David Chuang, Ph.D.

Professor

Department: Biochemistry, Internal Medicine

Graduate Programs: Biological Chemistry

Education

Graduate School National Taiwan University - Taiwan (1964)
Graduate School Utah State University (1970)

Research Interests

  • Chaperone-mediated biogenesis of mitochondrial multi-enzyme complexes.
  • Molecular genetic and biochemical basis of maple syrup urine disease.
  • Structure and protein-protein interactions of mitochondrial multienzyme complexes.

Publications

Featured Publications Legend

Featured Publications

Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of the human pyruvate dehydrogenase complex.

Kato, M., Chuang, J.L., Tso, S.-C., Wynn, R.M., and Chuang, D.T. EMBO J. 2005 24 1763-1774

Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations.

Brautigam, C. A., Chuang, J. L., Tomchick, D. R., Machius, M. and Chuang, D. T. J. Mol. Biol. 2005 350 543-552

Molecular mechanism for regulation of the human mitochondrial branched-chain a-ketoacid dehydrogenase complex by phosphorylation.

Wynn, R.M., Kato, M., Machius, M., Chuang J.L., Li J, Tomchick D.R., and Chuang, D.T. Structure 2004 12 2185-2196

Seeing GroEL at 6 ? resolution by single particle electron cryomicroscopy.

Ludtke, S., Chen, D., Song, J.-L., Chuang, D.T., and Chiu, W. Structure 2004 12 1129-1136

Crosstalk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain a-ketoacid decarboxylase/dehydrogenase.

Li, J., Wynn, R. M., Machius, M., Chuang, J. L., Karthikeyan, S., Tomchick, D. R., and Chuang, D. T. J. Biol. Chem. 2004 279 32968-32978

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Honors/Awards

  • VA Administration Central Ofc-Washington DC
    Associate Career Scientist Award (1988)
  • VA Medical Center-Cleveland OH
    Outstanding Performance Awards (1987)
  • VA Medical Center-Cleveland OH
    Outstanding Performance Awards (1986)
  • VA Medical Center-Cleveland OH
    Outstanding Performance Awards (1985)

Professional Associations/Affiliations

  • American Association for the Advancement of Science
  • American Society for Biochemistry and Molecular Biology
  • American Society for Human Genetics
  • Society of Chinese Bioscientists in America