W. Lee Kraus, PhD, is the Director of the Cecil H. and Ida Green Center for Reproductive Biology Sciences. He is also Professor and Vice Chair for Basic Sciences in the Department of Obstetrics and Gynecology, and a Professor in the Department of Pharmacology. Dr. Kraus also holds the Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences.
Dr. Kraus did his graduate research on the regulation of steroid hormone receptor activity in the laboratory of Dr. Benita S. Katzenellenbogen at the University of Illinois, Urbana-Champaign and received his PhD in 1994.
He did his postdoctoral research on the mechanisms of transcriptional regulation with chromatin in the laboratory of Dr. Jim Kadonaga at the University of California, San Diego. During his postdoctoral work, Dr. Kraus was supported by fellowships from the National Institutes of Health and the American Cancer Society, California Division.
Prior to joining the faculty at UT Southwestern, Dr. Kraus was a professor in the Department of Molecular Biology and Genetics at Cornell University in Ithaca. He also held a joint appointment in the Department of Pharmacology at the Weill Medical College of Cornell University in New York City.
Dr. Kraus has been supported by a Career Award in the Biomedical Sciences/Reproductive Biology from the Burroughs Wellcome Fund, as well as grants from the National Institutes of Health, the American Cancer Society, the Endocrine Society, and the National Science Foundation.
- Cornell University (1989), Animal Science
- Graduate School
- Univ of Illinois @ Urbana-Cham (1991), Physiology
- Graduate School
- Univ of Illinois @ Urbana-Cham (1994), Physiology
- Cancer biology (esp. breast cancer)
- Chromatin structure and gene regulation
- Computational genomics
- Hormonal signaling
- Molecular physiology of reproduction, inflammation, and adipogenesis
- SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation.
- Doiguchi M, Nakagawa T, Imamura Y, Yoneda M, Higashi M, Kubota K, Yamashita S, Asahara H, Iida M, Fujii S, Ikura T, Liu Z, Nandu T, Kraus WL, Ueda H, Ito T Sci Rep 2016 6 20179
- Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation
- Gibson, B.A., Zhang, Y., Jiang, H., Hussey, K.M., Shrimp, J.H., Lin, H., Schwede, F., Yu, Y., and Kraus, W.L. Science 2016 353 45-50
- Editorial: Would You Like A Hypothesis With Those Data? Omics and the Age of Discovery Science.
- Kraus WL Mol. Endocrinol. 2015 Nov 29 11 1531-4
- No Driver behind the Wheel? Targeting Transcription in Cancer.
- Franco HL, Kraus WL Cell 2015 Sep 163 1 28-30
- Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways.
- Liu X, Kraus WL, Bai X Trends Biochem. Sci. 2015 Sep 40 9 516-25
- Discovery, Annotation, and Functional Analysis of Long Noncoding RNAs Controlling Cell-Cycle Gene Expression and Proliferation in Breast Cancer Cells.
- Sun M, Gadad SS, Kim DS, Kraus WL Mol. Cell 2015 Aug 59 4 698-711
- PARPs and ADP-Ribosylation Come Into Focus.
- Kraus WL Mol. Cell 2015 Jun 58 6 901
- Identification of active transcriptional regulatory elements from GRO-seq data.
- Danko CG, Hyland SL, Core LJ, Martins AL, Waters CT, Lee HW, Cheung VG, Kraus WL, Lis JT, Siepel A Nat. Methods 2015 Mar
- TNFa Signaling Exposes Latent Estrogen Receptor Binding Sites to Alter the Breast Cancer Cell Transcriptome.
- Franco HL, Nagari A, Kraus WL Mol. Cell 2015 Mar
- groHMM: a computational tool for identifying unannotated and cell type-specific transcription units from global run-on sequencing data.
- Chae M, Danko CG, Kraus WL BMC Bioinformatics 2015 16 222
Honors & Awards
- Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences
- Cornell University College of Agriculture and Life Sciences Excellence in Mentoring Undergraduate Students in Independent Research Award
- Richard E. Weitzman Memorial Award from the Endocrine Society
- Distinguished Alumni Award from the Department of Molecular and Integrative Physiology, University of Illinois, Urbana-Champaign
- Cornell University College of Agriculture and Life Sciences Young Faculty Teaching Excellence Award
- Burroughs Wellcome Fund Career Award in the Biomedical Sciences, Reproductive Biology