David Corey, Ph.D.

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Dr. David R. Corey was born in Cambridge. Mass., August 13, 1963. He received his BA degree in Chemistry from Harvard University in 1985, and his PhD in Chemistry from the University of California at Berkeley in 1990. He completed postdoctoral training with Dr. Charles Craik in the Department of Pharmaceutical Chemistry at the University of California at San Francisco (1990-1992). In 1992 Dr. Corey joined the faculty of the Department of Pharmacology at the University of Texas Southwestern Medical Center at Dallas as an Assistant Professor. In 1996 Dr. Corey recieved a secondary appointment to the Department of Biochemistry, and in 1998 he was promoted to Associate Professor and to Full Professor in 2003.

Undergraduate	Harvard University (), Chemistry
Graduate School	University of California-berkeley (1990)

• antigene oligonucleotides
• antisense oligonucleotides
• Nucleic acids
• RNAi
• Telomerase

Featured Publications

Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.

Yu D, Pendergraff H, Liu J, Kordasiewicz HB, Cleveland DW, Swayze EE, Lima WF, Crooke ST, Prakash TP, Corey DR Cell 2012 Aug 150 5 895-908

Expanding the action of duplex RNAs into the nucleus: redirecting alternative splicing.

Liu J, Hu J, Corey DR Nucleic Acids Res. 2012 Feb 40 3 1240-50

Regulation of transcription by small RNAs complementary to sequences downstream from the 3? termini of genes.

Yue, X., Schwartz, J. C., Younger, S. T., Chu, Y., Gagnon, K.T., Elbashir, S., Janowski, B. A., Corey, D. R. Nature Chemical Biology Summer 2010 6 621-629

Inhibition of mutant huntingtin expression by targeting mutant RNA structure.

Hu, J., Matsui, M., Gagnon, K. T., Schwartz, J. C., Gabillet, S., Arar, K., Wu, J., Bezprozvanny, I., and Corey, D. R. Nature Biotechnology Summer 2009 27 478-484

Antisense transcripts are targets for small activating RNAs

Schwartz, J. C., Younger, S. T., Nguyen, N-B., Hardy, D. B., Corey, D. R., and Janowski, B. A. Nature Structural and Molecular Biology 2008 8/15 842-849

Inhibiting transcription of chromosomal DNA using antigene peptide nucleic acids.

Janowski, B. A., Kaihatsu, K., Huffman, K. E., Schwartz, J. C., Ram, R., Hardy, D., Mendelson, C. R., and Corey D. R. Nature Chemical Biology Summer 2005 1 210-215

Transcriptional silencing by single-stranded RNAs targeting a noncoding RNA that overlaps a gene promoter.

Matsui M, Prakash TP, Corey DR ACS Chem. Biol. 2013 Jan 8 1 122-6

Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathway.

Hu J, Liu J, Yu D, Chu Y, Corey DR Nucleic Acids Res. 2012 Dec 40 22 11270-80

Transcriptional silencing by hairpin RNAs complementary to a gene promoter.

Chu Y, Kalantari R, Dodd DW, Corey DR Nucleic Acid Ther 2012 Jun 22 3 147-51

Allele-selective inhibition of trinucleotide repeat genes.

Matsui M, Corey DR Drug Discov. Today 2012 May 17 9-10 443-50

• Excellence Postdoctoral Mentoring Award
  (2010)
• McKnight Neuroscience Award
  (2009)
• Welch Lectueship
  (2003)
• CaP Cure Research Award
  (1996)
• Damon Runyon Postdoctoral Fellowship
  (1990)

• American Cancer Society
• American Chemical Society
• American Society of Pharmacology & Experimental Therapeutics