial-thickness tears (*Corresponding Author)

MK Shindle, CT Chen, C Robertson, AE DiTullio, MC Paulus, CM Clinton, FA Cordasco, SA Rodeo, RF. Warren J Shoulder & Elbow Surgery 2011 20 6

Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage

Torzilli PA, Bhargava M, Park S, Chen C.T. Osteoarthritis and Cartilage January 2010 18(1) 97-105

Chondrocyte death and cartilage degradation after autologous osteochondral transplantation surgery in a rabbit model

Gulotta LV, Rudzki JR, Kovacevic D, Chen CC, Milentijevic D, Williams RJ 3rd. Am J Sports Med July 2009 37(7) 1324-33

Material properties of fresh cold-stored allografts for osteochondral defects at 1 year

Ranawat AS, Vidal AF, Chen CT, Zelken JA, Turner AS, Williams RJ 3rd. Clinical Orthopaedics and Related Research August 2008 466(8) 1826-36

Biochemical and biomechanical properties of lesion and peri-lesion tissue after cartilage repair with genetically modified chondrocytes in an equine model.

Strauss E., Hidaka C., Chen CT, Goodrich L., Nixon A Am. J. Sport Medicine 2006 33 1647-53

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Honors/Awards

  • Eastern Orthopaedic Society Founder’s Award
    (2007)
  • Fellow of National Arthritis Research Foundation
    National Arthritis Research Foundation (2004)
  • Herodicus Award, Herodicus Society
    American Orthopaedic Society for Sports Medicine (2003)
  • MSRC Biomechanics Award in Bone/Orthopedics
    American Society of Biomechanics (1999)

Professional Associations/Affiliations

  • American Society of Biomechanics
  • American Society of Mechanical Engineers
  • Orthopaedic Research Society
  • Osteoarthritis Research Society International