Melanie Cobb received her undergraduate degree in biochemistry from the University of Chicago and her PhD in biological chemistry from Washington University in St. Louis in the laboratory of Garland Marshall. Following postdoctoral work with Ora Rosen at the Albert Einstein College of Medicine in New York, she joined the Department of Pharmacology at UT Southwestern Medical Center in Dallas where she is currently a Professor and the holder of the Jane and Bill Browning, Jr Chair in Medical Science. Her interests are in cellular regulatory mechanisms.


Graduate School
Washington University (1976)

Research Interest

  • cancer biology
  • protein kinase structure/function
  • regulation of nutrient responses
  • signal transduction mechanisms
  • vesicular trafficking


Featured Publications LegendFeatured Publications

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.
Augustyn A, Borromeo M, Wang T, Fujimoto J, Shao C, Dospoy PD, Lee V, Tan C, Sullivan JP, Larsen JE, Girard L, Behrens C, Wistuba II, Xie Y, Cobb MH, Gazdar AF, Johnson JE, Minna JD Proc. Natl. Acad. Sci. U.S.A. 2014 Sep
Ras transformation uncouples the kinesin-coordinated cellular nutrient response.
Zaganjor E, Weil LM, Gonzales JX, Minna JD, Cobb MH Proc. Natl. Acad. Sci. U.S.A. 2014 Jul 111 29 10568-73